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Methysergide in the Treatment of Narcolepsy

Methysergide in the Treatment of Narcolepsy Abstract Five patients with narcolepsy (four with the allied symptom of cataplexy) were treated with the serotonin antagonist methysergide. All patients had as good control of their sleep attacks while on methysergide therapy as on a control period of dextroamphetamine therapy. The cataplexy was less well controlled by methysergide than by dextroamphetamine, but improved when compared to a period without medication. Two patients developed severe calf claudication while on methysergide. References 1. Adie WJ: Idiopathic narcolepsy: A disease sui generis with remarks on the generation of sleep . Brain 49:257-306, 1926.Crossref 2. Dement W, Kleitman N: Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming . Electroencephalogr Clin Neurophysiol 9:673-690, 1957.Crossref 3. Rechtschaffen A, Wolpert EA, Dement W, et al: Nocturnal sleep of narcoleptics . Electroencephalogr Clin Neurophysiol 15:599-609, 1963.Crossref 4. Hishikawa Y, Kaneko Z: Electroencephalographic study on narcolepsy . Electroencephalogr Clin Neurophysiol 18:249-259, 1965.Crossref 5. Dement W, Rechtschaffen A, Gulevich G: The nature of the narcoleptic sleep attack . Neurology 16:18-33, 1966.Crossref 6. Hishikawa Y, Hisahige N, Tachibana M, et al: The nature of sleep attack and other symptoms of narcolepsy . Electroencephalogr Clin Neurophysiol 24:1-10, 1968.Crossref 7. Roth B, Bruhova S, Lehovsky M: REM sleep and NREM sleep in narcolepsy and hypersomnia . Electroencephalogr Clin Neurophysiol 26:176-182, 1969.Crossref 8. Jouvet M: Neurophysiology of the states of sleep . Physiol Rev 47:117-177, 1967. 9. Jouvet M: Biogenic amines and state of sleep . Science 163:32-41, 1969.Crossref 10. Koella WP, Czicman JS: Mechanism of the EEG synchronization action of serotonin . Am J Physiol 211:926-934, 1966. 11. Koella WP: Biochemistry of sleep , in Chase MH (ed): The Sleeping Brain Los Angeles, UCLA Brain Information Center, 1972, pp 145-189. 12. Broughton R: Neurology and sleep research . Can Psychiatr Assoc J 16:283-293, 1971. 13. Broughton R: Sleep and clinical pathological states , in Chase M (ed): The Sleeping Brain . Los Angeles, UCLA Brain Information Center, 1972, pp 363-369. 14. Goodman LS, Gilman A: The Pharmacological Basis of Therapeutics , ed 3. New York, Macmillan Co, 1956, p 652. 15. Rechtschaffen A, Kales A (eds): A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects . Los Angeles, UCLA Brain Information Service, 1973. 16. Guilleminault C, Carskadon M, Dement WC: On the treatment of rapid eye movement narcolepsy . Arch Neurol 30:90-93, 1974.Crossref 17. Parks JD, Fenton GW: Levo (-) amphetamine and dextro ( + ) amphetamine in the treatment of narcolepsy . J Neurol Neurosurg Psychiatr 36:1076-1081, 1973.Crossref 18. Doyle JB, Daniels LE: Symptomatic treatment for narcolepsy . JAMA 97:1370-1372, 1931.Crossref 19. Gunne L, Lidvall H, Widen C: Preliminary clinical trial with L-dopa in narcolepsy . Psychopharmacologia 19:204-207, 1971.Crossref 20. Guilleminault C, Castiagne P, Cathala HP: Observation on the effectiveness of amantadine, L-dopa plus dopadecarboxylase inhibitor, and dopadecarboxylase inhibitor in the treatment of narcolepsy , in Chase M, Western WPL (eds): Sleep Research , Los Angeles, UCLA Brain Research Institute, 1972, vol 1, p 130. 21. Graham JR, Suby HI, LeCompte PR, et al: Fibrotic disorders associated with methysergide therapy for headache . N Engl J Med 274:359-368, 1966.Crossref 22. Graham JR: Cardiac and pulmonary fibrosis during methysergide therapy for headache . Am J Med Sci 254:1-12, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Methysergide in the Treatment of Narcolepsy

