Abstract THE PURPOSE OF this study is to report mucosal irritation in the newborn following prolonged use of gentian violet in the treatment of thrush. In addition, the irritative lesions secondary to application of gentian violet were reproduced experimentally. The use of 1% aqueous solution of gentian violet has been considered an accepted and safe treatment for oral thrush since its use was first reported in 1925 by Faber and Dickey.1 Standard pediatric and pharmacology textbooks fail to warn that prolonged topical application of gentian violet may cause local irritation. Gentian violet medication stains both the thrush lesions and the normal mucosa. This discoloration makes it difficult to distinguish the candidial infection and the superimposed irritative lesions that are secondary to the prolonged use of gentian violet. Eastman,2 in 1956, commented that gentian violet is an efficacious method for therapy for vaginal candidiasis. He reported, however, that local reactions References 1. Faber, H.K., and Dickey, L.: The Treatment of Thrush With Gentian Violet , JAMA 85:900-901 ( (Sept 19) ) 1925.Crossref 2. Eastman, N.J.: Williams Obstetrics , ed 11, New York: Appleton-Century-Crofts, Inc., 1956, p 344. 3. Parmelee, A.H.: The Mouth of the Newborn , Ped Clin N Amer , 3:847-854 ( (Nov) ) 1956. 4. Noojin, R.O.: " Pediatric Dermatology " in Shirkey, H.C.: Pediatric Therapy , St. Louis: C.V. Mosby Co., 1964, chap 89, p 794. 5. Slotkowski, E.L.: Formation of Mucous Membrane Lesions Secondary to Prolonged Use of One Per Cent Aqueous Gentian Violet , J Pediat 51:652-654 ( (Dec) ) 1957.Crossref 6. Wolff, O.H., et al: Thrush Oesophagitis With Pharyngeal Incoordination: Treated With Hydroxystilbamidine , Lancet 1:991-994 ( (May 14) ) 1955.Crossref 7. Sollmann, T.: A Manual of Pharmacology , ed 8, Philadelphia: W.B. Saunders Co., 1957, p 832. 8. Goodman, L.S., and Gilman, A.: The Pharmacological Basis of Therapeutics , ed 2, New York: Macmillan Co., 1956, p 1115.
American Journal of Diseases of Children – American Medical Association
Published: Jul 1, 1966