Abstract REPORT OF A CASE A 12-year-old Indian girl, from Puerto Inírida in the comissary of Guainía in the Colombian Orinochian jungle in South America, presented for evaluation of asymptomatic oral lesions of approximately 1 year's duration; the lesions were initially noted on the mucosa of the lips, but they progressively extended to other areas of the oral mucosa. The girl was otherwise in good health, and her medical history was essentially normal. According to her relatives, many members of their tribe, especially children, had similar ailments, some with lesions even more prominent.Findings from the physical examination revealed numerous irregularly distributed, sharply circumscribed, rounded or ovoid firm papules with a slightly corrugated surface. These lesions were 1 to 5 mm in diameter (Fig 1) and were located on the mucosa of lips, cheeks, tongue, and hard palate. The color of most of the lesions was similar to that of the References 1. Archard HO, Heck JW, Stanley HR. Focal epithelial hyperplasia: an unusual oral mucosa lesion found in Indian children . Oral Surg Oral Med Oral Pathol. 1965;20;201-212.Crossref 2. Pindborg JJ. Atlas de enfermedades de la mucosa oral . 4th ed. Barcelona, Spain: Salvat Editores SA; 1986:200. 3. Witkop CJ, Niswander JD. Focal epithelial hyperplasia in Central and South American Indians and Latinos . Oral Surg Oral Med Oral Pathol. 1965;20:213-217.Crossref 4. Galindo W, Niño de Guzman M. Focal epithelial hyperplasia: report of four cases in Mestizos from Cochabamba, Bolivia . Oral Surg Oral Med Oral Pathol. 1969;27:15-19.Crossref 5. Fischman SL. Focal epithelial hyperplasia: case reports from Paraguay and Peru . Oral Surg Oral Med Oral Pathol. 1969;28:389-393.Crossref 6. Gómez A, Calle C, Pindborg JJ. Focal epithelial hyperplasia in a half-breed family of Colombians . J Am Dermatol Assoc. 1969; 79:663-667. 7. Schock RK. Familial focal epithelial hyperplasia . Oral Surg Oral Med Oral Pathol. 1969;28:598-602.Crossref 8. Tan KN, Medak H, Cohen L. Focal epithelial hyperplasia in a Mexican Indian . Arch Dermatol. 1969;100:474-477.Crossref 9. Perriman A, Uthman A. Focal epithelial hyperplasia: report of seven cases from Iraq . Oral Surg. 1971;31:221-225.Crossref 10. Buchner A, Ramon Y. Focal epithelial hyperplasia: report of two cases from Israel and review of the literature . Arch Dermatol. 1973;107:97-98.Crossref 11. Buchner A, Mass E. Focal epithelial hyperplasia in an Israeli family . Oral Surg. 1973;36:507-511.Crossref 12. Starnik TM, Woerdeman MJ. Focal epithelial hyperplasia of the oral mucosa: report of two cases from the Netherlands and review of the literature . Br J Dermatol. 1977;96:375-380.Crossref 13. Van Wyk CW. Focal epithelial hyperplasia of the mouth: recently discovered in South Africa . Br J Dermatol 1977;96:381-388.Crossref 14. Stiefler RE, Solomon MP. Heck's disease (focal epithelial hyperplasia) . J Am Acad Dermatol. 1979;1:499-502.Crossref 15. Hanks CT, Fischman SL, Niño de Guzman M. Focal epithelial hyperplasia: a light and electron microscopic study of one case . Oral Surg. 1972;33:934-943.Crossref 16. Pfister H, Hettich I, Runne V, Gissman L, Chief GN. Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions . J Virol. 1983;47:363-366.
Archives of Dermatology – American Medical Association
Published: Jun 1, 1991