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Mineral Metabolism of the Healing Arterial Wall

Mineral Metabolism of the Healing Arterial Wall Abstract • The mineral metabolism of healing arterial walls was studied by measuring the accumulation of several radioisotopes at the site of vascular repair in rats. Each rat was subjected to a 1-cm full-thickness aortotomy and then immediately injected by tail vein with c 5 μCi of one of the following radioisotopes: chromic chloride Cr 51 or sodium chromate Cr 51; ferrous chloride Fe 59 or ferric chloride Fe 59; manganous chloride Mn 54; selenious acid Se 75; strontium chloride Sr 85; or zinc chloride Zn 65. At intervals of 1, 2, 4, 6, and 10 days after operation and injection, groups of four rats for each radioisotope were killed, aortas dissected, and the specific radioactivity of healing vascular tissue compared with that of adjacent normal artery. There were sharp and statistically significant differences in the preferential accumulation of the radioisotopes in healing compared with normal aorta. Zinc appeared to be the element most involved in vascular repair, followed by selenium and chromium. (Arch Surg 114:254-257, 1979) References 1. Savlov ED, Strain WH, Huegin F: Radiozinc studies in experimental wound healing . J Surg Res 2:209-212, 1962.Crossref 2. Stain WH, Huegin F, Lankau CA Jr, et al: Zinc-65 retention by aortic tissue of rats . Int J Appl Radiat Isot 12:231-237, 1964.Crossref 3. Pories WJ, Henzel JH, Rob CG, et al: Acceleration of wound healing in man with zinc sulphate given by mouth . Lancet 1:121-124, 1967.Crossref 4. Pories WH, Henzel JH, Rob CG, et al: Acceleration of healing with zinc sulfate . Ann Surg 165:432-436, 1967.Crossref 5. Mertz W: Chromium occurrence and function in biological systems . Physiol Rev 49:163-239, 1969. 6. National Research Council Committee on Biologic Effects of Atmospheric Pollutants: Chromium . Washington, DC, National Academy of Sciences, 1974. 7. Porter R, Fitzsimons DW (eds): Symposium on Iron Metabolism . Amsterdam, Elsevier/Excerpta Medica/North Holland, 1977. 8. National Research Council Committee on Biologic Effects of Atmospheric Pollutants: Manganese . Washington, DC, National Academy of Sciences, 1973. 9. National Research Council Committee on Biologic Effects of Atmospheric Pollutants: Selenium . Washington, DC, National Academy of Sciences, 1976. 10. Wing KR: Turnover of 65Zn and 85Sr in growing rats . Acta Radiol 14:1-24, 1975.Crossref 11. Strain WH, Rob CG, Pories WJ, et al: Activation analysis of normal and atherosclerotic aortas . Appl Spectrosc 23:121-124, 1969.Crossref 12. Pories WJ, Strain WH, Hsu JM, et al (eds): Clinical Applications of Zinc Metabolism . Springfield, Ill, Charles C Thomas Publisher, 1974. 