Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

MORQUIO'S DISEASE ASSOCIATED WITH MENTAL DEFECT

MORQUIO'S DISEASE ASSOCIATED WITH MENTAL DEFECT Abstract A search of the literature has revealed that since Morquio's original description of a type of familial osseous dystrophy 43 cases of the condition have been reported in this country and abroad. Morquio1 described 4 cases in a family of 5 children. The fifth child of this family was free of osseous dystrophy, but he was mentally defective. The father and mother were first cousins. Morquio pointed out that the bony alterations do not appear until after the first year, when the child begins to walk. The changes are painless and progressive for several months, eventually becoming stationary and permanent. The thorax, the vertebral column and the limbs become deformed, the head remaining normal. These skeletal deformities are symmetric and cause difficulty in locomotion. The patient on first sight appears as if he suffered from Pott's disease. The genu valgum, flat feet, deformity of the vertebral column and weakness References 1. Morquio, L.: Sur une forme de dystrophie osseuse familiale , Arch. de méd. d. enf. 32:129-140 ( (March) ) 1929 2. Sur une forme de dystrophie osseuse familiale , Morquio Arch. de méd. d. enf. 38:5-24 ( (Jan.) ) 1935. 3. Valentin, B.: Knochensystemerkrankung (atypische Chrondrodystrophie, Ostrochondropathia multiplex) und sogenannte Platyspondylia generalisata , Zentralbl. f. Chir. 57:2038-2050 ( (Aug. 16) ) 1930. 4. Ruggles, H. E.: Dwarfism Due to Disordered Epiphysial Development , Am. J. Roentgenol. 25:91-94 ( (Jan.) ) 1931. 5. Meyer, F., and Brennemann, J.: A Rare Osseous Dystrophy (Morquio) , Am. J. Dis. Child. 43:123-135 ( (Jan.) ) 1932. 6. Coward, N. R., and Nemir, R. L.: Familial Osseous Dystrophy (Morquio's Disease) , Am. J. Dis. Child. 46:213-214 ( (July) ) 1933. 7. Barnett, E. G.: Morquio's Disease: Presentation of Two Cases , J. Pediat. 2:651-656 ( (June) ) 1933.Crossref 8. Brown, D. O.: Morquio's Disease , M. J. Australia 1:598-599 ( (May 15) ) 1933. 9. Davis, D. B., and Currier, F. P.: Morquio's Disease: Report of Two Cases , J. A. M. A. 102:2173-2176 ( (June 30) ) 1934.Crossref 10. Sainz de los Terreros, C., and Lacalle, E.: Enfermedad de Perthes o de Morquio? Heredo-distrofia osteo-articular coxo-femoral , Arch. españ. de pediat. 18:412-423 ( (July) 1934. 11. Giraud, G., and Bert, J. M.: La dystrophie osseuse de Morquio dans le cadre des hyperlaxités familiales , Rev. neurol. 63:845-856 ( (June) ) 1935. 12. Summerfeldt, P., and Brown, A.: Morquio's Disease , Arch. Dis. Childhood 11:221-229 ( (Aug.) ) 1936.Crossref 13. Freeman, J.: Morquio's Disease , Am. J. Dis. Child. 55:343-355 ( (Feb.) ) 1938. 14. Maróttoli, O. R., and de Azcuenaga, S.: Osteocondrodistrofia generalizata (enfermedad de Morquio) , Rev. méd. de Rosario 28:1265-1274 ( (Dec.) ) 1938. 15. Pohl, J. F.: Chondro-Osteodystrophy (Morquio's Disease) , J. Bone & Joint Surg. 21:187-192 ( (Jan.) ) 1939. 16. Crawford, T.: Morquio's Disease , Arch. Dis. Childhood 14:70-77 ( (March) ) 1939. 17. Jacobsen, A. W.: Hereditary Osteochondrodystrophia Deformans , J. A. M. A. 113:121-124 ( (July 5) ) 1939. 18. Brockema, H.: Rare Bone Diseases (Morquio's Disease) , Maandschr. v. kindergeneesk. 9:240-251 ( (March) ) 1940. 19. Depetris, P.: Enfermedad de Morquio , Arch. argent. de pediat. 11:369-376 ( (April) ) 1940. 20. Einhorn, N. H.; Moore, J. R.; Ostrum, H. W., and Rowntree, L. G.: Osteochondrodystrophia Deformans (Morquio's Disease) , Am. J. Dis. Child. 61: 776-794 ( (April) ) 1941. 21. Hubeny, N. J., and Delano, P. J.: Dyostosis Multiplex , Am. J. Roentgenol. 46:336-342 ( (Sept.) ) 1941. 22. Determinations of the androgen and estrogen content of the urine were made by Drs. Rinkel and Neustadt at the Research Laboratory, Boston State Hospital. 23. Veasey, C. A., Jr.: Ocular Findings Associated with Dysostosis Multiplex and Morquio's Disease , Arch. Ophth. 25:557-563 ( (April) ) 1941.Crossref 24. Warkany, J., and Mitchell, A. G.: Atypical Chondrodystrophy , J. Pediat. 4:734-745 ( (June) ) 1934.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

