Abstract • The mineral metabolism of healing arterial walls was studied by measuring the accumulation of several radioisotopes at the site of vascular repair in rats. Each rat was subjected to a 1-cm full-thickness aortotomy and then immediately injected by tail vein with c 5 μCi of one of the following radioisotopes: chromic chloride Cr 51 or sodium chromate Cr 51; ferrous chloride Fe 59 or ferric chloride Fe 59; manganous chloride Mn 54; selenious acid Se 75; strontium chloride Sr 85; or zinc chloride Zn 65. At intervals of 1, 2, 4, 6, and 10 days after operation and injection, groups of four rats for each radioisotope were killed, aortas dissected, and the specific radioactivity of healing vascular tissue compared with that of adjacent normal artery. There were sharp and statistically significant differences in the preferential accumulation of the radioisotopes in healing compared with normal aorta. Zinc appeared to be the element most involved in vascular repair, followed by selenium and chromium. (Arch Surg 114:254-257, 1979) References 1. Savlov ED, Strain WH, Huegin F: Radiozinc studies in experimental wound healing . J Surg Res 2:209-212, 1962.Crossref 2. Stain WH, Huegin F, Lankau CA Jr, et al: Zinc-65 retention by aortic tissue of rats . Int J Appl Radiat Isot 12:231-237, 1964.Crossref 3. Pories WJ, Henzel JH, Rob CG, et al: Acceleration of wound healing in man with zinc sulphate given by mouth . Lancet 1:121-124, 1967.Crossref 4. Pories WH, Henzel JH, Rob CG, et al: Acceleration of healing with zinc sulfate . Ann Surg 165:432-436, 1967.Crossref 5. Mertz W: Chromium occurrence and function in biological systems . Physiol Rev 49:163-239, 1969. 6. National Research Council Committee on Biologic Effects of Atmospheric Pollutants: Chromium . Washington, DC, National Academy of Sciences, 1974. 7. Porter R, Fitzsimons DW (eds): Symposium on Iron Metabolism . 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Okada A, Takagi Y, Itakura T, et al: Skin lesions during intravenous hyperalimentation: Zinc deficiency . Surgery 80:629-635, 1976. 22. Weismann K, Hjorth N, Fischer A: Zinc depletion syndrome with acrodermatitis during long-term intravenous feeding . Clin Exp Dermatol 1:237-242, 1976.Crossref 23. Fischer JE: Hyperalimentation . Adv Surg 11:1-69, 1977. 24. Holm I: Parenteral nutrition in surgical and medical gastroenterology . Acta Chir Scand 143:297-305, 1977. 25. Jacobson S, Wester PO: Balance study of 20 trace elements during total parenteral nutrition in man . Br J Nutr 37:107-126, 1977.Crossref 26. Solomons NW, Layden TJ, Rosenberg IH, et al: Plasma trace metals during total parenteral alimentation . Gastroenterology 70:1022-1025, 1976. 27. Van Vloten WA, Bos LP: Skin lesions in acquired zinc deficiency due to parenteral nutrition . Dermatologica 156:175-183, 1978.Crossref 28. Tucker HF, Salmon WD: Parakeratosis or zinc deficiency disease in the pig . Proc Soc Exp Biol Med 88:613-616, 1955.Crossref 29. Strain WH, Hirsh FS, Michel B: Increased copper/zinc ratios in acrodermatitis enteropathica . Lancet 1:1196-1197, 1975.Crossref 30. Hodgson J: A Treatise on the Disease of Arteries and Veins, Containing the Pathology and Treatment of Aneurisms and Wound Arteries . London, Thomas Underwood, 1815.
Archives of Surgery – American Medical Association
Published: Mar 1, 1979
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