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MULTIPLE SCLEROSIS WITH LATE ONSET OF SYMPTOMS

MULTIPLE SCLEROSIS WITH LATE ONSET OF SYMPTOMS Abstract The onset of symptoms in multiple sclerosis usually occurs between the second and the fourth decade of life. Its diagnosis, with few exceptions, is rarely entertained when signs of involvement of the central nervous system make their appearance in the fifth or the sixth decade of life. Wilson,1 in a series of 1,107 cases of multiple sclerosis, found onset of symptoms after the age of 40 in 186, or 17 per cent, while von Hoesslin2 found onset after the age of 50 in only 4 per cent. In many of the aforementioned cases the diagnosis was not verified by autopsy. Isolated examples of a very late onset with autopsy include Nielsen's3 case, in which illness began in the late sixties, and Taga's4 cases, in which the disease began after the age of 60. In a series of 310 patients with multiple sclerosis who had been admitted References 1. Wilson, S. A. K.: Neurology , edited by A. N. Bruce, Baltimore, Williams & Wilkins Company, 1940. 2. von Hoesslin, R.: Ueber multiple Sklerose: Exogene Aetiologie, Pathogenese und Verlauf , Munich, J. F. Lehmann, 1934. 3. Nielsen, J. M.: A Textbook of Clinical Neurology , New York, Paul B. Hoeber, Inc., 1940. 4. Taga, K.: Zur Kenntnis der senilen multiplen Sklerose , Arb. a. d. neurol. Inst. a d. Wien. Univ. 31: 163, 1929. 5. Davison, C.; Goodhart, S. P., and Lander, J.: Multiple Sclerosis and Amyotrophies , Arch. Neurol. & Psychiat. 31:270 ( (Feb.) ) 1934. 6. The exclusive incidence of Jewish patients in this series is due to the fact that the patients admitted to the Montefiore Hospital are predominantly Jewish. 7. Birley, J. L., and Dudgeon, L. S.: Clinical and Experimental Contribution to Pathogenesis of Disseminated Sclerosis , Brain 44:150, 1921. 8. Putnam, T. J.: Multiple Sclerosis and "Encephalomyelitis," Bull.New York Acad. Med. 19:301, 1943. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

MULTIPLE SCLEROSIS WITH LATE ONSET OF SYMPTOMS

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Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1945.02300110032005
Publisher site
See Article on Publisher Site

Abstract

Abstract The onset of symptoms in multiple sclerosis usually occurs between the second and the fourth decade of life. Its diagnosis, with few exceptions, is rarely entertained when signs of involvement of the central nervous system make their appearance in the fifth or the sixth decade of life. Wilson,1 in a series of 1,107 cases of multiple sclerosis, found onset of symptoms after the age of 40 in 186, or 17 per cent, while von Hoesslin2 found onset after the age of 50 in only 4 per cent. In many of the aforementioned cases the diagnosis was not verified by autopsy. Isolated examples of a very late onset with autopsy include Nielsen's3 case, in which illness began in the late sixties, and Taga's4 cases, in which the disease began after the age of 60. In a series of 310 patients with multiple sclerosis who had been admitted References 1. Wilson, S. A. K.: Neurology , edited by A. N. Bruce, Baltimore, Williams & Wilkins Company, 1940. 2. von Hoesslin, R.: Ueber multiple Sklerose: Exogene Aetiologie, Pathogenese und Verlauf , Munich, J. F. Lehmann, 1934. 3. Nielsen, J. M.: A Textbook of Clinical Neurology , New York, Paul B. Hoeber, Inc., 1940. 4. Taga, K.: Zur Kenntnis der senilen multiplen Sklerose , Arb. a. d. neurol. Inst. a d. Wien. Univ. 31: 163, 1929. 5. Davison, C.; Goodhart, S. P., and Lander, J.: Multiple Sclerosis and Amyotrophies , Arch. Neurol. & Psychiat. 31:270 ( (Feb.) ) 1934. 6. The exclusive incidence of Jewish patients in this series is due to the fact that the patients admitted to the Montefiore Hospital are predominantly Jewish. 7. Birley, J. L., and Dudgeon, L. S.: Clinical and Experimental Contribution to Pathogenesis of Disseminated Sclerosis , Brain 44:150, 1921. 8. Putnam, T. J.: Multiple Sclerosis and "Encephalomyelitis," Bull.New York Acad. Med. 19:301, 1943.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Nov 1, 1945

References