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Mild Neonatal Toxoplasmosis: Case Report with a Four-Year Serologic and Dermal Sensitivity Study

Mild Neonatal Toxoplasmosis: Case Report with a Four-Year Serologic and Dermal Sensitivity Study Abstract Congenital toxoplasmosis is a generalized infectious disease in humans and animals caused by the protozoan, Toxoplasma gondii, which is transmitted transplacentally from the mother to the fetus. Signs of the disease may become apparent in utero or within a few days, weeks, or months after birth. That human congenital Toxoplasma infections may be mild or asymptomatic as well as severe and fatal is not well known. Most of the congenital toxoplasmosis cases reported in the literature have been severe or fatal infections either with clinical signs of central nervous system damage, such as chorioretinitis, psychomotor retardation or disturbances, cerebral calcifications, and hydro- or microcephaly, or visceral manifestations of jaundice and hepatosplenomegaly or any combination of the above.1 A definite diagnosis can be established by adequate serologic tests2,3 or by demonstrating the parasite in body fluids or tissues. The following case of congenital toxoplasmosis is considered of value because References 1. Sabin, A. B.; Eichenwald, H.; Feldman, H. A., and Jacobs, L.: Present Status of Clinical Manifestations of Toxoplasmosis in Man: Indications and Provisions for Routine Serologic Diagnosis , J. A. M. A. 150:1063-1069 ( (Nov. 15) ) 1952.Crossref 2. Sabin, A. B., and Feldman, H. A.: Dyes as Microchemical Indicators of a New Immunity Phenomenon Affecting a Protozoan Parasite (Toxoplasma) , Science 108:660-663 ( (Dec. 10) ) 1948.Crossref 3. Sabin, A. B.: Complement Fixation Test in Toxoplasmosis and Persistence of Antibody in Human Beings , Pediatrics 4:443-453 ( (Oct.) ) 1949. 4. Eichenwald, H.: Personal Communication to the author. 5. Eichenwald, H.: Experimental Toxoplasmosis: Effect of Sulfadiazine and Antiserum on Congenital Toxoplasmosis in Mice , Proc. Soc. Exper. Biol. & Med. 71:45-49 ( (May) ) 1949. 6. Frenkel, J. K.: Dermal Hypersensitivity to Toxoplasma Antigens (Toxoplasmins) , Proc. Soc. Exper. Biol. & Med. 68:634-639 ( (July) -Aug.) 1948. 7. Feldman, H. A.: The Clinical Manifestations and Laboratory Diagnosis of Toxoplasmosis , Am. J. Trop. Med. 2:420-428 ( (May) ) 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Mild Neonatal Toxoplasmosis: Case Report with a Four-Year Serologic and Dermal Sensitivity Study

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1957.02060040565012
Publisher site
See Article on Publisher Site

Abstract

Abstract Congenital toxoplasmosis is a generalized infectious disease in humans and animals caused by the protozoan, Toxoplasma gondii, which is transmitted transplacentally from the mother to the fetus. Signs of the disease may become apparent in utero or within a few days, weeks, or months after birth. That human congenital Toxoplasma infections may be mild or asymptomatic as well as severe and fatal is not well known. Most of the congenital toxoplasmosis cases reported in the literature have been severe or fatal infections either with clinical signs of central nervous system damage, such as chorioretinitis, psychomotor retardation or disturbances, cerebral calcifications, and hydro- or microcephaly, or visceral manifestations of jaundice and hepatosplenomegaly or any combination of the above.1 A definite diagnosis can be established by adequate serologic tests2,3 or by demonstrating the parasite in body fluids or tissues. The following case of congenital toxoplasmosis is considered of value because References 1. Sabin, A. B.; Eichenwald, H.; Feldman, H. A., and Jacobs, L.: Present Status of Clinical Manifestations of Toxoplasmosis in Man: Indications and Provisions for Routine Serologic Diagnosis , J. A. M. A. 150:1063-1069 ( (Nov. 15) ) 1952.Crossref 2. Sabin, A. B., and Feldman, H. A.: Dyes as Microchemical Indicators of a New Immunity Phenomenon Affecting a Protozoan Parasite (Toxoplasma) , Science 108:660-663 ( (Dec. 10) ) 1948.Crossref 3. Sabin, A. B.: Complement Fixation Test in Toxoplasmosis and Persistence of Antibody in Human Beings , Pediatrics 4:443-453 ( (Oct.) ) 1949. 4. Eichenwald, H.: Personal Communication to the author. 5. Eichenwald, H.: Experimental Toxoplasmosis: Effect of Sulfadiazine and Antiserum on Congenital Toxoplasmosis in Mice , Proc. Soc. Exper. Biol. & Med. 71:45-49 ( (May) ) 1949. 6. Frenkel, J. K.: Dermal Hypersensitivity to Toxoplasma Antigens (Toxoplasmins) , Proc. Soc. Exper. Biol. & Med. 68:634-639 ( (July) -Aug.) 1948. 7. Feldman, H. A.: The Clinical Manifestations and Laboratory Diagnosis of Toxoplasmosis , Am. J. Trop. Med. 2:420-428 ( (May) ) 1953.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1957

References