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Molluscum Contagiosum: A Clinicopathologic Study

Molluscum Contagiosum: A Clinicopathologic Study Abstract Clinical diagnosis of molluscum contagiosum has been considered easy by most dermatology textbooks. The semiglobular, elevated, firm, and yellow, waxy-appearing lesions with central umbilication from which a milky curdlike substance can be expressed are described as characteristic features. Besides this classical form, molluscum contagiosum presents a variety of unusual clinical pictures which produce diagnostic difficulties. It is in such cases that the clinician seeks assistance from the histopathologist, often without suspecting the correct diagnosis. In this paper, 42 cases of molluscum contagiosum found among 20,000 consecutive skin biopsy specimens are reviewed, and special reference is made to the unusual clinical and histological findings of this virus infection. Of these 42 cases, 38 had clinical diagnoses as follows: molluscum contagiosum, 8; basal-cell epithelioma, 12; verruca vulgaris, 5; histiocytoma, 3; keratoacanthoma, 2; intradermal nevus, 2; solitary Darier's disease, 2; and nevoxanthoendothelioma, syringoma, epithelial nevi, and sebaceous adenoma, 1 each. The remaining 4 References 1. Meer Maastricht, B. C. J., and Gomperts, C. E.: Molluscum Contagiosum Giganteum , Amer. J. Ophthal. 33:965-967, 1950. 2. Curtin, B. J., and Theodore, F. H.: Ocular Molluscum Contagiosum , Amer. J. Ophthal. 39: 302-307, 1955. 3. Quill, T. H.: Molluscum Contagiosum of Eyelid and Cornea , Proc. Mayo Clin. 15:139-142, 1940. 4. Gifford, S. R., and Gifford, H.: Molluscum Conjunctivitis , Arch. Ophthal. 50:226-233, 1921. 5. Gomez, M.: Sobre un caso de molluscum contagiosum con rara localizacion conjunctival , Arch. Soc. Oftal. Hispano-Amer. 13:684-685, 1953. 6. Tobias, N.: Solitary Molluscum Contagiosum in Adults , A.M.A. Arch. Dermat. Syph. 64:208-209, 1951.Crossref 7. Tzanck, A.; Sidi, E., and Melki, G.: Trois cas de molluscum contagiosum unique, avec réaction ganglionnaire importante (importance du cyto-diagnostic) , Ann. Dermat. Syph. (Par.) 10: 263-267, 1950. 8. Ferrari, A.: Sopra un caso singolare di mullusco contagioso gigante in un capezzolo di un uomo , Dermosifilografo 24:445-455, 1949. 9. Whitfield, A.: Clinical Notes on Molluscum Contagiosum Miliare , Brit. J. Dermat. 41:10-12, 1929.Crossref 10. White, C.: Molluscum Contagiosum of the Scalp , Arch. Dermat. Syph. 21:180-181, 1930.Crossref 11. Hill, W. R., and Messina, S. J.: Molluscum Contagiosum of the Scalp , Arch. Dermat. Syph. 60:633-635, 1949.Crossref 12. Sommerville, J.: Molluscum contagiosum and M. & B. 693 , Brit. J. Dermat. 53:255-257, 1941.Crossref 13. Tanissa, A.: "Molluscum contagiosum" do couro cabeludo , Gaz. Med. Port. 3:394-395, 1950. 14. DeOreo, G. A.; Johnson, H. H., Jr., and Binkley, G. W.: An Eczematous Reaction Associated with Molluscum Contagiosum , A.M.A. Arch. Dermat. 74:344-348, 1956.Crossref 15. Allen, C. W.: A Case of Molluscum Contagiosum , J. Cutan. Genito-Urin. Dis. 13:75, 1895. 16. Abraham, P. S.: Note on Some Varieties of Molluscum Contagiosum , Brit. Med. J. 2:851, 1910. 17. Pinkus, H., and Frisch, D.: Inflammatory Reactions to Molluscum Contagiosum, Possibly of Immunologic Nature , J. Invest. Dermat. 13: 289-294, 1949.Crossref 18. Goldschmidt, H., and Kligman, A. M.: Experimental Inoculation of Humans with EctodermoTropic Viruses , J. Invest. Dermat. 31:175-182, 1958.Crossref 19. Carteaud, A. J.: Une tumeur cutanee benigne d'origine virale: Le molluscum contagiosum , Sem. Hop. Paris 43:327-330, 1955. 20. Kuta's paper on "Molluscum (epithelioma) Contagiosum Inflammatum" was published in Čsl. Dermatologie 35:405-410, 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Molluscum Contagiosum: A Clinicopathologic Study

