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ORIGINAL INVESTIGATION Metabolic Syndrome and Mortality in Older Adults The Cardiovascular Health Study Dariush Mozaffarian, MD, DrPH; Aruna Kamineni, MPH; Ronald J. Prineas, MD, PhD; David S. Siscovick, MD, MPH Background: The utility of metabolic syndrome (MetS) with MetS had a 22% higher mortality (RR, 1.22; 95% for predicting mortality among older adults, the highest- confidence interval [CI], 1.11-1.34). Higher risk with MetS risk population, is not well established. In addition, few was confined to persons having elevated fasting glucose studies have compared the predictive utility of MetS to level (EFG) (defined as 110 mg/dL [ 6.1 mmol/L] or that of its individual risk factors. treated diabetes mellitus) (RR, 1.41; 95% CI, 1.27-1.57) or hypertension (RR, 1.26; 95% CI, 1.15-1.39) as one of the criteria; persons having MetS without EFG (RR, 0.97; Methods: We evaluated relationships of MetS (as de- 95% CI, 0.85-1.11) or MetS without hypertension (RR, fined by the National Cholesterol Education Program Ex- 0.92; 95% CI, 0.71-1.19) did not have higher risk. Evalu- pert Panel on Detection, Evaluation, and Treatment of ating MetS criteria individually, we found that only hy- High Blood Cholesterol in Adults [Adult Treatment Panel pertension and EFG predicted higher mortality; per-
JAMA Internal Medicine – American Medical Association
Published: May 12, 2008
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