Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Multiple Evanescent White Dot Syndrome: II. Electrophysiology of the Photoreceptors During Retinal Pigment Epithelial Disease

Multiple Evanescent White Dot Syndrome: II. Electrophysiology of the Photoreceptors During... Abstract • We performed electrophysiologic studies of photoreceptor function in three patients with multiple evanescent white dot syndrome. During the acute stage, while the visual acuity was impaired, the electroretinogram (ERG) a-wave and the early receptor potential (ERP) amplitudes were profoundly decreased. The ERP regeneration times, determined for one subject, were prolonged. These findings suggest that photoreceptor function was impaired (abnormal a-wave), the effective visual pigment optical density of the outer segments was markedly reduced (ERP amplitude), and visual pigment regeneration was abnormal (ERP regeneration kinetics). During the recovery stage, the ERG and ERP amplitudes and visual acuity returned to normal. Our patients' disease seemed to be primarily of the retinal pigment epithelium (RPE). The decreased visual pigment density and prolonged regeneration kinetics emphasize the physiologic dependence of the sensory retina on the RPE. References 1. Brown K, Watanabe K, Murakami M: The early and late receptor potentials of monkey cones and rods . Cold Spring Harbor Symp Quant Biol 1965;30:457-482.Crossref 2. Cone RA, Brown PK: Dependence of the early receptor potential on the orientation of rhodopsin . Science 1967;156:536. 3. Jampol LM, Sieving PA, Pugh D, et al: Multiple evanescent white dot syndrome: I. Clinical findings . Arch Ophthalmol , 1984;102:671-674.Crossref 4. Smith VC, Pokorny J, Ernest JTE, et al: Visual function in acute posterior multifocal placoid pigment epitheliopathy . Am J Ophthalmol 1978;85:192-199. 5. Hansen RM, Fulton AB: Cone pigments in acute posterior multifocal placoid pigment epitheliopathy . Am J Ophthalmol 1981;91:465-468. 6. Gass JDM: Acute posterior multifocal placoid pigment epitheliopathy . Arch Ophthalmol 1968;80:177-185.Crossref 7. Alpern M, Maaseidvaag F, Ohba N: The kinetics of cone visual pigments in man . Vision Res 1971;11:539-549.Crossref 8. Sieving PA: In vivo determination of visual pigment regeneration in humans by measurements of the early receptor potential (ERP), thesis. University of Illinois Medical Center, Chicago, 1981. 9. Sieving PA, Fishman GA, Alexander KR, et al: Early receptor potential (ERP) recordings in human ocular siderosis . Arch Ophthalmol 1983;101:1716-1720.Crossref 10. Osterberg G: Topography of the layers of rods and cones in the human retina . Acta Ophthalmol 1935;13( (suppl 6) ):11-102. 11. Sieving PA, Fishman GA: Rod contribution to the human early receptor potential (ERP) estimated from monochromats' data . Doc Ophthalmol Proc Series 1982;31:95-102. 12. Krill AE, Deutman AF: Acute retinal pigment epitheliitus . Am J Ophthalmol 1972;74:193-205. 13. Fishman GA, Rabb MF, Kaplan J: Acute posterior multifocal placoid pigment epitheliopathy . Arch Ophthalmol 1974;92:173-177.Crossref 14. Ryan SJ, Maumenee AE: Birdshot retinochoroidopathy . Am J Ophthalmol 1980;89:31-45. 15. Pak WL: Some properties of the early electrical response in the vertebrate retina . Cold Spring Harbor Symp Quant Biol 1965;30:493-499.Crossref 16. Brindley GS, Gardner-Medwin AR: The origin of the early receptor potential of the retina . J Physiol 1966;182:185-194. 17. Smith VC, Pokorny J, Diddie KR: Color matching and Stiles-Crawford effect in central serous choroidopathy . Mod Probl Ophthalmol 1978;19:284-295. 18. Weinstein GW, Hobson RR, Dowling JE: Light and dark adaptation in the isolated rat retina . Nature 1967;215:134-138.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Multiple Evanescent White Dot Syndrome: II. Electrophysiology of the Photoreceptors During Retinal Pigment Epithelial Disease

Loading next page...
 
