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MORQUIO'S DISEASE ASSOCIATED WITH MENTAL DEFECT

MORQUIO'S DISEASE ASSOCIATED WITH MENTAL DEFECT Abstract A search of the literature has revealed that since Morquio's original description of a type of familial osseous dystrophy 43 cases of the condition have been reported in this country and abroad. Morquio1 described 4 cases in a family of 5 children. The fifth child of this family was free of osseous dystrophy, but he was mentally defective. The father and mother were first cousins. Morquio pointed out that the bony alterations do not appear until after the first year, when the child begins to walk. The changes are painless and progressive for several months, eventually becoming stationary and permanent. The thorax, the vertebral column and the limbs become deformed, the head remaining normal. These skeletal deformities are symmetric and cause difficulty in locomotion. The patient on first sight appears as if he suffered from Pott's disease. The genu valgum, flat feet, deformity of the vertebral column and weakness References 1. Morquio, L.: Sur une forme de dystrophie osseuse familiale , Arch. de méd. d. enf. 32:129-140 ( (March) ) 1929 2. Sur une forme de dystrophie osseuse familiale , Morquio Arch. de méd. d. enf. 38:5-24 ( (Jan.) ) 1935. 3. Valentin, B.: Knochensystemerkrankung (atypische Chrondrodystrophie, Ostrochondropathia multiplex) und sogenannte Platyspondylia generalisata , Zentralbl. f. Chir. 57:2038-2050 ( (Aug. 16) ) 1930. 4. Ruggles, H. E.: Dwarfism Due to Disordered Epiphysial Development , Am. J. Roentgenol. 25:91-94 ( (Jan.) ) 1931. 5. Meyer, F., and Brennemann, J.: A Rare Osseous Dystrophy (Morquio) , Am. J. Dis. Child. 43:123-135 ( (Jan.) ) 1932. 6. Coward, N. R., and Nemir, R. L.: Familial Osseous Dystrophy (Morquio's Disease) , Am. J. Dis. Child. 46:213-214 ( (July) ) 1933. 7. Barnett, E. G.: Morquio's Disease: Presentation of Two Cases , J. Pediat. 2:651-656 ( (June) ) 1933.Crossref 8. Brown, D. O.: Morquio's Disease , M. J. Australia 1:598-599 ( (May 15) ) 1933. 9. Davis, D. B., and Currier, F. P.: Morquio's Disease: Report of Two Cases , J. A. M. A. 102:2173-2176 ( (June 30) ) 1934.Crossref 10. Sainz de los Terreros, C., and Lacalle, E.: Enfermedad de Perthes o de Morquio? Heredo-distrofia osteo-articular coxo-femoral , Arch. españ. de pediat. 18:412-423 ( (July) 1934. 11. Giraud, G., and Bert, J. M.: La dystrophie osseuse de Morquio dans le cadre des hyperlaxités familiales , Rev. neurol. 63:845-856 ( (June) ) 1935. 12. Summerfeldt, P., and Brown, A.: Morquio's Disease , Arch. Dis. Childhood 11:221-229 ( (Aug.) ) 1936.Crossref 13. Freeman, J.: Morquio's Disease , Am. J. Dis. Child. 55:343-355 ( (Feb.) ) 1938. 14. Maróttoli, O. R., and de Azcuenaga, S.: Osteocondrodistrofia generalizata (enfermedad de Morquio) , Rev. méd. de Rosario 28:1265-1274 ( (Dec.) ) 1938. 15. Pohl, J. F.: Chondro-Osteodystrophy (Morquio's Disease) , J. Bone & Joint Surg. 21:187-192 ( (Jan.) ) 1939. 16. Crawford, T.: Morquio's Disease , Arch. Dis. Childhood 14:70-77 ( (March) ) 1939. 17. Jacobsen, A. W.: Hereditary Osteochondrodystrophia Deformans , J. A. M. A. 113:121-124 ( (July 5) ) 1939. 18. Brockema, H.: Rare Bone Diseases (Morquio's Disease) , Maandschr. v. kindergeneesk. 9:240-251 ( (March) ) 1940. 19. Depetris, P.: Enfermedad de Morquio , Arch. argent. de pediat. 11:369-376 ( (April) ) 1940. 20. Einhorn, N. H.; Moore, J. R.; Ostrum, H. W., and Rowntree, L. G.: Osteochondrodystrophia Deformans (Morquio's Disease) , Am. J. Dis. Child. 61: 776-794 ( (April) ) 1941. 21. Hubeny, N. J., and Delano, P. J.: Dyostosis Multiplex , Am. J. Roentgenol. 46:336-342 ( (Sept.) ) 1941. 22. Determinations of the androgen and estrogen content of the urine were made by Drs. Rinkel and Neustadt at the Research Laboratory, Boston State Hospital. 23. Veasey, C. A., Jr.: Ocular Findings Associated with Dysostosis Multiplex and Morquio's Disease , Arch. Ophth. 25:557-563 ( (April) ) 1941.Crossref 24. Warkany, J., and Mitchell, A. G.: Atypical Chondrodystrophy , J. Pediat. 4:734-745 ( (June) ) 1934.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

