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Middle and Inner Ear Abnormalities: 13-15 (D1) Trisomy

Middle and Inner Ear Abnormalities: 13-15 (D1) Trisomy Abstract Temporal bone findings from the study of a patient afflicted with trisomy 13-15 syndrome included multiple anomalies of the middle ear structures derived from the second branchial arch and abnormalties of the otic capsule. A shortened but otherwise well-formed Corti's organ was situated in a distorted and incompletely developed bony cochlea. Cochlear hair cells were sufficiently well preserved to allow mapping. The complement of hair cells present in these temporal bones contrasts with some previously reported findings. References 1. Patau K, Smith DW, Therman E, et al: Multiple congenital anomaly caused by an extra autosome . Lancet 1:790-793, 1960.Crossref 2. Mottet NK, Jensen H: Anomalous embryonic development associated with trisomy 13-15 . Amer J Clin Path 43: 334-341, 1965. 3. Kos AO, Schunknecht HF, Singer JR: Temporal bone studies in 13-15 and 18 trisomy syndromes . Arch Otolaryng 83:439-445, 1966.Crossref 4. Keleman G, Hooft C, Ckluyskens R: The inner ear in autosomal trisomy . Pract Otorhinolaryng 30:251-258, 1968. 5. Maniglia AJ, Wolff D, Herques AJ: Congenital deafness in 13-15 trisomy syndrome . Arch Otolaryng 92:181-188, 1970.Crossref 6. Schuknecht HF; Pathology and sensorineural deafness of genetic origin , in McConnell F, Ward PH (eds): Deafness in Children . Nashville, Tenn, Vanderbilt University Press, 1967, chap 7. 7. Fernandez C: Postomortem changes and artifacts in human temporal bone . Laryngoscope 68:1586-1614, 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Middle and Inner Ear Abnormalities: 13-15 (D1) Trisomy

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Publisher
American Medical Association
Copyright
Copyright © 1971 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1971.00770060917013
Publisher site
See Article on Publisher Site

Abstract

Abstract Temporal bone findings from the study of a patient afflicted with trisomy 13-15 syndrome included multiple anomalies of the middle ear structures derived from the second branchial arch and abnormalties of the otic capsule. A shortened but otherwise well-formed Corti's organ was situated in a distorted and incompletely developed bony cochlea. Cochlear hair cells were sufficiently well preserved to allow mapping. The complement of hair cells present in these temporal bones contrasts with some previously reported findings. References 1. Patau K, Smith DW, Therman E, et al: Multiple congenital anomaly caused by an extra autosome . Lancet 1:790-793, 1960.Crossref 2. Mottet NK, Jensen H: Anomalous embryonic development associated with trisomy 13-15 . Amer J Clin Path 43: 334-341, 1965. 3. Kos AO, Schunknecht HF, Singer JR: Temporal bone studies in 13-15 and 18 trisomy syndromes . Arch Otolaryng 83:439-445, 1966.Crossref 4. Keleman G, Hooft C, Ckluyskens R: The inner ear in autosomal trisomy . Pract Otorhinolaryng 30:251-258, 1968. 5. Maniglia AJ, Wolff D, Herques AJ: Congenital deafness in 13-15 trisomy syndrome . Arch Otolaryng 92:181-188, 1970.Crossref 6. Schuknecht HF; Pathology and sensorineural deafness of genetic origin , in McConnell F, Ward PH (eds): Deafness in Children . Nashville, Tenn, Vanderbilt University Press, 1967, chap 7. 7. Fernandez C: Postomortem changes and artifacts in human temporal bone . Laryngoscope 68:1586-1614, 1958.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Jun 1, 1971

References