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Merkel Cell Tumor of the Head and Neck Five New Cases With Literature Review

Merkel Cell Tumor of the Head and Neck Five New Cases With Literature Review Abstract • Merkel cell carcinoma (MCC) of the skin is an uncommon, but highly aggressive neoplasm with a marked propensity for local and distant metastasis. Despite the fact that more than half of the 600 cases of MCC reported in the literature involved primary sites in the head and neck, MCC has rarely been discussed in otolaryngology publications. We present five new cases of MCC of the head and neck and summarize 89 additional cases from the literature in which detailed treatment and survival data were given. Our findings again emphasize the difficulty in making the initial histopathologic diagnosis of MCC and demonstrate the necessity of early diagnosis and multimodality treatment. (Arch Otolaryngol Head Neck Surg. 1993;119:782-786) References 1. Toker C. Trabecular carcinoma of the skin . Arch Dermatol . 1972;105: 107-110.Crossref 2. Sibley RK, Dahl D. Primary neuroendocrine (Merkel cell?) carcinoma of the skin: an immunocytochemical study of 21 cases . Am J Surg Pathol . 1985;9:109-116.Crossref 3. Taxy JB, Ettinger DS, Wharam MD. Primary small cell carcinoma of the skin . Cancer . 1980;46:2308-2311.Crossref 4. De Wolf-Peeters C, Marien K, Mebis J, Desmet V. A cutaneous APUDoma or Merkel cell tumor . Cancer . 1980;46:1810-1816.Crossref 5. Leong AS, Phillips GE, