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Methyldopa for Treatment of Hypertension

Methyldopa for Treatment of Hypertension Methyldopa is an enzyme inhibitor and an effective antihypertensive agent in man. In a study of 33 hypertensive patients, mean blood pressure levels were reduced more than 10% for the sitting position in 61%, and for the standing position in 71%. There were indications of liver damage in seven patients, probable drug fever in one, fluid retention in four, and aggravation of angina pectoris in two. The best indication for the use of methyldopa appeared to be renal insufficiency in hypertensive patients. The authors hesitate to advocate other than investigational use of this drug until the significance of its effects on the heart and liver are more clearly established. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Methyldopa for Treatment of Hypertension

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1963.03700210050008
Publisher site
See Article on Publisher Site

Abstract

Methyldopa is an enzyme inhibitor and an effective antihypertensive agent in man. In a study of 33 hypertensive patients, mean blood pressure levels were reduced more than 10% for the sitting position in 61%, and for the standing position in 71%. There were indications of liver damage in seven patients, probable drug fever in one, fluid retention in four, and aggravation of angina pectoris in two. The best indication for the use of methyldopa appeared to be renal insufficiency in hypertensive patients. The authors hesitate to advocate other than investigational use of this drug until the significance of its effects on the heart and liver are more clearly established.

Journal

JAMAAmerican Medical Association

Published: May 25, 1963

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