Abstract • A 67-year-old man presented with nephrotic syndrome and polymyalgia rheumatica. A renal biopsy revealed minimal-change nephropathy. The proteinuria and rheumatologic findings responded to prednisone therapy. The patient presented three months later with biliary tract obstruction secondary to pancreatic adenocarcinoma metastatic to the liver. The glomerulopathy and polymyalgia rheumatica in this case seemed to be components of the paraneoplastic syndrome. The response of both entities to prednisone therapy supports the hypothesis that they are caused by derangements in cell-mediated immunity. The fact that the tumor progressed despite resolution of the nephrosis and polymyalgia rheumatica suggests that cell-mediated immunity in general is altered by the tumor and not that the carcinoma liberates a factor that directly damages the kidney. (Arch Intern Med 1988;148:975-976) References 1. Hoyer JR: Idiopathic nephrotic syndrome with minimal glomerular changes. Contemp Issues Nephrol 1982;9:145-174. 2. Schroeter NJ, Rushing DA, Parker JP, et al: Minimal-change nephrotic syndrome associated with malignant mesothelioma. Arch Intern Med 1986;146:1834-1836.Crossref 3. Eagen JW, Lewis EJ: Glomerulopathies of neoplasia. Kidney Int 1977;11:297-306.Crossref 4. Shalhoub RJ: Pathogenesis of lipoid nephrosis: A disorder of T cell function. Lancet 1974;2:556-564.Crossref 5. Mallick NP: The pathogenesis of minimal change nephropathy. Clin Nephrol 1977;7:87-91. 6. Wu MJ, Moorthy AV: Suppressor cell function in patients with primary glomerular disease. Clin Immunol Immunopathol 1982;22:442-447.Crossref 7. Averbuch SD, Austin HA, Sherwin SA, et al: Acute interstitial nephritis with the nephrotic syndrome following recombinant leukocyte A interferon therapy for mycosis fungoides. N Engl J Med 1984;310:32-35.Crossref
Archives of Internal Medicine – American Medical Association
Published: Apr 1, 1988
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera