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METABOLISM OF CREATINE AND GUANIDOACETIC ACID IN PREMATURE AND FULL-TERM INFANTS

METABOLISM OF CREATINE AND GUANIDOACETIC ACID IN PREMATURE AND FULL-TERM INFANTS PREMATURE infants excrete much less creatine in the urine than young full-term infants, whose urinary creatine may amount to approximately 40% of the total creatinine.1 The present investigation was planned to clarify some of the mechanisms accounting for this difference. Studies were made on the effect of feeding creatine or its precursors on the excretion of creatine, creatinine, and guanidoacetic acid by these infants. In other observations, blood levels of creatine and creatinine were determined in relation to urinary excretion. Analyses were also made of the creatine content of muscle at various stages of fetal development. The results suggest that the premature infant stores or utilizes creatine to a greater extent than does the full-term infant. METHODS Observations were made on boy babies who were given partially skimmed cow's milk-carbohydrate feeding mixtures of approximately 110 to 130 calories per kilogram of body weight per day with added vitamins A, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

METABOLISM OF CREATINE AND GUANIDOACETIC ACID IN PREMATURE AND FULL-TERM INFANTS

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Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1953.02050080767006
Publisher site
See Article on Publisher Site

Abstract

PREMATURE infants excrete much less creatine in the urine than young full-term infants, whose urinary creatine may amount to approximately 40% of the total creatinine.1 The present investigation was planned to clarify some of the mechanisms accounting for this difference. Studies were made on the effect of feeding creatine or its precursors on the excretion of creatine, creatinine, and guanidoacetic acid by these infants. In other observations, blood levels of creatine and creatinine were determined in relation to urinary excretion. Analyses were also made of the creatine content of muscle at various stages of fetal development. The results suggest that the premature infant stores or utilizes creatine to a greater extent than does the full-term infant. METHODS Observations were made on boy babies who were given partially skimmed cow's milk-carbohydrate feeding mixtures of approximately 110 to 130 calories per kilogram of body weight per day with added vitamins A,

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Dec 1, 1953

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