COMMENTARY Multivitamin Supplements, Ageing, and Loss of Vision Seeing Through the Shadows N THE FEBRUARY 23, 2009, (NNT, 167). Overall study medica- WHY ARE THE FINDINGS issue of the Archives, Chris- tion adherence was 84% for both the FROM WAFACS IMPORTANT? ten et al reported the re- intervention and placebo groups, sults of a large clinical trial and the treatment was well toler- Considering that there are cur- I evaluating the effects of a ated, with an adverse effects profile rently no recognized means to pre- combination of folic acid, pyridox- similar to placebo. In a subsample vent the early stages of the develop- ine hydrochloride (vitamin B ), and 6 of 300 participants who completed ment of AMD other than avoidance cyanocobalamin (vitamin B ) on the 12 the study, there were no significant of cigarette smoking, these obser- development of age-related macu- baseline differences in median vations may indeed have consider- lar degeneration (AMD). This re- plasma folate (8.8 ng/mL vs 8.9 able public health implications. In port, the Women’s Antioxidant and ng/mL [to convert to nanomoles per 1996, the US Food and Drug Ad- Folic Acid Cardiovascular Study liter, multiply by 2.266] [P=.94]) or ministration (FDA)
JAMA Internal Medicine – American Medical Association
Published: Jul 13, 2009
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