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Modifiable Lifestyle Factors in Alzheimer Disease

Modifiable Lifestyle Factors in Alzheimer Disease Opinion EDITORIAL An Opportunity to Transform the Therapeutic Landscape Through Transdisciplinary Collaboration Timothy J. Hohman, PhD; Catherine C. Kaczorowski, PhD port social policies that directly benefit vulnerable and While the field of Alzheimer disease (AD) continues to evalu- ate therapeutic regimens that begin decades before clinical marginalized individuals in our society who may not have ac- symptoms, results from Oveisgharan et al reported in this cess to resources that promote cognitive enrichment. Such issue of JAMA Neurology add to a growing body of evidence policy reform has critical implications for reducing the bur- suggesting that modifiable den of age-related cognitive impairment and would counter- lifestyle factors in childhood act systemic injustices that perpetuate health inequities and Related article page 1217 may provide some protec- contribute to the well-documented disparities in AD. In fact, 2 3 tion against disease. In 1996, Snowdon et al published data previous work has indicated that the benefits of midlife cog- from the Nun Study highlighting that early-life linguistic abil- nitive activity are actually greatest in those with lower edu- ity was strongly associated with late-life cognitive decline and cational or occupational attainment. Therefore, focusing early AD neuropathology. This transformative work demonstrated and midlife interventions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Modifiable Lifestyle Factors in Alzheimer Disease

Hohman, Timothy J.; Kaczorowski, Catherine C.
JAMA Neurology , Volume 77 (10) – Oct 29, 2020
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References (20)

Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2020.1114
Publisher site
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Abstract

Opinion EDITORIAL An Opportunity to Transform the Therapeutic Landscape Through Transdisciplinary Collaboration Timothy J. Hohman, PhD; Catherine C. Kaczorowski, PhD port social policies that directly benefit vulnerable and While the field of Alzheimer disease (AD) continues to evalu- ate therapeutic regimens that begin decades before clinical marginalized individuals in our society who may not have ac- symptoms, results from Oveisgharan et al reported in this cess to resources that promote cognitive enrichment. Such issue of JAMA Neurology add to a growing body of evidence policy reform has critical implications for reducing the bur- suggesting that modifiable den of age-related cognitive impairment and would counter- lifestyle factors in childhood act systemic injustices that perpetuate health inequities and Related article page 1217 may provide some protec- contribute to the well-documented disparities in AD. In fact, 2 3 tion against disease. In 1996, Snowdon et al published data previous work has indicated that the benefits of midlife cog- from the Nun Study highlighting that early-life linguistic abil- nitive activity are actually greatest in those with lower edu- ity was strongly associated with late-life cognitive decline and cational or occupational attainment. Therefore, focusing early AD neuropathology. This transformative work demonstrated and midlife interventions

Journal

JAMA Neurology – American Medical Association

Published: Oct 29, 2020

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