Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins After Coronary Angiography

Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins... ORIGINAL CONTRIBUTION Mortality and Cardiovascular Events inPatientsTreatedWithHomocysteine-Lowering B Vitamins After Coronary Angiography A Randomized Controlled Trial Marta Ebbing, MD Context Observational studies have reported associations between circulating total Øyvind Bleie, MD, PhD homocysteine concentration and risk of cardiovascular disease. Oral administration of folic acid and vitamin B can lower plasma total homocysteine levels. Per Magne Ueland, MD, PhD Objective To assess the effect of treatment with folic acid and vitamin B and the Jan Erik Nordrehaug, MD, PhD effect of treatment with vitamin B as secondary prevention in patients with coronary Dennis W. Nilsen, MD, PhD artery disease or aortic valve stenosis. Stein Emil Vollset, MD, DrPH Design, Setting, and Participants Randomized, double-blind controlled trial con- ducted in the 2 university hospitals in western Norway in 1999-2006. A total of 3096 Helga Refsum, MD, PhD adult participants undergoing coronary angiography (20.5% female; mean age, 61.7 Eva Kristine Ringdal Pedersen, MD years) were randomized. At baseline, 59.3% had double- or triple-vessel disease, 83.7% Ottar Nyga ˚ rd, MD, PhD had stable angina pectoris, and 14.9% had acute coronary syndromes. Interventions Using a 2 2 factorial design, participants were randomly assigned BSERVATIONAL STUDIES to 1 of 4 groups receiving daily oral http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins After Coronary Angiography

Loading next page...
 
/lp/american-medical-association/mortality-and-cardiovascular-events-in-patients-treated-with-9iu0mtw5t7
Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.300.7.795
pmid
18714059
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Mortality and Cardiovascular Events inPatientsTreatedWithHomocysteine-Lowering B Vitamins After Coronary Angiography A Randomized Controlled Trial Marta Ebbing, MD Context Observational studies have reported associations between circulating total Øyvind Bleie, MD, PhD homocysteine concentration and risk of cardiovascular disease. Oral administration of folic acid and vitamin B can lower plasma total homocysteine levels. Per Magne Ueland, MD, PhD Objective To assess the effect of treatment with folic acid and vitamin B and the Jan Erik Nordrehaug, MD, PhD effect of treatment with vitamin B as secondary prevention in patients with coronary Dennis W. Nilsen, MD, PhD artery disease or aortic valve stenosis. Stein Emil Vollset, MD, DrPH Design, Setting, and Participants Randomized, double-blind controlled trial con- ducted in the 2 university hospitals in western Norway in 1999-2006. A total of 3096 Helga Refsum, MD, PhD adult participants undergoing coronary angiography (20.5% female; mean age, 61.7 Eva Kristine Ringdal Pedersen, MD years) were randomized. At baseline, 59.3% had double- or triple-vessel disease, 83.7% Ottar Nyga ˚ rd, MD, PhD had stable angina pectoris, and 14.9% had acute coronary syndromes. Interventions Using a 2 2 factorial design, participants were randomly assigned BSERVATIONAL STUDIES to 1 of 4 groups receiving daily oral

Journal

JAMAAmerican Medical Association

Published: Aug 20, 2008

References