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Morphologic Changes in Epidermis of PUVA-Treated Patients With Psoriasis With or Without a History of Arsenic Therapy

Morphologic Changes in Epidermis of PUVA-Treated Patients With Psoriasis With or Without a... Abstract • The uninvolved skin of patients with psoriasis was examined microscopically. Atypical nuclear features in keratinocytes and melanocytes were found in about half of the patients. The patients treated with psoralens and UV-A (PUVA) had significantly more of these changes than did patients without PUVA treatment, and the risk was dose dependent. Previous arsenic treatment and x-ray irradiation seemed to have a similar effect. The changes may have been due to the shortwave UV range of the light source. (Arch Dermatol 1983;119:904-909) References 1. Stern RS, Thibodeau LA, Kleinerman RA, et al: Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis . N Engl J Med 1979;300:809-813.Crossref 2. Hönigsmann H, Wolff K, Gschnait F, et al: Keratoses and nonmelanoma skin tumors in long-term photochemotherapy (PUVA) . J Am Acad Dermatol 1980;3:406-414.Crossref 3. Roenigk HH, Caro WA: Skin cancer in the PUVA-48 cooperative study . J Am Acad Dermatol 1981;4:319-324.Crossref 4. Cox AJ, Abel EA: Epidermal dystrophy: Occurrence after psoriasis therapy with psoralen and long-wave ultraviolet light . Arch Dermatol 1979;115:567-570.Crossref 5. Hofmann C, Plewig G, Braun-Falco O: Bowenoid lesions, Bowen's disease and keratoacanthomas in long-term PUVA-treated patients . Br J Dermatol 1979;101:685-692.Crossref 6. Gschnait F, Wolff K, Hönigsmann H, et al: Long-term photochemotherapy: Histopathological and immunofluorescence observations in 243 patients . Br J Dermatol 1980;103:11-22.Crossref 7. Hannuksela M, Karvonen J: Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis . Br J Dermatol 1978;99:703-709.Crossref 8. Arsenic and Arsenic Compounds , IARC Monographs, No. (23) . Lyons, France, IARC Working Group, 1980, pp 39-142. 9. Bishop SC, Gray B, Abel EA: Absence of unscheduled DNA synthesis after UVB exposure in the uninvolved skin of psoriatic patients completing a course of PUVA therapy . J Invest Dermatol 1980;74:255. 10. Wolff K, Fitzpatrick TB, Parrish JA, et al: Photochemotherapy for psoriasis with orally administered methoxsalen . Arch Dermatol 1976;112:943-950.Crossref 11. Kanerva L, Niemi K-M, Lassus A: Hyperpigmentation and hypopigmentation of the skin after long-term PUVA therapy . J Cutan Pathol 1981;8:199-213.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Morphologic Changes in Epidermis of PUVA-Treated Patients With Psoriasis With or Without a History of Arsenic Therapy

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650350032010
Publisher site
See Article on Publisher Site

Abstract

Abstract • The uninvolved skin of patients with psoriasis was examined microscopically. Atypical nuclear features in keratinocytes and melanocytes were found in about half of the patients. The patients treated with psoralens and UV-A (PUVA) had significantly more of these changes than did patients without PUVA treatment, and the risk was dose dependent. Previous arsenic treatment and x-ray irradiation seemed to have a similar effect. The changes may have been due to the shortwave UV range of the light source. (Arch Dermatol 1983;119:904-909) References 1. Stern RS, Thibodeau LA, Kleinerman RA, et al: Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis . N Engl J Med 1979;300:809-813.Crossref 2. Hönigsmann H, Wolff K, Gschnait F, et al: Keratoses and nonmelanoma skin tumors in long-term photochemotherapy (PUVA) . J Am Acad Dermatol 1980;3:406-414.Crossref 3. Roenigk HH, Caro WA: Skin cancer in the PUVA-48 cooperative study . J Am Acad Dermatol 1981;4:319-324.Crossref 4. Cox AJ, Abel EA: Epidermal dystrophy: Occurrence after psoriasis therapy with psoralen and long-wave ultraviolet light . Arch Dermatol 1979;115:567-570.Crossref 5. Hofmann C, Plewig G, Braun-Falco O: Bowenoid lesions, Bowen's disease and keratoacanthomas in long-term PUVA-treated patients . Br J Dermatol 1979;101:685-692.Crossref 6. Gschnait F, Wolff K, Hönigsmann H, et al: Long-term photochemotherapy: Histopathological and immunofluorescence observations in 243 patients . Br J Dermatol 1980;103:11-22.Crossref 7. Hannuksela M, Karvonen J: Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis . Br J Dermatol 1978;99:703-709.Crossref 8. Arsenic and Arsenic Compounds , IARC Monographs, No. (23) . Lyons, France, IARC Working Group, 1980, pp 39-142. 9. Bishop SC, Gray B, Abel EA: Absence of unscheduled DNA synthesis after UVB exposure in the uninvolved skin of psoriatic patients completing a course of PUVA therapy . J Invest Dermatol 1980;74:255. 10. Wolff K, Fitzpatrick TB, Parrish JA, et al: Photochemotherapy for psoriasis with orally administered methoxsalen . Arch Dermatol 1976;112:943-950.Crossref 11. Kanerva L, Niemi K-M, Lassus A: Hyperpigmentation and hypopigmentation of the skin after long-term PUVA therapy . J Cutan Pathol 1981;8:199-213.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1983

References