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Mesectodermal Leiomyoma of the Ciliary Body: An Ultrastructural Study

Mesectodermal Leiomyoma of the Ciliary Body: An Ultrastructural Study Abstract • Electron microscopic observation of a mesectodermal leiomyoma of the ciliary body, in which clear perinuclear halos were present, revealed the ultrastructural characteristics of smooth muscle cells, which include myofilaments with fusiform densities, dense attachments, external lamina, and pinocytotic vesicles. In addition, fibrillary cytoplasmic processes containing large numbers of myofilaments with fusiform densities were notably arranged in a neurogenic pattern when observed under a light microscope. These are characteristic of and specific to mesectodermal leiomyomas. Masses or cords of large, polygonal cells with clear halos surrounding the large, round-to-oval nuclei were found to contain only a few myofilaments. Such features are atypical of mesectodermal leiomyomas. Melanocytes were scattered throughout the tumor, providing additional evidence for the neural crest theory of origination of mesectodermal leiomyomas, since melanocytes are well-recognized descendants of the neural crest. A small number of lipid droplets, abundant lysosomes, and, occasionally, phagosomes were also observed in the cells of this mesectodermal leiomyoma. References 1. Yanoff M, Fine BS: Ocular Pathology: A Text and Atlas , ed 2. New York, Harper & Row Publishers Inc, 1982, pp 420-430. 2. Jakobiec FA, Witschel H, Zimmerman LE: Choroidal leiomyoma of vascular origin . Am J Ophthalmol 1976;82:205-212. 3. Robbins SL, Cotran RS: Pathologic Basis of Disease , ed 2. Philadelphia, WB Saunders Co, 1979, pp 209-211. 4. Jakobiec FA, Font RL, Tso MOM, et al: Mesectodermal leiomyoma of the ciliary body: A tumor of presumed neural crest origin . Cancer 1977;39:2102-2113.Crossref 5. Jakobiec FA, Iwamoto T: Mesectodermal leiomyoma of the ciliary body associated with a nevus . Arch Ophthalmol 1978;96:692-695.Crossref 6. Croxatto JO, Malbran ES: Unusual ciliary body tumor: Mesectodermal leiomyoma . Ophthalmology 1982;89:1208-1212.Crossref 7. Salazar H, Totten RS: Leiomyoblastoma of the stomach: An ultrastructural study . Cancer 1970;25:176-185. 8. Lavin P, Hajdu SI, Foote FW Jr: Gastric and extragastric leiomyoblastomas: Clinicopathologic study of 44 cases . Cancer 1972;29:305-311.Crossref 9. Goldfischer S, Schiller B, Wolinsky H: Lipid accumulation in smooth muscle cell lysosomes in primate atherosclerosis . Am J Pathol 1975; 78:497-504. 10. Takagi T, Leszczynski D, Toda T, et al: Ultrastructure of human umbilical artery and vein: Characterization and quantification of lipid-laden cells . Acta Pathol Jpn 1985;35:1047-1055. 11. Joris I, Majno G: Cellular breakdown within the arterial wall: An ultrastructural study of the coronary artery in young and aging rats . Virchows Arch Pathol Anat 1974;364:111-127.Crossref 12. Daoud AS, Jones R, Scott RF, et al: Dietary-induced atherosclerosis in miniature swine . Exp Mol Pathol 1968;8:263-301.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Mesectodermal Leiomyoma of the Ciliary Body: An Ultrastructural Study

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1985.01050110105037
Publisher site
See Article on Publisher Site

Abstract

Abstract • Electron microscopic observation of a mesectodermal leiomyoma of the ciliary body, in which clear perinuclear halos were present, revealed the ultrastructural characteristics of smooth muscle cells, which include myofilaments with fusiform densities, dense attachments, external lamina, and pinocytotic vesicles. In addition, fibrillary cytoplasmic processes containing large numbers of myofilaments with fusiform densities were notably arranged in a neurogenic pattern when observed under a light microscope. These are characteristic of and specific to mesectodermal leiomyomas. Masses or cords of large, polygonal cells with clear halos surrounding the large, round-to-oval nuclei were found to contain only a few myofilaments. Such features are atypical of mesectodermal leiomyomas. Melanocytes were scattered throughout the tumor, providing additional evidence for the neural crest theory of origination of mesectodermal leiomyomas, since melanocytes are well-recognized descendants of the neural crest. A small number of lipid droplets, abundant lysosomes, and, occasionally, phagosomes were also observed in the cells of this mesectodermal leiomyoma. References 1. Yanoff M, Fine BS: Ocular Pathology: A Text and Atlas , ed 2. New York, Harper & Row Publishers Inc, 1982, pp 420-430. 2. Jakobiec FA, Witschel H, Zimmerman LE: Choroidal leiomyoma of vascular origin . Am J Ophthalmol 1976;82:205-212. 3. Robbins SL, Cotran RS: Pathologic Basis of Disease , ed 2. Philadelphia, WB Saunders Co, 1979, pp 209-211. 4. Jakobiec FA, Font RL, Tso MOM, et al: Mesectodermal leiomyoma of the ciliary body: A tumor of presumed neural crest origin . Cancer 1977;39:2102-2113.Crossref 5. Jakobiec FA, Iwamoto T: Mesectodermal leiomyoma of the ciliary body associated with a nevus . Arch Ophthalmol 1978;96:692-695.Crossref 6. Croxatto JO, Malbran ES: Unusual ciliary body tumor: Mesectodermal leiomyoma . Ophthalmology 1982;89:1208-1212.Crossref 7. Salazar H, Totten RS: Leiomyoblastoma of the stomach: An ultrastructural study . Cancer 1970;25:176-185. 8. Lavin P, Hajdu SI, Foote FW Jr: Gastric and extragastric leiomyoblastomas: Clinicopathologic study of 44 cases . Cancer 1972;29:305-311.Crossref 9. Goldfischer S, Schiller B, Wolinsky H: Lipid accumulation in smooth muscle cell lysosomes in primate atherosclerosis . Am J Pathol 1975; 78:497-504. 10. Takagi T, Leszczynski D, Toda T, et al: Ultrastructure of human umbilical artery and vein: Characterization and quantification of lipid-laden cells . Acta Pathol Jpn 1985;35:1047-1055. 11. Joris I, Majno G: Cellular breakdown within the arterial wall: An ultrastructural study of the coronary artery in young and aging rats . Virchows Arch Pathol Anat 1974;364:111-127.Crossref 12. Daoud AS, Jones R, Scott RF, et al: Dietary-induced atherosclerosis in miniature swine . Exp Mol Pathol 1968;8:263-301.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1985

References