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MRI With Liver-Specific Contrast for Surveillance of Patients With Cirrhosis at High Risk of Hepatocellular Carcinoma

MRI With Liver-Specific Contrast for Surveillance of Patients With Cirrhosis at High Risk of... Key PointsQuestionIn patients with cirrhosis at high risk for hepatocellular carcinoma (HCC), is surveillance for HCC with magnetic resonance imaging (MRI) superior to surveillance by ultrasonography (US)? FindingsIn this prospective surveillance study of 407 patients with cirrhosis and a risk for developing HCC greater than 5% per year, screening MRI with liver-specific contrast resulted in a significantly higher HCC detection rate and lower a false-positive rate compared with US. Using MRI screening, most HCC cases detected were at a very early stage, which was associated with a high chance of curative treatments. MeaningIn high-risk patients with cirrhosis, surveillance by MRI with liver-specific contrast may allow earlier detection of HCC than US, improving clinical outcomes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Oncology American Medical Association

MRI With Liver-Specific Contrast for Surveillance of Patients With Cirrhosis at High Risk of Hepatocellular Carcinoma

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References (25)

Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved.
ISSN
2374-2437
eISSN
2374-2445
DOI
10.1001/jamaoncol.2016.3147
pmid
27657493
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIn patients with cirrhosis at high risk for hepatocellular carcinoma (HCC), is surveillance for HCC with magnetic resonance imaging (MRI) superior to surveillance by ultrasonography (US)? FindingsIn this prospective surveillance study of 407 patients with cirrhosis and a risk for developing HCC greater than 5% per year, screening MRI with liver-specific contrast resulted in a significantly higher HCC detection rate and lower a false-positive rate compared with US. Using MRI screening, most HCC cases detected were at a very early stage, which was associated with a high chance of curative treatments. MeaningIn high-risk patients with cirrhosis, surveillance by MRI with liver-specific contrast may allow earlier detection of HCC than US, improving clinical outcomes.

Journal

JAMA OncologyAmerican Medical Association

Published: Apr 22, 2017

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