/lp/american-medical-association/multiple-evanescent-white-dot-syndrome-ii-electrophysiology-of-the-eJqCfd9HEp
Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030531009
Publisher site
See Article on Publisher Site

Abstract

Abstract • We performed electrophysiologic studies of photoreceptor function in three patients with multiple evanescent white dot syndrome. During the acute stage, while the visual acuity was impaired, the electroretinogram (ERG) a-wave and the early receptor potential (ERP) amplitudes were profoundly decreased. The ERP regeneration times, determined for one subject, were prolonged. These findings suggest that photoreceptor function was impaired (abnormal a-wave), the effective visual pigment optical density of the outer segments was markedly reduced (ERP amplitude), and visual pigment regeneration was abnormal (ERP regeneration kinetics). During the recovery stage, the ERG and ERP amplitudes and visual acuity returned to normal. Our patients' disease seemed to be primarily of the retinal pigment epithelium (RPE). The decreased visual pigment density and prolonged regeneration kinetics emphasize the physiologic dependence of the sensory retina on the RPE. References 1. Brown K, Watanabe K, Murakami M: The early and late receptor potentials of monkey cones and rods . Cold Spring Harbor Symp Quant Biol 1965;30:457-482.Crossref 2. Cone RA, Brown PK: Dependence of the early receptor potential on the orientation of rhodopsin . Science 1967;156:536. 3. Jampol LM, Sieving PA, Pugh D, et al: Multiple evanescent white dot syndrome: I. Clinical findings . Arch Ophthalmol , 1984;102:671-674.Crossref 4. Smith VC, Pokorny J, Ernest JTE, et al: Visual function in acute posterior multifocal placoid pigment epitheliopathy . Am J Ophthalmol 1978;85:192-199. 5. Hansen RM, Fulton AB: Cone pigments in acute posterior multifocal placoid pigment epitheliopathy . Am J Ophthalmol 1981;91:465-468. 6. Gass JDM: Acute posterior multifocal placoid pigment epitheliopathy . Arch Ophthalmol 1968;80:177-185.Crossref 7. Alpern M, Maaseidvaag F, Ohba N: The kinetics of cone visual pigments in man . Vision Res 1971;11:539-549.Crossref 8. Sieving PA: In vivo determination of visual pigment regeneration in humans by measurements of the early receptor potential (ERP), thesis. University of Illinois Medical Center, Chicago, 1981. 9. Sieving PA, Fishman GA, Alexander KR, et al: Early receptor potential (ERP) recordings in human ocular siderosis . Arch Ophthalmol 1983;101:1716-1720.Crossref 10. Osterberg G: Topography of the layers of rods and cones in the human retina . Acta Ophthalmol 1935;13( (suppl 6) ):11-102. 11. Sieving PA, Fishman GA: Rod contribution to the human early receptor potential (ERP) estimated from monochromats' data . Doc Ophthalmol Proc Series 1982;31:95-102. 12. Krill AE, Deutman AF: Acute retinal pigment epitheliitus . Am J Ophthalmol 1972;74:193-205. 13. Fishman GA, Rabb MF, Kaplan J: Acute posterior multifocal placoid pigment epitheliopathy . Arch Ophthalmol 1974;92:173-177.Crossref 14. Ryan SJ, Maumenee AE: Birdshot retinochoroidopathy . Am J Ophthalmol 1980;89:31-45. 15. Pak WL: Some properties of the early electrical response in the vertebrate retina . Cold Spring Harbor Symp Quant Biol 1965;30:493-499.Crossref 16. Brindley GS, Gardner-Medwin AR: The origin of the early receptor potential of the retina . J Physiol 1966;182:185-194. 17. Smith VC, Pokorny J, Diddie KR: Color matching and Stiles-Crawford effect in central serous choroidopathy . Mod Probl Ophthalmol 1978;19:284-295. 18. Weinstein GW, Hobson RR, Dowling JE: Light and dark adaptation in the isolated rat retina . Nature 1967;215:134-138.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1984

References