13. Pories WJ, Mansour EG, Plecha FR, et al: Metabolic factors affecting zinc metabolism in the surgical patient , in Prasad AS (ed): Trace Elements in Human Health and Disease . New York, Academic Press Inc, 1976. 14. Zederfeldt B (ed): Symposium om Zink , Lund, Sweden, Tika, 1974. 15. Burch RE, Sullivan JF (eds): Symposium on trace elements . Med Clin North Am 60:655-852, 1976. 16. Hambidge KM, Nichols BL Jr: Zinc and Copper in Clinical Medicine . New York, SP Medical & Scientific Books, 1978. 17. Brewer GJ, Prasad AS, (eds): Zinc metabolism: Current aspects in health and disease . Prog Clin Biol Res 14:1-365, 1977. 18. Hankins DA, Riella MC, Scribner BH, et al: Whole blood trace element concentrations during total parenteral nutrition . Surgery 79:674-677, 1976. 19. Tucker SB, Schroeter AL, Brown PW Jr, et al: Acquired zinc deficiency: Cutaneous manifestations typical of acrodermatitis enteropathica . JAMA 235:2399-2402, 1976.Crossref 20. Kay RG, Tasman-Jones C, Pybus J, et al: A syndrome of acute zinc deficiency during total parenteral alimentation in man . Ann Surg 183:331-340, 1976.Crossref 21. Okada A, Takagi Y, Itakura T, et al: Skin lesions during intravenous hyperalimentation: Zinc deficiency . Surgery 80:629-635, 1976. 22. Weismann K, Hjorth N, Fischer A: Zinc depletion syndrome with acrodermatitis during long-term intravenous feeding . Clin Exp Dermatol 1:237-242, 1976.Crossref 23. Fischer JE: Hyperalimentation . Adv Surg 11:1-69, 1977. 24. Holm I: Parenteral nutrition in surgical and medical gastroenterology . Acta Chir Scand 143:297-305, 1977. 25. Jacobson S, Wester PO: Balance study of 20 trace elements during total parenteral nutrition in man . Br J Nutr 37:107-126, 1977.Crossref 26. Solomons NW, Layden TJ, Rosenberg IH, et al: Plasma trace metals during total parenteral alimentation . Gastroenterology 70:1022-1025, 1976. 27. Van Vloten WA, Bos LP: Skin lesions in acquired zinc deficiency due to parenteral nutrition . Dermatologica 156:175-183, 1978.Crossref 28. Tucker HF, Salmon WD: Parakeratosis or zinc deficiency disease in the pig . Proc Soc Exp Biol Med 88:613-616, 1955.Crossref 29. Strain WH, Hirsh FS, Michel B: Increased copper/zinc ratios in acrodermatitis enteropathica . Lancet 1:1196-1197, 1975.Crossref 30. Hodgson J: A Treatise on the Disease of Arteries and Veins, Containing the Pathology and Treatment of Aneurisms and Wound Arteries . London, Thomas Underwood, 1815. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1979.01370270028004
Publisher site
See Article on Publisher Site

