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Multiple Pathologic Pathways to Dementia in Football Players With Chronic Traumatic Encephalopathy

Multiple Pathologic Pathways to Dementia in Football Players With Chronic Traumatic Encephalopathy Opinion EDITORIAL Multiple Pathologic Pathways to Dementia in Football Players With Chronic Traumatic Encephalopathy Julie A. Schneider, MD, MS The neuropathologic basis of dementia in aging is a complex arteriolosclerosis were quite common, with each being pres- tapestry of misfolded proteins, vascular changes, and neuro- ent in almost half of the cases. Meanwhile, about one-fourth of the cases had 1 or more microinfarcts, whereas larger infarcts degeneration that converge on the brains of persons with dis- tinct genetic and ecologic backgrounds. Within this framework, and microbleeds were less common. The authors used simul- it is perhaps unsurprising that taneous equations regression modeling (a form of structural neuropathologic understand- equation modeling) to investigate the potential neuropatho- Related article page 1298 ing of dementia in aging indi- logic pathways, with the number of years of play as the inde- viduals who played US football continues to evolve in com- pendent variable and dementia as the outcome after control- plexity. Repetitive head impacts have been linked to chronic ling for age and race. The authors have previously shown years traumatic encephalopathy (CTE), a brain pathology later de- of play to be associated with CTE, and they used this as a proxy fined http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Multiple Pathologic Pathways to Dementia in Football Players With Chronic Traumatic Encephalopathy

JAMA Neurology , Volume 76 (11) – Nov 5, 2019

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Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2019.1089
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Multiple Pathologic Pathways to Dementia in Football Players With Chronic Traumatic Encephalopathy Julie A. Schneider, MD, MS The neuropathologic basis of dementia in aging is a complex arteriolosclerosis were quite common, with each being pres- tapestry of misfolded proteins, vascular changes, and neuro- ent in almost half of the cases. Meanwhile, about one-fourth of the cases had 1 or more microinfarcts, whereas larger infarcts degeneration that converge on the brains of persons with dis- tinct genetic and ecologic backgrounds. Within this framework, and microbleeds were less common. The authors used simul- it is perhaps unsurprising that taneous equations regression modeling (a form of structural neuropathologic understand- equation modeling) to investigate the potential neuropatho- Related article page 1298 ing of dementia in aging indi- logic pathways, with the number of years of play as the inde- viduals who played US football continues to evolve in com- pendent variable and dementia as the outcome after control- plexity. Repetitive head impacts have been linked to chronic ling for age and race. The authors have previously shown years traumatic encephalopathy (CTE), a brain pathology later de- of play to be associated with CTE, and they used this as a proxy fined

Journal

JAMA NeurologyAmerican Medical Association

Published: Nov 5, 2019

References