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Mirror Movements in Patients With the Klippel-Feil Syndrome: Neuropathologic Observations

Mirror Movements in Patients With the Klippel-Feil Syndrome: Neuropathologic Observations Abstract THE SYNDROME of mirror movements is a congenital disorder of motor control in which voluntary movements initiated in one arm or leg are copied by the other. Usually, children with this syndrome have no other evidence of neurologic disease and improve as they grow older, although some degree of synkinesia may persist. Although mirror movements may be transmitted as an isolated autosomal dominant disorder, more often it is reported in association with congenital syndromes affecting other organ systems. The Klippel-Feil syndrome is characterized by a congenital failure of cervical segmentation resulting in apparent fusion of two or more cervical vertebrae.1 In 1932 Bauman2 described four children with these osseous anomalies who also had mirror movements. Four years later Avery and Rentfro3 published the only autopsy observations on a case with both disorders. The present report describes the autopsy findings in a second such case with certain References 1. Gunderson, C.H., et al: The Klippel-Feil Syndrome: Genetic and Clinical Reevaluation of Cervical Fusion , Medicine 46:491-512, 1967.Crossref 2. Bauman, G.I.: Absence of the Cervical Spine: Klippel-Feil Syndrome , JAMA 98:129-132, 1932.Crossref 3. Avery, L.N., and Rentfro, C.C.: The Klippel-Feil Syndrome: A Pathologic Report , Arch Neurol Psychiat 36:1068-1076, 1936.Crossref 4. Brock, S., and Krieger, H.P.: The Basis of Clinical Neurology , ed 4, Baltimore: Williams & Wilkins Co., 1963. 5. Fisher, C.M.: Symmetrical Mirror Movements and Left Ideomotor Apraxia , Trans Amer Neurol Assoc 88:214-216, 1963. 6. Regli, F.; Filippa, G.; and Wiesendanger, M.: Hereditary Mirror Movements , Arch Neurol 16:620-623, 1967.Crossref 7. Smith, C.K.: Mirror Movements , Amer J Dis Child 73:175-177, 1947. 8. Guttmann, E.; Maclay, W.S.; and Stokes, A.B.: Persistent Mirror Movements as a Heredofamilial Disorder , J Neurol Neurosurg Psychiat 2:13-24, 1939.Crossref 9. Meyer, B.C.: Report of a Family Exhibiting Hereditary Mirror Movements and Schizophrenia , J Nerv Ment Dis 96:138-152, 1942.Crossref 10. Erskine, C.A.: An Analysis of the Klippel-Feil Syndrome , Arch Path 41:269-281, 1946. 11. Spillane, J.D.; Pallis, C.; and Jones, A.M.: Developmental Abnormalities in the Region of the Foramen Magnum , Brain 80:11-48, 1957.Crossref 12. Willard, D.P.; and Nicholson, J.T.: The Klippel-Feil Syndrome , Ann Surg 99:561-567, 1934.Crossref 13. Baird, P.A.; Robinson, G.C.; and Buckler, W.St.J.: Klippel-Feil Syndrome: A Study of Mirror Movement Detected by Electromyography , Amer J Dis Child 113:546-551, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Mirror Movements in Patients With the Klippel-Feil Syndrome: Neuropathologic Observations

Archives of Neurology , Volume 18 (6) – Jun 1, 1968

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1968.00470360097009
Publisher site
See Article on Publisher Site

Abstract

Abstract THE SYNDROME of mirror movements is a congenital disorder of motor control in which voluntary movements initiated in one arm or leg are copied by the other. Usually, children with this syndrome have no other evidence of neurologic disease and improve as they grow older, although some degree of synkinesia may persist. Although mirror movements may be transmitted as an isolated autosomal dominant disorder, more often it is reported in association with congenital syndromes affecting other organ systems. The Klippel-Feil syndrome is characterized by a congenital failure of cervical segmentation resulting in apparent fusion of two or more cervical vertebrae.1 In 1932 Bauman2 described four children with these osseous anomalies who also had mirror movements. Four years later Avery and Rentfro3 published the only autopsy observations on a case with both disorders. The present report describes the autopsy findings in a second such case with certain References 1. Gunderson, C.H., et al: The Klippel-Feil Syndrome: Genetic and Clinical Reevaluation of Cervical Fusion , Medicine 46:491-512, 1967.Crossref 2. Bauman, G.I.: Absence of the Cervical Spine: Klippel-Feil Syndrome , JAMA 98:129-132, 1932.Crossref 3. Avery, L.N., and Rentfro, C.C.: The Klippel-Feil Syndrome: A Pathologic Report , Arch Neurol Psychiat 36:1068-1076, 1936.Crossref 4. Brock, S., and Krieger, H.P.: The Basis of Clinical Neurology , ed 4, Baltimore: Williams & Wilkins Co., 1963. 5. Fisher, C.M.: Symmetrical Mirror Movements and Left Ideomotor Apraxia , Trans Amer Neurol Assoc 88:214-216, 1963. 6. Regli, F.; Filippa, G.; and Wiesendanger, M.: Hereditary Mirror Movements , Arch Neurol 16:620-623, 1967.Crossref 7. Smith, C.K.: Mirror Movements , Amer J Dis Child 73:175-177, 1947. 8. Guttmann, E.; Maclay, W.S.; and Stokes, A.B.: Persistent Mirror Movements as a Heredofamilial Disorder , J Neurol Neurosurg Psychiat 2:13-24, 1939.Crossref 9. Meyer, B.C.: Report of a Family Exhibiting Hereditary Mirror Movements and Schizophrenia , J Nerv Ment Dis 96:138-152, 1942.Crossref 10. Erskine, C.A.: An Analysis of the Klippel-Feil Syndrome , Arch Path 41:269-281, 1946. 11. Spillane, J.D.; Pallis, C.; and Jones, A.M.: Developmental Abnormalities in the Region of the Foramen Magnum , Brain 80:11-48, 1957.Crossref 12. Willard, D.P.; and Nicholson, J.T.: The Klippel-Feil Syndrome , Ann Surg 99:561-567, 1934.Crossref 13. Baird, P.A.; Robinson, G.C.; and Buckler, W.St.J.: Klippel-Feil Syndrome: A Study of Mirror Movement Detected by Electromyography , Amer J Dis Child 113:546-551, 1967.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Jun 1, 1968

References