Abstract

Abstract • The mineral metabolism of healing arterial walls was studied by measuring the accumulation of several radioisotopes at the site of vascular repair in rats. Each rat was subjected to a 1-cm full-thickness aortotomy and then immediately injected by tail vein with c 5 μCi of one of the following radioisotopes: chromic chloride Cr 51 or sodium chromate Cr 51; ferrous chloride Fe 59 or ferric chloride Fe 59; manganous chloride Mn 54; selenious acid Se 75; strontium chloride Sr 85; or zinc chloride Zn 65. At intervals of 1, 2, 4, 6, and 10 days after operation and injection, groups of four rats for each radioisotope were killed, aortas dissected, and the specific radioactivity of healing vascular tissue compared with that of adjacent normal artery. There were sharp and statistically significant differences in the preferential accumulation of the radioisotopes in healing compared with normal aorta. Zinc appeared to be the element most involved in vascular repair, followed by selenium and chromium. (Arch Surg 114:254-257, 1979) References 1. Savlov ED, Strain WH, Huegin F: Radiozinc studies in experimental wound healing . J Surg Res 2:209-212, 1962.Crossref 2. Stain WH, Huegin F, Lankau CA Jr, et al: Zinc-65 retention by aortic tissue of rats . Int J Appl Radiat Isot 12:231-237, 1964.Crossref 3. Pories WJ, Henzel JH, Rob CG, et al: Acceleration of wound healing in man with zinc sulphate given by mouth . Lancet 1:121-124, 1967.Crossref 4. Pories WH, Henzel JH, Rob CG, et al: Acceleration of healing with zinc sulfate . Ann Surg 165:432-436, 1967.Crossref 5. Mertz W: Chromium occurrence and function in biological systems . Physiol Rev 49:163-239, 1969. 6. National Research Council Committee on Biologic Effects of Atmospheric Pollutants: Chromium . Washington, DC, National Academy of Sciences, 1974. 7. Porter R, Fitzsimons DW (eds): Symposium on Iron Metabolism . Amsterdam, Elsevier/Excerpta Medica/North Holland, 1977. 8. National Research Council Committee on Biologic Effects of Atmospheric Pollutants: Manganese . Washington, DC, National Academy of Sciences, 1973. 9. National Research Council Committee on Biologic Effects of Atmospheric Pollutants: Selenium . Washington, DC, National Academy of Sciences, 1976. 10. Wing KR: Turnover of 65Zn and 85Sr in growing rats . Acta Radiol 14:1-24, 1975.Crossref 11. Strain WH, Rob CG, Pories WJ, et al: Activation analysis of normal and atherosclerotic aortas . Appl Spectrosc 23:121-124, 1969.Crossref 12. Pories WJ, Strain WH, Hsu JM, et al (eds): Clinical Applications of Zinc Metabolism . Springfield, Ill, Charles C Thomas Publisher, 1974. 13. Pories WJ, Mansour EG, Plecha FR, et al: Metabolic factors affecting zinc metabolism in the surgical patient , in Prasad AS (ed): Trace Elements in Human Health and Disease . New York, Academic Press Inc, 1976. 14. Zederfeldt B (ed): Symposium om Zink , Lund, Sweden, Tika, 1974. 15. Burch RE, Sullivan JF (eds): Symposium on trace elements . Med Clin North Am 60:655-852, 1976. 16. Hambidge KM, Nichols BL Jr: Zinc and Copper in Clinical Medicine . New York, SP Medical & Scientific Books, 1978. 17. Brewer GJ, Prasad AS, (eds): Zinc metabolism: Current aspects in health and disease . Prog Clin Biol Res 14:1-365, 1977. 18. Hankins DA, Riella MC, Scribner BH, et al: Whole blood trace element concentrations during total parenteral nutrition . Surgery 79:674-677, 1976. 19. Tucker SB, Schroeter AL, Brown PW Jr, et al: Acquired zinc deficiency: Cutaneous manifestations typical of acrodermatitis enteropathica . JAMA 235:2399-2402, 1976.Crossref 20. Kay RG, Tasman-Jones C, Pybus J, et al: A syndrome of acute zinc deficiency during total parenteral alimentation in man . Ann Surg 183:331-340, 1976.Crossref 21. Okada A, Takagi Y, Itakura T, et al: Skin lesions during intravenous hyperalimentation: Zinc deficiency . Surgery 80:629-635, 1976. 22. Weismann K, Hjorth N, Fischer A: Zinc depletion syndrome with acrodermatitis during long-term intravenous feeding . Clin Exp Dermatol 1:237-242, 1976.Crossref 23. Fischer JE: Hyperalimentation . Adv Surg 11:1-69, 1977. 24. Holm I: Parenteral nutrition in surgical and medical gastroenterology . Acta Chir Scand 143:297-305, 1977. 25. Jacobson S, Wester PO: Balance study of 20 trace elements during total parenteral nutrition in man . Br J Nutr 37:107-126, 1977.Crossref 26. Solomons NW, Layden TJ, Rosenberg IH, et al: Plasma trace metals during total parenteral alimentation . Gastroenterology 70:1022-1025, 1976. 27. Van Vloten WA, Bos LP: Skin lesions in acquired zinc deficiency due to parenteral nutrition . Dermatologica 156:175-183, 1978.Crossref 28. Tucker HF, Salmon WD: Parakeratosis or zinc deficiency disease in the pig . Proc Soc Exp Biol Med 88:613-616, 1955.Crossref 29. Strain WH, Hirsh FS, Michel B: Increased copper/zinc ratios in acrodermatitis enteropathica . Lancet 1:1196-1197, 1975.Crossref 30. Hodgson J: A Treatise on the Disease of Arteries and Veins, Containing the Pathology and Treatment of Aneurisms and Wound Arteries . London, Thomas Underwood, 1815.

Journal

Archives of SurgeryAmerican Medical Association

Published: Mar 1, 1979

References

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