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Misinterpretation of Study Data—Reply

Misinterpretation of Study Data—Reply Letters Author Affiliations: Department of Medicine (Neurology), University of COMMENT & RESPONSE Alberta, Edmonton, Alberta, Canada (Power, Branton); Department of Neuroscience, University of Groningen, University Medical Center Groningen, Misinterpretation of Study Data Groningen, the Netherlands (Laman). To the Editor The recent Wilson et al study reported that next- Corresponding Author: Christopher Power, MD, Departments of Medicine generation sequencing served as a diagnostic tool for neurologi- (Neurology), Medical Microbiology & Immunology, and Psychiatry, 6-11 Heritage 2,3 cal infections. It also posited that data from our group reflected Medical Research Centre, University of Alberta, Edmonton, AB T6G 2S2, Canada (chris.power@ualberta.ca). a contamination of the molecular biological reagents and not the Published Online: November 26, 2018. doi:10.1001/jamaneurol.2018.3668 presence of bacteria in surgically resected and autopsied brains. Conflict of Interest Disclosures: None reported. We take issue with this latter conclusion because it is based on 1. Wilson MR, O’Donovan BD, Gelfand JM, et al. Chronic meningitis investigated several mistaken interpretations of our data. via metagenomic next-generation sequencing. JAMA Neurol. 2018;75(8):947-955. Unlike Wilson et al’s contention that we applied deep se- doi:10.1001/jamaneurol.2018.0463 quencing to RNA that was derived from cerebrospinal fluid, 2. Branton WG, Ellestad KK, Maingat F, et al. Brain microbial populations in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Misinterpretation of Study Data—Reply

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2018.3671
Publisher site
See Article on Publisher Site

Abstract

Letters Author Affiliations: Department of Medicine (Neurology), University of COMMENT & RESPONSE Alberta, Edmonton, Alberta, Canada (Power, Branton); Department of Neuroscience, University of Groningen, University Medical Center Groningen, Misinterpretation of Study Data Groningen, the Netherlands (Laman). To the Editor The recent Wilson et al study reported that next- Corresponding Author: Christopher Power, MD, Departments of Medicine generation sequencing served as a diagnostic tool for neurologi- (Neurology), Medical Microbiology & Immunology, and Psychiatry, 6-11 Heritage 2,3 cal infections. It also posited that data from our group reflected Medical Research Centre, University of Alberta, Edmonton, AB T6G 2S2, Canada (chris.power@ualberta.ca). a contamination of the molecular biological reagents and not the Published Online: November 26, 2018. doi:10.1001/jamaneurol.2018.3668 presence of bacteria in surgically resected and autopsied brains. Conflict of Interest Disclosures: None reported. We take issue with this latter conclusion because it is based on 1. Wilson MR, O’Donovan BD, Gelfand JM, et al. Chronic meningitis investigated several mistaken interpretations of our data. via metagenomic next-generation sequencing. JAMA Neurol. 2018;75(8):947-955. Unlike Wilson et al’s contention that we applied deep se- doi:10.1001/jamaneurol.2018.0463 quencing to RNA that was derived from cerebrospinal fluid, 2. Branton WG, Ellestad KK, Maingat F, et al. Brain microbial populations in

Journal

JAMA NeurologyAmerican Medical Association

Published: Jan 26, 2019

References