Abstract Twenty-four of 36 patients with pemphigus vulgaris were treated with methotrexate alone or in various combinations with prednisone, All 24 patients were living and in good condition when reexamined on Sept 1, 1971. Eight patients were free of lesions, whereas 16 patients still had some lesions, predominantly in the mouth. It seems that in patients who receive a regimen of methotrexate in the early phase of the disease the need for, or length of, highdosage treatment with prednisone is reduced. In patients with advanced disease in whom the disease has been brought under control by high-dosage treatment with prednisone, smaller maintenance doses of prednisone usually are possible when methotrexate is also administered. Methotrexate therapy in weekly doses of 20 to 50 mg caused no serious complications. Oral lesions respond much less readily than cutaneous lesions to methotrexate. References 1. Lever WF, White H: Treatment of pemphigus with corticosteroids . Arch Derm 87:12-26, 1963.Crossref 2. Ryan JG: Pemphigus . Arch Derm 104:14-20, 1971.Crossref 3. Lever WF, Goldberg HS: Treatment of pemphigus with methotrexate . Arch Derm 100:70-78, 1969.Crossref 4. Lever WF, Hashimoto K: The etiology and treatment of pemphigus and pemphigoid . J Invest Derm 53:373-389, 1969.Crossref 5. Chorzelski TP, von Weiss JF, Lever WF: Clinical significance of autoantibodies in pemphigus . Arch Derm 93:570-576, 1966.Crossref
Archives of Dermatology – American Medical Association
Published: Oct 1, 1972
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