Archives of Dermatology , Volume 84 (1) – Jul 1, 1961

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1961.01580130129020
Publisher site
See Article on Publisher Site

Abstract

Abstract Clinical diagnosis of molluscum contagiosum has been considered easy by most dermatology textbooks. The semiglobular, elevated, firm, and yellow, waxy-appearing lesions with central umbilication from which a milky curdlike substance can be expressed are described as characteristic features. Besides this classical form, molluscum contagiosum presents a variety of unusual clinical pictures which produce diagnostic difficulties. It is in such cases that the clinician seeks assistance from the histopathologist, often without suspecting the correct diagnosis. In this paper, 42 cases of molluscum contagiosum found among 20,000 consecutive skin biopsy specimens are reviewed, and special reference is made to the unusual clinical and histological findings of this virus infection. Of these 42 cases, 38 had clinical diagnoses as follows: molluscum contagiosum, 8; basal-cell epithelioma, 12; verruca vulgaris, 5; histiocytoma, 3; keratoacanthoma, 2; intradermal nevus, 2; solitary Darier's disease, 2; and nevoxanthoendothelioma, syringoma, epithelial nevi, and sebaceous adenoma, 1 each. The remaining 4 References 1. Meer Maastricht, B. C. J., and Gomperts, C. E.: Molluscum Contagiosum Giganteum , Amer. J. Ophthal. 33:965-967, 1950. 2. Curtin, B. J., and Theodore, F. H.: Ocular Molluscum Contagiosum , Amer. J. Ophthal. 39: 302-307, 1955. 3. Quill, T. H.: Molluscum Contagiosum of Eyelid and Cornea , Proc. Mayo Clin. 15:139-142, 1940. 4. Gifford, S. R., and Gifford, H.: Molluscum Conjunctivitis , Arch. Ophthal. 50:226-233, 1921. 5. Gomez, M.: Sobre un caso de molluscum contagiosum con rara localizacion conjunctival , Arch. Soc. Oftal. Hispano-Amer. 13:684-685, 1953. 6. Tobias, N.: Solitary Molluscum Contagiosum in Adults , A.M.A. Arch. Dermat. Syph. 64:208-209, 1951.Crossref 7. Tzanck, A.; Sidi, E., and Melki, G.: Trois cas de molluscum contagiosum unique, avec réaction ganglionnaire importante (importance du cyto-diagnostic) , Ann. Dermat. Syph. (Par.) 10: 263-267, 1950. 8. Ferrari, A.: Sopra un caso singolare di mullusco contagioso gigante in un capezzolo di un uomo , Dermosifilografo 24:445-455, 1949. 9. Whitfield, A.: Clinical Notes on Molluscum Contagiosum Miliare , Brit. J. Dermat. 41:10-12, 1929.Crossref 10. White, C.: Molluscum Contagiosum of the Scalp , Arch. Dermat. Syph. 21:180-181, 1930.Crossref 11. Hill, W. R., and Messina, S. J.: Molluscum Contagiosum of the Scalp , Arch. Dermat. Syph. 60:633-635, 1949.Crossref 12. Sommerville, J.: Molluscum contagiosum and M. & B. 693 , Brit. J. Dermat. 53:255-257, 1941.Crossref 13. Tanissa, A.: "Molluscum contagiosum" do couro cabeludo , Gaz. Med. Port. 3:394-395, 1950. 14. DeOreo, G. A.; Johnson, H. H., Jr., and Binkley, G. W.: An Eczematous Reaction Associated with Molluscum Contagiosum , A.M.A. Arch. Dermat. 74:344-348, 1956.Crossref 15. Allen, C. W.: A Case of Molluscum Contagiosum , J. Cutan. Genito-Urin. Dis. 13:75, 1895. 16. Abraham, P. S.: Note on Some Varieties of Molluscum Contagiosum , Brit. Med. J. 2:851, 1910. 17. Pinkus, H., and Frisch, D.: Inflammatory Reactions to Molluscum Contagiosum, Possibly of Immunologic Nature , J. Invest. Dermat. 13: 289-294, 1949.Crossref 18. Goldschmidt, H., and Kligman, A. M.: Experimental Inoculation of Humans with EctodermoTropic Viruses , J. Invest. Dermat. 31:175-182, 1958.Crossref 19. Carteaud, A. J.: Une tumeur cutanee benigne d'origine virale: Le molluscum contagiosum , Sem. Hop. Paris 43:327-330, 1955. 20. Kuta's paper on "Molluscum (epithelioma) Contagiosum Inflammatum" was published in Čsl. Dermatologie 35:405-410, 1960.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1961

References

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