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MODIFICATION OF THERAPY WITH GOLD COMPOUNDS IN LUPUS ERYTHEMATOSUS: PRELIMINARY COMMUNICATION

MODIFICATION OF THERAPY WITH GOLD COMPOUNDS IN LUPUS ERYTHEMATOSUS: PRELIMINARY COMMUNICATION Abstract During the last few years there has been a great advance in the treatment for lupus erythematosus with various gold compounds. Much has been written concerning the toxicity of these preparations, all of which have been administered by the intravenous method. Many cases have been encountered in which more than 100 intravenous injections have failed to produce cure, and others in which a few carefully given doses were followed by more or less serious reactions, exfoliating dermatitis and, in a number of instances, death. To avoid these complications, experimentation was begun to determine a method of giving this valuable group of compounds which would be equally or more efficient than the intravenous route, but which would not be as hazardous. Furthermore, it seemed to us that if the beneficial results of gold compounds in lupus erythematosus depended on their reaching the diseased areas, injection directly into the lesion http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

MODIFICATION OF THERAPY WITH GOLD COMPOUNDS IN LUPUS ERYTHEMATOSUS: PRELIMINARY COMMUNICATION

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Publisher
American Medical Association
Copyright
Copyright © 1931 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1931.01450010115011
Publisher site
See Article on Publisher Site

Abstract

Abstract During the last few years there has been a great advance in the treatment for lupus erythematosus with various gold compounds. Much has been written concerning the toxicity of these preparations, all of which have been administered by the intravenous method. Many cases have been encountered in which more than 100 intravenous injections have failed to produce cure, and others in which a few carefully given doses were followed by more or less serious reactions, exfoliating dermatitis and, in a number of instances, death. To avoid these complications, experimentation was begun to determine a method of giving this valuable group of compounds which would be equally or more efficient than the intravenous route, but which would not be as hazardous. Furthermore, it seemed to us that if the beneficial results of gold compounds in lupus erythematosus depended on their reaching the diseased areas, injection directly into the lesion

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Jul 1, 1931

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