Abstract A simple method for assessing the percutaneous absorption of steroid preparations is suggested. Using vasoconstriction as an index of absorption, occlusion of the skin surface with Saran Wrap results in a 100-fold difference in absorption over simple topical application. References 1. Supplied by Merck Sharp Dohme Research Laboratory, Pa. 2. Supplied by E. R. Squibb Sons, N.Y. 3. Supplied by Syntex Laboratories Inc., N.Y. 4. Garb, J.: Nevus Verrucosus Unilateralis Cured with Podophyllin Ointment , Arch. Derm. 81: 606, 1960.Crossref 5. Scholtz, J. R.: Topical Therapy of Psoriasis with Fluocinolone Acetonide , Arch. Derm. 84:1029, 1961.Crossref 6. Sulzberger, M. B., and Witten, V. H.: Thin Pliable Plastic Films in Topical Dermatological Therapy , Arch. Derm. 84:1027, 1961.Crossref 7. Ashton, N., and Cook, C.: In Vivo Observations of the Effects of Cortisone upon the Blood Vessels in Rabbit Ear Chambers , Brit. J. Exp. Path. 33:445, 1952. 8. Hollander, J. L.; Stoner, E. K.; Brown, E. M., Jr., and De Moor, P.: The Use of Intra-Articular Temperature Measurement in the Evaluation of Antiarthritic Agents , Ann. Rheum. Dis. 9:401, 1950. 9. Rothman, S.: Physiology and Biochemistry of the Skin , Chicago, University of Chicago Press, 1954, p. 52. 10. Cronin, E., and Stoughton, R. B., in Brit. J. Derm., to be published.
Archives of Dermatology – American Medical Association
Published: Nov 1, 1962