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Multiple Chemotherapeutic Agents for Hodgkin Disease

Multiple Chemotherapeutic Agents for Hodgkin Disease Two hundred forty-seven patients with disseminated Hodgkin disease were randomly treated with one of three intensive multiple-agent regimens. Partial or complete response rates of 90% were obtained with each routine. The "MOPP" regimen—mechlorethamine hydrochloride, vincristine sulfate (Oncovin), procarbazine hydrochloride, and prednisone—yielded the longest duration of response but also had the highest toxicity. There was no difference in survival rates among patients on the three routines. Major factors associated with good response were female sex and little or no prior therapy. Minor favorable factors were stage III disease, lack of systemic symptoms, former responsiveness to therapy, and age of less than 60 years. The simultaneous dosage routine was superior in both response rate and lessened toxicity compared to sequential usage of the same drugs with the same total dosage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Multiple Chemotherapeutic Agents for Hodgkin Disease

JAMA , Volume 225 (10) – Sep 3, 1973

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1973.03220380026007
Publisher site
See Article on Publisher Site

Abstract

Two hundred forty-seven patients with disseminated Hodgkin disease were randomly treated with one of three intensive multiple-agent regimens. Partial or complete response rates of 90% were obtained with each routine. The "MOPP" regimen—mechlorethamine hydrochloride, vincristine sulfate (Oncovin), procarbazine hydrochloride, and prednisone—yielded the longest duration of response but also had the highest toxicity. There was no difference in survival rates among patients on the three routines. Major factors associated with good response were female sex and little or no prior therapy. Minor favorable factors were stage III disease, lack of systemic symptoms, former responsiveness to therapy, and age of less than 60 years. The simultaneous dosage routine was superior in both response rate and lessened toxicity compared to sequential usage of the same drugs with the same total dosage.

Journal

JAMAAmerican Medical Association

Published: Sep 3, 1973

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