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1975.00490460081012
Publisher site
See Article on Publisher Site

Abstract

Abstract Five patients with narcolepsy (four with the allied symptom of cataplexy) were treated with the serotonin antagonist methysergide. All patients had as good control of their sleep attacks while on methysergide therapy as on a control period of dextroamphetamine therapy. The cataplexy was less well controlled by methysergide than by dextroamphetamine, but improved when compared to a period without medication. Two patients developed severe calf claudication while on methysergide. References 1. Adie WJ: Idiopathic narcolepsy: A disease sui generis with remarks on the generation of sleep . Brain 49:257-306, 1926.Crossref 2. Dement W, Kleitman N: Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming . Electroencephalogr Clin Neurophysiol 9:673-690, 1957.Crossref 3. Rechtschaffen A, Wolpert EA, Dement W, et al: Nocturnal sleep of narcoleptics . Electroencephalogr Clin Neurophysiol 15:599-609, 1963.Crossref 4. Hishikawa Y, Kaneko Z: Electroencephalographic study on narcolepsy . Electroencephalogr Clin Neurophysiol 18:249-259, 1965.Crossref 5. Dement W, Rechtschaffen A, Gulevich G: The nature of the narcoleptic sleep attack . Neurology 16:18-33, 1966.Crossref 6. Hishikawa Y, Hisahige N, Tachibana M, et al: The nature of sleep attack and other symptoms of narcolepsy . Electroencephalogr Clin Neurophysiol 24:1-10, 1968.Crossref 7. Roth B, Bruhova S, Lehovsky M: REM sleep and NREM sleep in narcolepsy and hypersomnia . Electroencephalogr Clin Neurophysiol 26:176-182, 1969.Crossref 8. Jouvet M: Neurophysiology of the states of sleep . Physiol Rev 47:117-177, 1967. 9. Jouvet M: Biogenic amines and state of sleep . Science 163:32-41, 1969.Crossref 10. Koella WP, Czicman JS: Mechanism of the EEG synchronization action of serotonin . Am J Physiol 211:926-934, 1966. 11. Koella WP: Biochemistry of sleep , in Chase MH (ed): The Sleeping Brain Los Angeles, UCLA Brain Information Center, 1972, pp 145-189. 12. Broughton R: Neurology and sleep research . Can Psychiatr Assoc J 16:283-293, 1971. 13. Broughton R: Sleep and clinical pathological states , in Chase M (ed): The Sleeping Brain . Los Angeles, UCLA Brain Information Center, 1972, pp 363-369. 14. Goodman LS, Gilman A: The Pharmacological Basis of Therapeutics , ed 3. New York, Macmillan Co, 1956, p 652. 15. Rechtschaffen A, Kales A (eds): A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects . Los Angeles, UCLA Brain Information Service, 1973. 16. Guilleminault C, Carskadon M, Dement WC: On the treatment of rapid eye movement narcolepsy . Arch Neurol 30:90-93, 1974.Crossref 17. Parks JD, Fenton GW: Levo (-) amphetamine and dextro ( + ) amphetamine in the treatment of narcolepsy . J Neurol Neurosurg Psychiatr 36:1076-1081, 1973.Crossref 18. Doyle JB, Daniels LE: Symptomatic treatment for narcolepsy . JAMA 97:1370-1372, 1931.Crossref 19. Gunne L, Lidvall H, Widen C: Preliminary clinical trial with L-dopa in narcolepsy . Psychopharmacologia 19:204-207, 1971.Crossref 20. Guilleminault C, Castiagne P, Cathala HP: Observation on the effectiveness of amantadine, L-dopa plus dopadecarboxylase inhibitor, and dopadecarboxylase inhibitor in the treatment of narcolepsy , in Chase M, Western WPL (eds): Sleep Research , Los Angeles, UCLA Brain Research Institute, 1972, vol 1, p 130. 21. Graham JR, Suby HI, LeCompte PR, et al: Fibrotic disorders associated with methysergide therapy for headache . N Engl J Med 274:359-368, 1966.Crossref 22. Graham JR: Cardiac and pulmonary fibrosis during methysergide therapy for headache . Am J Med Sci 254:1-12, 1967.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Apr 1, 1975

References