MORQUIO'S DISEASE ASSOCIATED WITH MENTAL DEFECT

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290090112007
Publisher site
See Article on Publisher Site

Abstract

Abstract A search of the literature has revealed that since Morquio's original description of a type of familial osseous dystrophy 43 cases of the condition have been reported in this country and abroad. Morquio1 described 4 cases in a family of 5 children. The fifth child of this family was free of osseous dystrophy, but he was mentally defective. The father and mother were first cousins. Morquio pointed out that the bony alterations do not appear until after the first year, when the child begins to walk. The changes are painless and progressive for several months, eventually becoming stationary and permanent. The thorax, the vertebral column and the limbs become deformed, the head remaining normal. These skeletal deformities are symmetric and cause difficulty in locomotion. The patient on first sight appears as if he suffered from Pott's disease. The genu valgum, flat feet, deformity of the vertebral column and weakness References 1. Morquio, L.: Sur une forme de dystrophie osseuse familiale , Arch. de méd. d. enf. 32:129-140 ( (March) ) 1929 2. Sur une forme de dystrophie osseuse familiale , Morquio Arch. de méd. d. enf. 38:5-24 ( (Jan.) ) 1935. 3. Valentin, B.: Knochensystemerkrankung (atypische Chrondrodystrophie, Ostrochondropathia multiplex) und sogenannte Platyspondylia generalisata , Zentralbl. f. Chir. 57:2038-2050 ( (Aug. 16) ) 1930. 4. Ruggles, H. E.: Dwarfism Due to Disordered Epiphysial Development , Am. J. Roentgenol. 25:91-94 ( (Jan.) ) 1931. 5. Meyer, F., and Brennemann, J.: A Rare Osseous Dystrophy (Morquio) , Am. J. Dis. Child. 43:123-135 ( (Jan.) ) 1932. 6. Coward, N. R., and Nemir, R. L.: Familial Osseous Dystrophy (Morquio's Disease) , Am. J. Dis. Child. 46:213-214 ( (July) ) 1933. 7. Barnett, E. G.: Morquio's Disease: Presentation of Two Cases , J. Pediat. 2:651-656 ( (June) ) 1933.Crossref 8. Brown, D. O.: Morquio's Disease , M. J. Australia 1:598-599 ( (May 15) ) 1933. 9. Davis, D. B., and Currier, F. P.: Morquio's Disease: Report of Two Cases , J. A. M. A. 102:2173-2176 ( (June 30) ) 1934.Crossref 10. Sainz de los Terreros, C., and Lacalle, E.: Enfermedad de Perthes o de Morquio? Heredo-distrofia osteo-articular coxo-femoral , Arch. españ. de pediat. 18:412-423 ( (July) 1934. 11. Giraud, G., and Bert, J. M.: La dystrophie osseuse de Morquio dans le cadre des hyperlaxités familiales , Rev. neurol. 63:845-856 ( (June) ) 1935. 12. Summerfeldt, P., and Brown, A.: Morquio's Disease , Arch. Dis. Childhood 11:221-229 ( (Aug.) ) 1936.Crossref 13. Freeman, J.: Morquio's Disease , Am. J. Dis. Child. 55:343-355 ( (Feb.) ) 1938. 14. Maróttoli, O. R., and de Azcuenaga, S.: Osteocondrodistrofia generalizata (enfermedad de Morquio) , Rev. méd. de Rosario 28:1265-1274 ( (Dec.) ) 1938. 15. Pohl, J. F.: Chondro-Osteodystrophy (Morquio's Disease) , J. Bone & Joint Surg. 21:187-192 ( (Jan.) ) 1939. 16. Crawford, T.: Morquio's Disease , Arch. Dis. Childhood 14:70-77 ( (March) ) 1939. 17. Jacobsen, A. W.: Hereditary Osteochondrodystrophia Deformans , J. A. M. A. 113:121-124 ( (July 5) ) 1939. 18. Brockema, H.: Rare Bone Diseases (Morquio's Disease) , Maandschr. v. kindergeneesk. 9:240-251 ( (March) ) 1940. 19. Depetris, P.: Enfermedad de Morquio , Arch. argent. de pediat. 11:369-376 ( (April) ) 1940. 20. Einhorn, N. H.; Moore, J. R.; Ostrum, H. W., and Rowntree, L. G.: Osteochondrodystrophia Deformans (Morquio's Disease) , Am. J. Dis. Child. 61: 776-794 ( (April) ) 1941. 21. Hubeny, N. J., and Delano, P. J.: Dyostosis Multiplex , Am. J. Roentgenol. 46:336-342 ( (Sept.) ) 1941. 22. Determinations of the androgen and estrogen content of the urine were made by Drs. Rinkel and Neustadt at the Research Laboratory, Boston State Hospital. 23. Veasey, C. A., Jr.: Ocular Findings Associated with Dysostosis Multiplex and Morquio's Disease , Arch. Ophth. 25:557-563 ( (April) ) 1941.Crossref 24. Warkany, J., and Mitchell, A. G.: Atypical Chondrodystrophy , J. Pediat. 4:734-745 ( (June) ) 1934.Crossref

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Sep 1, 1942

References

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