Abstract LUPUS erythematosus has been tentatively classified as one of the so-called collagen, or mesenchymal, diseases, not only as a result of the pathological work which has demonstrated fibrinoid degeneration1 possibly due to precipitation of mucopolysaccharides from collagen ground substance2 but also on the basis of the clinical response of the acute forms of the disease to adrenal cortical substitution or stimulation.3 Recent extensive histological studies of the skin lesions by the Mayo group4 stress vascular involvement in all stages of the disease and support the report that there is demonstrable interference with fluid exchange between vessels and tissue spaces.5 The characteristic lesions of the skin are apparently not the primary manifestation of lupus erythematosus in that they do not account for the systemic pathology. Beyond the demonstration of the L. E. cell in acute forms of the disease6 there are several other suggestive systemic References 1. Klemperer, P.; Pollack, A. D., and Baehr, G.: Pathology of Disseminated Lupus Erythematosus , Arch. Path. 32:569 ( (Oct.) ) 1941. 2. Klemperer, P.: The Pathogenesis of Lupus Erythematosus and Allied Conditions , Ann. Int. Med. 28:1, 1948.Crossref 3. Altshuler, C. H., and Angevine, D. M.: Histochemical Studies on the Pathogenesis of Fibrinoid , Am. J. Path. 25:1061, 1949. 4. Thorn, G. H.; Bayles, T. B.; Massell, B. F.; Forsham, P. H.; Hill, R. S.; Smith, S., III, and Warren, J. E.: Medical Progress: Studies on the Relation of Pituitary-Adrenal Function to Rheumatic Disease , New England J. Med. 241:529, 1949.Crossref 5. McCreight, W. G., and Montgomery, H.: Cutaneous Changes in Lupus Erythematosus: Histopathologic Aspects, with Special Reference to Vascular Changes , Arch. Dermat. & Syph. 61:1 ( (Jan.) ) 1950. 6. Kanof, N. B.: Physiologic Alterations in Lupus Erythematosus , New York State J. Med. 50:2443 ( (Oct. 15) ) 1950. 7. Haserick, J. R., and Sundberg, R. D.: The Bone Marrow as a Diagnostic Aid in Acute Disseminated Lupus Erythematosus , J. Invest. Dermat. 11:209, 1948. 8. White, C. J.: The Problems of Positive Serological Tests for Syphilis in Lupus Erythematosus , Am. J. Syph., Gonor. & Ven. Dis. 31:235, 1947. 9. Baehr, G., and Soffer, L. J.: Treatment of Disseminated Lupus Erythematosus with Cortisone and Adrenocorticotropin , Bull. New York Acad. Med. 26:229, 1950. 10. Elkinton, J. R.; Hunt, A. D.; Godfrey, L.; McCrory, W. W.; Rogerson, A. G., and Stokes, J., Jr.: Effects of Pituitary Adrenocorticotropic Hormone (ACTH) Therapy , J. A. M. A. 141:1273 ( (Dec. 31) ) 1949. 11. Hartman, F. A., and Liu, T. Y.: Secretion of Fat Factor of the Adrenal , Federation Proc. 9:57, 1950. 12. Hartman, F. A., and Brownell, K. A.: The Adrenal Gland , Philadelphia, Lea & Febiger, 1949.
A.M.A. Archives of Dermatology & Syphilology – American Medical Association
Published: Jan 1, 1951