Abstract Among the many unusual and severe infections due to Candida albicans that have been reported are thrush of the umbilical cord (intrauterine infection), esophageal involvement without oral involvement, infection of the conjunctiva and cornea, intraocular lesions after cataract surgery, peritonitis, empyema, and monilial cystitis.1-7 In 1950 Hauser and Rothmans reviewed the world's literature and added an additional case of monilial granuloma, a peculiar and often fatal form of candidiasis. Since that report 4 more cases have been recorded, making a total of 18 in all. This paper reports a case of monilial granuloma having the unique features of hypergammaglobulinemia and an associated Microsporum audouini infection. Report of a Case A 12-year-old Negro girl presented with a bizarre eruption involving face, scalp, fingernails, mouth, and arms of about 8 years' duration (Fig. 1). The history was not felt to be entirely reliable, but the parents stated that the mouth References 1. Trade-mark Fungizone (E. R. Squibb & Sons). 2. Hydrophilic ointment base containing alcohols and esters of cholesterol in aliphatic hydrocarbons. 3. Belter, L. F.: Thrush of the Umbilical Cord , Obstet. Gynec. (NY) 14:796-798 ( (Dec.) ) 1959. 4. Marsh, A. P.: Esophageal Moniliasis , Amer. J. Roentgenol. 82:1063-1066 ( (Dec.) ) 1959. 5. Mathur, S. P.: Ocular Complications in Cutaneous Moniliasis , Ophthalmologica 139:112-114 ( (Feb.) ) 1960.Crossref 6. Foster, J. B.; Almeda, E.; Littman, M. L., and Wilson, M. E.: Some Intraocular and Conjunctival Effects of Amphotericin B in Man and in the Rabbit , A.M.A. Arch. Ophthal. 60:555-564 ( (Oct.) ) 1958.Crossref 7. Ohlwiler, D. A., and Bricker, E. M.: Candida Albicans Peritonitis Successfully Treated with Amphotericin B , New Engl. J. Med. 260:488-489 ( (March 5) ) 1957.Crossref 8. Findley, C. W., Jr., and Kleinfeld, G.: Monilial Empyema Treated Successfully with Intrapleural Instillations of Amphotericin B , J. Thor. Cardiov. Surg. 38:244-247 ( (Aug.) ) 1959. 9. Goldman, H. J.; Littman, M. L.; Oppenheimer, G. D., and Glickman, S. I.: Monilial Cystitis—Effective Treatment with Instillations of Amphotericin B , J.A.M.A. 174:359-362 ( (Sept. 24) ) 1960.Crossref 10. Hauser, F. V., and Rothman, S.: Monilial Granuloma: Report of a Case and Review of the Literature , Arch. Derm. Syph. 61:297-310 ( (Feb.) ) 1950.Crossref 11. Pluss, J. M., and Kadas, L.: Case of Monilial Granulomas Associated with Widespread Superficial Moniliasis and Epidermophytosis , J. Invest. Derm. 23:317-328 ( (Nov.) ) 1954.Crossref 12. Papazian, C. E., and Koch, R.: Monilial Granuloma with Hypothroidism: Report of a Case Treated with Amphotericin B , New Engl. J. Med. 262:16-18 ( (Jan. 7) ) 1960.Crossref 13. Blank, H.; Sagami, S.; Boyd, C., and Roth, F. J., Jr.: The Pathogenesis of Superficial Fungous Infections in Cultured Human Skin , A.M.A. Arch. Derm. 79:524-535 ( (May) ) 1959.Crossref 14. Roth, F. J., Jr.; Boyd, C.; Sagami, S., and Blank, H.: An Evaluation of the Fungistatic Activity of Serum , J. Invest. Derm. 32:549-556 ( (May) ) 1959.Crossref 15. Costello, M. J.; Defeo, C. P., Jr., and Littman, M. L.: Chromoblastomycosis Treated with Local Infiltration of Amphotericin B Solution , A.M.A. Arch. Derm. 79:184-193 ( (Feb.) ) 1959.Crossref 16. Newcomer, V. D.; Sternberg, T. H.; Wright, E. T., and Reisner, R. M.: Current Status of Amphotericin B in the Treatment of the Systemic Fungus Infections , J. Chron. Dis. 9:353-374 ( (April) ) 1959.Crossref 17. Fraser, W. M., and Knox, J. M.: Amphotericin as a Topical Antifungal Antibiotic , A.M.A. Arch. Derm. 80:436-438 ( (Oct.) ) 1959.Crossref 18. Manchester, P. T., Jr., and Georg, L. K.: Corneal Ulcer Due to Candida Parapsilosis (C. Parakrusei) , J.A.M.A. 171:1339-1341 ( (Nov. 7) ) 1959.Crossref
Archives of Dermatology – American Medical Association
Published: Aug 1, 1961
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