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Method for Comparing Percutaneous Absorption of Steroids

Method for Comparing Percutaneous Absorption of Steroids Abstract A simple method for assessing the percutaneous absorption of steroid preparations is suggested. Using vasoconstriction as an index of absorption, occlusion of the skin surface with Saran Wrap results in a 100-fold difference in absorption over simple topical application. References 1. Supplied by Merck Sharp Dohme Research Laboratory, Pa. 2. Supplied by E. R. Squibb Sons, N.Y. 3. Supplied by Syntex Laboratories Inc., N.Y. 4. Garb, J.: Nevus Verrucosus Unilateralis Cured with Podophyllin Ointment , Arch. Derm. 81: 606, 1960.Crossref 5. Scholtz, J. R.: Topical Therapy of Psoriasis with Fluocinolone Acetonide , Arch. Derm. 84:1029, 1961.Crossref 6. Sulzberger, M. B., and Witten, V. H.: Thin Pliable Plastic Films in Topical Dermatological Therapy , Arch. Derm. 84:1027, 1961.Crossref 7. Ashton, N., and Cook, C.: In Vivo Observations of the Effects of Cortisone upon the Blood Vessels in Rabbit Ear Chambers , Brit. J. Exp. Path. 33:445, 1952. 8. Hollander, J. L.; Stoner, E. K.; Brown, E. M., Jr., and De Moor, P.: The Use of Intra-Articular Temperature Measurement in the Evaluation of Antiarthritic Agents , Ann. Rheum. Dis. 9:401, 1950. 9. Rothman, S.: Physiology and Biochemistry of the Skin , Chicago, University of Chicago Press, 1954, p. 52. 10. Cronin, E., and Stoughton, R. B., in Brit. J. Derm., to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Method for Comparing Percutaneous Absorption of Steroids

Archives of Dermatology , Volume 86 (5) – Nov 1, 1962

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1962.01590110044005
Publisher site
See Article on Publisher Site

Abstract

Abstract A simple method for assessing the percutaneous absorption of steroid preparations is suggested. Using vasoconstriction as an index of absorption, occlusion of the skin surface with Saran Wrap results in a 100-fold difference in absorption over simple topical application. References 1. Supplied by Merck Sharp Dohme Research Laboratory, Pa. 2. Supplied by E. R. Squibb Sons, N.Y. 3. Supplied by Syntex Laboratories Inc., N.Y. 4. Garb, J.: Nevus Verrucosus Unilateralis Cured with Podophyllin Ointment , Arch. Derm. 81: 606, 1960.Crossref 5. Scholtz, J. R.: Topical Therapy of Psoriasis with Fluocinolone Acetonide , Arch. Derm. 84:1029, 1961.Crossref 6. Sulzberger, M. B., and Witten, V. H.: Thin Pliable Plastic Films in Topical Dermatological Therapy , Arch. Derm. 84:1027, 1961.Crossref 7. Ashton, N., and Cook, C.: In Vivo Observations of the Effects of Cortisone upon the Blood Vessels in Rabbit Ear Chambers , Brit. J. Exp. Path. 33:445, 1952. 8. Hollander, J. L.; Stoner, E. K.; Brown, E. M., Jr., and De Moor, P.: The Use of Intra-Articular Temperature Measurement in the Evaluation of Antiarthritic Agents , Ann. Rheum. Dis. 9:401, 1950. 9. Rothman, S.: Physiology and Biochemistry of the Skin , Chicago, University of Chicago Press, 1954, p. 52. 10. Cronin, E., and Stoughton, R. B., in Brit. J. Derm., to be published.

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1962

References