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MONGOLISM AND CONGENITAL LEUKEMIA

MONGOLISM AND CONGENITAL LEUKEMIA Because congenital leukemia has been reported only rarely and its association with mongolism is even less common,1 it is thought worth while to report the cases of two mongoloid infants in whom blood dyscrasias occurred. REPORT OF CASES Case 1.— This infant girl, the third child of a 38-year-old mother whose previous children were normal, was born on July 16, 1952. The only abnormality of gestation was polyhydramnios. After labor was induced approximately three weeks beyond term the child was born asphyxiated. She weighed 3,632 gm. and showed generalized edema that was especially prominent on her head and face. After tracheal aspiration she breathed promptly, but eight hours after birth she became listless, apathetic, and jaundiced. Injection of nikethamide was followed by a mild generalized seizure. The liver and later the spleen progressively enlarged so that at 33 hours the liver had descended to the umbilicus and the spleen http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

MONGOLISM AND CONGENITAL LEUKEMIA

Schunk, George J.; Lehman, William L.
JAMA , Volume 155 (3) – May 15, 1954
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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1954.73690210004006b
Publisher site
See Article on Publisher Site

Abstract

Because congenital leukemia has been reported only rarely and its association with mongolism is even less common,1 it is thought worth while to report the cases of two mongoloid infants in whom blood dyscrasias occurred. REPORT OF CASES Case 1.— This infant girl, the third child of a 38-year-old mother whose previous children were normal, was born on July 16, 1952. The only abnormality of gestation was polyhydramnios. After labor was induced approximately three weeks beyond term the child was born asphyxiated. She weighed 3,632 gm. and showed generalized edema that was especially prominent on her head and face. After tracheal aspiration she breathed promptly, but eight hours after birth she became listless, apathetic, and jaundiced. Injection of nikethamide was followed by a mild generalized seizure. The liver and later the spleen progressively enlarged so that at 33 hours the liver had descended to the umbilicus and the spleen

Journal

JAMA – American Medical Association

Published: May 15, 1954

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