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Multiplicities in the Assessment of Multiple Vitamins

Multiplicities in the Assessment of Multiple Vitamins Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Multiplicities in the Assessment of Multiple Vitamins Is It Too Soon to Tell Men That Vitamins Prevent Cancer? clude multiple substances. The multivitamin used in the in- Peter B. Bach, MD, MAPP tervention group of the PHS II study contained 30 different Roger J. Lewis, MD, PhD vitamins and minerals in a single pill. It is plausible that some components of the multivitamin matter, whereas other com- N THIS ISSUE OF JAMA,GAZIANO AND COLLEAGUES RE- ponents probably can be ignored. However, knowing which port one of several analyses of data from the Physicians’ components fall into each category is important in under- Health Study II (PHS II) randomized controlled trial. standing the biological plausibility of any potential mecha- IAmong more than 14 000 male physicians who partici- nism for cancer prevention. This point is emphasized by sev- pated in this study, the authors report a marginally statisti- eral studies that have shown that some mineral and vitamin cally significant (P=.04) inverse relationship between taking supplements are harmful and cause cancer. For instance, caro- a daily multivitamin (Centrum Silver) and the occurrence http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Multiplicities in the Assessment of Multiple Vitamins

JAMA , Volume 308 (18) – Nov 14, 2012

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2012.53273
pmid
23150011
Publisher site
See Article on Publisher Site

Abstract

Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Multiplicities in the Assessment of Multiple Vitamins Is It Too Soon to Tell Men That Vitamins Prevent Cancer? clude multiple substances. The multivitamin used in the in- Peter B. Bach, MD, MAPP tervention group of the PHS II study contained 30 different Roger J. Lewis, MD, PhD vitamins and minerals in a single pill. It is plausible that some components of the multivitamin matter, whereas other com- N THIS ISSUE OF JAMA,GAZIANO AND COLLEAGUES RE- ponents probably can be ignored. However, knowing which port one of several analyses of data from the Physicians’ components fall into each category is important in under- Health Study II (PHS II) randomized controlled trial. standing the biological plausibility of any potential mecha- IAmong more than 14 000 male physicians who partici- nism for cancer prevention. This point is emphasized by sev- pated in this study, the authors report a marginally statisti- eral studies that have shown that some mineral and vitamin cally significant (P=.04) inverse relationship between taking supplements are harmful and cause cancer. For instance, caro- a daily multivitamin (Centrum Silver) and the occurrence

Journal

JAMAAmerican Medical Association

Published: Nov 14, 2012

References