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METASTASIS OF NEOPLASMS TO THE CENTRAL NERVOUS SYSTEM AND MENINGES

METASTASIS OF NEOPLASMS TO THE CENTRAL NERVOUS SYSTEM AND MENINGES Abstract THERE ARE few reports of metastatic neoplasms in the central nervous system and meninges based on study of a large series of complete necropsies. An unusually large number of such examinations on patients with cancer was available at Montefiore Hospital. An analysis of the findings in this group is presented. MATERIAL During the period from 1938 to 1947, there were 595 complete necropsies performed upon patients who died with cancer. In all these instances the brain was examined, but the spinal cord was studied in only 76 cases. Cases without cancer and those in which examination of the central nervous system was not performed were excluded from consideration in this paper. Metastatic lesions in the central nervous system or meninges were found in 207 cases (35% of the total of 595 necropsies).The primary and metastatic tumors were studied with hematoxylin and eosin preparations in all cases. Special stains, including References 1. References 8 and 9. 2. References 10 and 11. 3. References 8 and 9. 4. References 8 and 12. 5. References 15 and 16. 6. Krasting, K.: Beitrag zur Statistik und Kasuistik metastatischer Tumoren, besonders der Carcinommetastasen im Zentralnervensystem , Ztschr. Krebsforsch. 4:315, 1906.Crossref 7. Rau, W.: Eine vergleichende Statistik der in 5 Kriegsjahren und 5 Friedensjahren sezierten Fälle von Krebs und anderen malignen Tumoren , Ztschr. Krebsforsch. 18:141, 1922Crossref 8. Neustaedter, M.: Incidence of Metastases to the Nervous System , Arch. Neurol. & Psychiat. 51:423, 1944. 9. Baker, A. B.: Metastatic Tumors of the Nervous System , Arch. Path. 34:495, 1942. 10. Courville, C. B.: Pathology of the Central Nervous System , Mountain View, Calif., Pacific Press Publishing Association, 1945. 11. Willis, R.: Pathology of Tumors , St. Louis, Mo., C. V. Mosby Company, 1948. 12. Abrams, H. L.; Spiro, R., and Goldstein, N.: Metastases in Carcinoma , Cancer 3:74, 1950. 13. Globus, J. H., and Meltzer, T.: Metastatic Tumors of the Brain , Arch. Neurol. & Psychiat. 48:163, 1942. 14. Rupp, C.: Metastatic Tumors of the Central Nervous System: I. Intracerebral Metastases as the Only Evidence of Dissemination of Visceral Cancer , Arch. Neurol. & Psychiat. 59:635, 1948. 15. Dunlap, H. F.: Metastatic Malignant Tumors of the Brain , Ann. Int. Med. 5:1274, 1932. 16. Hare, C. C., and Schwarz, G. A.: Intracerebral Carcinomatous Metastases , Arch. Int. Med. 64:542, 1939. 17. Elkington, J. St. C.: Metastatic Tumors of the Brain , Proc. Roy. Soc. Med. 28:1080, 1935. 18. Berkman, J.; Netsky, M. G., and Zimmerman, H. M.: Malignant Lymphomas Within the Central Nervous System , to be published. 19. Batson, O. V.: Function of the Vertebral Veins and Their Role in the Spread of Metastases , Ann. Surg. 112:138, 1940. 20. Anderson, R.: Diodrast Studies of the Vertebral and Cranial Venous Systems , J. Neurosurg. 8:411, 1951. 21. Coman, D. R., and deLong, R. P.: Role of the Vertebral Venous System in Metastasis of Cancer to Spinal Column: Experiments with Tumor-Cell Suspensions in Rats and Rabbits , Cancer 4:610, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

METASTASIS OF NEOPLASMS TO THE CENTRAL NERVOUS SYSTEM AND MENINGES

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Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1954.02330020001001
Publisher site
See Article on Publisher Site

Abstract

Abstract THERE ARE few reports of metastatic neoplasms in the central nervous system and meninges based on study of a large series of complete necropsies. An unusually large number of such examinations on patients with cancer was available at Montefiore Hospital. An analysis of the findings in this group is presented. MATERIAL During the period from 1938 to 1947, there were 595 complete necropsies performed upon patients who died with cancer. In all these instances the brain was examined, but the spinal cord was studied in only 76 cases. Cases without cancer and those in which examination of the central nervous system was not performed were excluded from consideration in this paper. Metastatic lesions in the central nervous system or meninges were found in 207 cases (35% of the total of 595 necropsies).The primary and metastatic tumors were studied with hematoxylin and eosin preparations in all cases. Special stains, including References 1. References 8 and 9. 2. References 10 and 11. 3. References 8 and 9. 4. References 8 and 12. 5. References 15 and 16. 6. Krasting, K.: Beitrag zur Statistik und Kasuistik metastatischer Tumoren, besonders der Carcinommetastasen im Zentralnervensystem , Ztschr. Krebsforsch. 4:315, 1906.Crossref 7. Rau, W.: Eine vergleichende Statistik der in 5 Kriegsjahren und 5 Friedensjahren sezierten Fälle von Krebs und anderen malignen Tumoren , Ztschr. Krebsforsch. 18:141, 1922Crossref 8. Neustaedter, M.: Incidence of Metastases to the Nervous System , Arch. Neurol. & Psychiat. 51:423, 1944. 9. Baker, A. B.: Metastatic Tumors of the Nervous System , Arch. Path. 34:495, 1942. 10. Courville, C. B.: Pathology of the Central Nervous System , Mountain View, Calif., Pacific Press Publishing Association, 1945. 11. Willis, R.: Pathology of Tumors , St. Louis, Mo., C. V. Mosby Company, 1948. 12. Abrams, H. L.; Spiro, R., and Goldstein, N.: Metastases in Carcinoma , Cancer 3:74, 1950. 13. Globus, J. H., and Meltzer, T.: Metastatic Tumors of the Brain , Arch. Neurol. & Psychiat. 48:163, 1942. 14. Rupp, C.: Metastatic Tumors of the Central Nervous System: I. Intracerebral Metastases as the Only Evidence of Dissemination of Visceral Cancer , Arch. Neurol. & Psychiat. 59:635, 1948. 15. Dunlap, H. F.: Metastatic Malignant Tumors of the Brain , Ann. Int. Med. 5:1274, 1932. 16. Hare, C. C., and Schwarz, G. A.: Intracerebral Carcinomatous Metastases , Arch. Int. Med. 64:542, 1939. 17. Elkington, J. St. C.: Metastatic Tumors of the Brain , Proc. Roy. Soc. Med. 28:1080, 1935. 18. Berkman, J.; Netsky, M. G., and Zimmerman, H. M.: Malignant Lymphomas Within the Central Nervous System , to be published. 19. Batson, O. V.: Function of the Vertebral Veins and Their Role in the Spread of Metastases , Ann. Surg. 112:138, 1940. 20. Anderson, R.: Diodrast Studies of the Vertebral and Cranial Venous Systems , J. Neurosurg. 8:411, 1951. 21. Coman, D. R., and deLong, R. P.: Role of the Vertebral Venous System in Metastasis of Cancer to Spinal Column: Experiments with Tumor-Cell Suspensions in Rats and Rabbits , Cancer 4:610, 1951.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Aug 1, 1954

References