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L. Stutzman, E. Ezdinli, M. Stutzman (1966)
Vinblastine sulfate vs cyclophosphamide in the therapy for lymphoma.JAMA, 195 3
P. Carbone, C. Spurr, M. Schneiderman, J. Scotto, J. Holland, B. Shnider (1968)
Management of patients with malignant lymphoma: a comparative study with cyclophosphamide and vinca alkaloids.Cancer research, 28 5
A. Gellhorn, V. Collins (1951)
A quantitative evaluation of the contribution of nitrogen mustard to the therapeutic management of Hodgkin's disease.Annals of internal medicine, 35 6
L. Stutzman (1971)
Combined radiotherapy and chemotherapy of lymphomas and other cancers.Cancer research, 31 11
A. Aisenberg, J. Goldman (1971)
Prolongation of survival in Hodgkin's diseaseCancer, 27
J. Holland (1970)
Hopes for tomorrow versus realities of today: therapy and prognosis in acute lymphocytic leukemia of childhood.Pediatrics, 45 2
E. Ezdinli, L. Stutzman (1968)
Vinblastine VS. nitrogen mustard therapy of Hodgkin's diseaseCancer, 22
E. Ezdinli, L. Stutzman, C. Aungst, D. Firat (1969)
Corticosteroid therapy for lymphomas and chronic lymphocytic leukemiaCancer, 23
N. Breslow (1970)
A generalized Kruskal-Wallis test for comparing K samples subject to unequal patterns of censorshipBiometrika, 57
R. Deconti (1971)
Procarbazine in the management of late Hodgkin's disease.JAMA, 215 6
V. Devita, A. Serpick, P. Carbone (1970)
Combination chemotherapy in the treatment of advanced Hodgkin's disease.Annals of internal medicine, 73 6
E. Henderson, R. Samaha (1969)
Evidence That Drugs in Multiple Combinations Have Materially Advanced the Treatment of Human MalignanciesCancer Research, 29
A. Rapoport, P. Cole, J. Mason (1969)
Correlates of survival after initiation of chemotherapy in 142 cases of Hodgkin's diseaseCancer, 24
S. Lowenbraun, V. Devita, A. Serpick (1970)
Combination chemotherapy with nitrogen mustard, vincristine, procarbazine and prednisone in previously treated patients with Hodgkin's disease.Blood, 36 6
W. Nicholson, M. Beard, D. Crowther, A. Stansfeld, C. Vartan, J. Malpas, G. Fairley, R. Scott (1970)
Combination Chemotherapy in Generalized Hodgkin's DiseaseBritish Medical Journal, 3
R. Livingston, S. Carter (1970)
Single Agents in Cancer Chemotherapy
Two hundred forty-seven patients with disseminated Hodgkin disease were randomly treated with one of three intensive multiple-agent regimens. Partial or complete response rates of 90% were obtained with each routine. The "MOPP" regimen—mechlorethamine hydrochloride, vincristine sulfate (Oncovin), procarbazine hydrochloride, and prednisone—yielded the longest duration of response but also had the highest toxicity. There was no difference in survival rates among patients on the three routines. Major factors associated with good response were female sex and little or no prior therapy. Minor favorable factors were stage III disease, lack of systemic symptoms, former responsiveness to therapy, and age of less than 60 years. The simultaneous dosage routine was superior in both response rate and lessened toxicity compared to sequential usage of the same drugs with the same total dosage.
JAMA – American Medical Association
Published: Sep 3, 1973
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