MORQUIO'S DISEASE ASSOCIATED WITH MENTAL DEFECT

Download PDF
9 pages
Read Article

Loading next page...
 
/lp/american-medical-association/morquio-s-disease-associated-with-mental-defect-g7CkzuOi8l
Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290090112007
Publisher site
See Article on Publisher Site

Abstract

Abstract A search of the literature has revealed that since Morquio's original description of a type of familial osseous dystrophy 43 cases of the condition have been reported in this country and abroad. Morquio1 described 4 cases in a family of 5 children. The fifth child of this family was free of osseous dystrophy, but he was mentally defective. The father and mother were first cousins. Morquio pointed out that the bony alterations do not appear until after the first year, when the child begins to walk. The changes are painless and progressive for several months, eventually becoming stationary and permanent. The thorax, the vertebral column and the limbs become deformed, the head remaining normal. These skeletal deformities are symmetric and cause difficulty in locomotion. The patient on first sight appears as if he suffered from Pott's disease. The genu valgum, flat feet, deformity of the vertebral column and weakness References 1. Morquio, L.: Sur une forme de dystrophie osseuse familiale , Arch. de méd. d. enf. 32:129-140 ( (March) ) 1929 2. Sur une forme de dystrophie osseuse familiale , Morquio Arch. de méd. d. enf. 38:5-24 ( (Jan.) ) 1935. 3. Valentin, B.: Knochensystemerkrankung (atypische Chrondrodystrophie, Ostrochondropathia multiplex) und sogenannte Platyspondylia generalisata , Zentralbl. f. Chir. 57:2038-2050 ( (Aug. 16) ) 1930. 4. Ruggles, H. E.: Dwarfism Due to Disordered Epiphysial Development , Am. J. Roentgenol. 25:91-94 ( (Jan.) ) 1931. 5. Meyer, F., and Brennemann, J.: A Rare Osseous Dystrophy (Morquio) , Am. J. Dis. Child. 43:123-135 ( (Jan.) ) 1932. 6. Coward, N. R., and Nemir, R. L.: Familial Osseous Dystrophy (Morquio's Disease) , Am. J. Dis. Child. 46:213-214 ( (July) ) 1933. 7. Barnett, E. G.: Morquio's Disease: Presentation of Two Cases , J. Pediat. 2:651-656 ( (June) ) 1933.Crossref 8. Brown, D. O.: Morquio's Disease , M. J. Australia 1:598-599 ( (May 15) ) 1933. 9. Davis, D. B., and Currier, F. P.: Morquio's Disease: Report of Two Cases , J. A. M. A. 102:2173-2176 ( (June 30) ) 1934.Crossref 10. Sainz de los Terreros, C., and Lacalle, E.: Enfermedad de Perthes o de Morquio? Heredo-distrofia osteo-articular coxo-femoral , Arch. españ. de pediat. 18:412-423 ( (July) 1934. 11. Giraud, G., and Bert, J. M.: La dystrophie osseuse de Morquio dans le cadre des hyperlaxités familiales , Rev. neurol. 63:845-856 ( (June) ) 1935. 12. Summerfeldt, P., and Brown, A.: Morquio's Disease , Arch. Dis. Childhood 11:221-229 ( (Aug.) ) 1936.Crossref 13. Freeman, J.: Morquio's Disease , Am. J. Dis. Child. 55:343-355 ( (Feb.) ) 1938. 14. Maróttoli, O. R., and de Azcuenaga, S.: Osteocondrodistrofia generalizata (enfermedad de Morquio) , Rev. méd. de Rosario 28:1265-1274 ( (Dec.) ) 1938. 15. Pohl, J. F.: Chondro-Osteodystrophy (Morquio's Disease) , J. Bone & Joint Surg. 21:187-192 ( (Jan.) ) 1939. 16. Crawford, T.: Morquio's Disease , Arch. Dis. Childhood 14:70-77 ( (March) ) 1939. 17. Jacobsen, A. W.: Hereditary Osteochondrodystrophia Deformans , J. A. M. A. 113:121-124 ( (July 5) ) 1939. 18. Brockema, H.: Rare Bone Diseases (Morquio's Disease) , Maandschr. v. kindergeneesk. 9:240-251 ( (March) ) 1940. 19. Depetris, P.: Enfermedad de Morquio , Arch. argent. de pediat. 11:369-376 ( (April) ) 1940. 20. Einhorn, N. H.; Moore, J. R.; Ostrum, H. W., and Rowntree, L. G.: Osteochondrodystrophia Deformans (Morquio's Disease) , Am. J. Dis. Child. 61: 776-794 ( (April) ) 1941. 21. Hubeny, N. J., and Delano, P. J.: Dyostosis Multiplex , Am. J. Roentgenol. 46:336-342 ( (Sept.) ) 1941. 22. Determinations of the androgen and estrogen content of the urine were made by Drs. Rinkel and Neustadt at the Research Laboratory, Boston State Hospital. 23. Veasey, C. A., Jr.: Ocular Findings Associated with Dysostosis Multiplex and Morquio's Disease , Arch. Ophth. 25:557-563 ( (April) ) 1941.Crossref 24. Warkany, J., and Mitchell, A. G.: Atypical Chondrodystrophy , J. Pediat. 4:734-745 ( (June) ) 1934.Crossref

