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Methoxsalen and Multiple Basal Cell Carcinomas

Methoxsalen and Multiple Basal Cell Carcinomas Abstract To the Editor.— Serious adverse effects caused by treatment of vitiligo with methoxsalen and ultraviolet (UV) radiation have not, to our knowledge, been reported. However, skin cancer and ocular damage may develop in animals during treatment with methoxsalen and UV radiation.1,2Photochemotherapy with methoxsalen and high-intensity, long-wave UV radiation (black light) has recently been introduced as a treatment for psoriasis.3 In contrast to vitiligo patients, a majority of patients with psoriasis have been previously treated with potential carcinogens such as arsenic and x-ray or UV radiation.We observed that treatment with methoxsalen and sunlight was followed by a development of multiple basal cell carcinomes in a patient who previously had been treated with arsenic for vitiligo. Report of a Case.— A 41-year-old woman who had had vitiligo since about 14 years of age was examined in our department for the first time in 1971. The patient had hitherto References 1. Griffin AC, Hakim RE, Knox J: The wave length effect upon erythemal and carcinogenic response in psoralen-treated mice . J Invest Dermatol 31:289-294, 1958.Crossref 2. O'Neal MA, Griffin AC: The effect of oxypsoralen upon ultraviolet carcinogenesis in albino mice . Cancer Res 17:911-916, 1957. 3. Parrish JA, Fitzpatrick TB, Tanenbaum L, et al: Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light . N Engl J Med 291:1207-1211, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Methoxsalen and Multiple Basal Cell Carcinomas

Archives of Dermatology , Volume 112 (11) – Nov 1, 1976

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630350079027
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Serious adverse effects caused by treatment of vitiligo with methoxsalen and ultraviolet (UV) radiation have not, to our knowledge, been reported. However, skin cancer and ocular damage may develop in animals during treatment with methoxsalen and UV radiation.1,2Photochemotherapy with methoxsalen and high-intensity, long-wave UV radiation (black light) has recently been introduced as a treatment for psoriasis.3 In contrast to vitiligo patients, a majority of patients with psoriasis have been previously treated with potential carcinogens such as arsenic and x-ray or UV radiation.We observed that treatment with methoxsalen and sunlight was followed by a development of multiple basal cell carcinomes in a patient who previously had been treated with arsenic for vitiligo. Report of a Case.— A 41-year-old woman who had had vitiligo since about 14 years of age was examined in our department for the first time in 1971. The patient had hitherto References 1. Griffin AC, Hakim RE, Knox J: The wave length effect upon erythemal and carcinogenic response in psoralen-treated mice . J Invest Dermatol 31:289-294, 1958.Crossref 2. O'Neal MA, Griffin AC: The effect of oxypsoralen upon ultraviolet carcinogenesis in albino mice . Cancer Res 17:911-916, 1957. 3. Parrish JA, Fitzpatrick TB, Tanenbaum L, et al: Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light . N Engl J Med 291:1207-1211, 1974.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1976

References