Abstract • A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, and isohemagglutinin titers. A marked mitogenic response of her cultured lymphocytes to Toxocara antigen but not to Ascaris antigen was found. A neutrophil chemotactic abnormality to Escherichia coli culture filtrates and zymosan-activated sera was also demonstrated, which partially corrected after she was treated with diethylcarbamazine citrate. (Am J Dis Child 134:845-847, 1980) References 1. Huntley CC, Costas MC, Lyerly A: Visceral larva migrans syndrome: Clinical characteristics and immunodiagnostic studies in 51 patients . Pediatrics 36:523-536, 1965. 2. Mok CH: Visceral larva migrans: A discussion based on review of the literature . Clin Pediatr 7:565-573, 1968.Crossref 3. Hogarth-Scott RS, Johansson SGO, Bennich H: Antibodies to Toxocara in the sera of visceral larva migrans patients: The significance of raised levels of IgE . Clin Exp Immunol 5:619-625, 1969. 4. Patterson R, Huntley CC, Roberts M, et al: Visceral larva migrans: Immunoglobulins, precipitating antibodies and detection of IgG and IgM antibodies against Toxocara antigen . Am J Trop Med Hyg 24:465-470, 1975. 5. Boyden SV: The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes . J Exp Med 115:453-466, 1962.Crossref 6. Hill HR, Quie PG: Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections . Lancet 1:183-187, 1974.Crossref 7. Bowers TK, Craddock PR, Jacob HS: Acquired granulocyte abnormality during drug allergic reactions: Possible role of complement activation . Blood 49:3-8, 1977. 8. Craddock PR, Fehr J, Jacob HS: Complement-mediated granulocyte dysfunction in paroxysmal nocturnal hemoglobinuria . Blood 47:931-940, 1976. 9. Fontan G: Defective neutrophil chemotaxis and hyperimmunoglobulinemia E: A reversible defect? Acta Pediatr Scand 65:509-511, 1976.Crossref 10. Buckley RH, Wray BB, Belmaker EZ: Extreme hyperimmunoglobulinemia E and undue susceptibility to infection . Pediatrics 49:59-70, 1972.
American Journal of Diseases of Children – American Medical Association
Published: Sep 1, 1980
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