Journal

Archives of Neurology & Psychiatry – American Medical Association

Published: Sep 1, 1942

References

  • Sur une forme de dystrophie osseuse familiale
    Morquio , L.
  • Sur une forme de dystrophie osseuse familiale
    Morquio
  • Knochensystemerkrankung (atypische Chrondrodystrophie, Ostrochondropathia multiplex) und sogenannte Platyspondylia generalisata
    Valentin , B.
  • Dwarfism Due to Disordered Epiphysial Development
    Ruggles , H. E.
  • A Rare Osseous Dystrophy (Morquio)
    Meyer , F., and Brennemann, J.
  • Familial Osseous Dystrophy (Morquio's Disease)
    Coward , N. R., and Nemir, R. L.
  • Morquio's Disease: Presentation of Two Cases
    Barnett , E. G.
  • Morquio's Disease
    Brown , D. O.
  • Morquio's Disease: Report of Two Cases
    Davis , D. B., and Currier, F. P.
  • Enfermedad de Perthes o de Morquio? Heredo-distrofia osteo-articular coxo-femoral
    Sainz de los Terreros , C., and Lacalle, E.
  • La dystrophie osseuse de Morquio dans le cadre des hyperlaxités familiales
    Giraud , G., and Bert, J. M.
  • Morquio's Disease
    Summerfeldt , P., and Brown, A.
  • Morquio's Disease
    Freeman , J.
  • Osteocondrodistrofia generalizata (enfermedad de Morquio)
    Maróttoli , O. R., and de Azcuenaga, S.
  • Chondro-Osteodystrophy (Morquio's Disease)
    Pohl , J. F.
  • Morquio's Disease
    Crawford , T.
  • Hereditary Osteochondrodystrophia Deformans
    Jacobsen , A. W.
  • Rare Bone Diseases (Morquio's Disease)
    Brockema , H.
  • Enfermedad de Morquio
    Depetris , P.
  • Osteochondrodystrophia Deformans (Morquio's Disease)
    Einhorn , N. H.; Moore, J. R.; Ostrum, H. W., and Rowntree, L. G.
  • Dyostosis Multiplex
    Hubeny , N. J., and Delano, P. J.
  • Ocular Findings Associated with Dysostosis Multiplex and Morquio's Disease
    Veasey , C. A., Jr.
  • Atypical Chondrodystrophy
    Warkany , J., and Mitchell, A. G.

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial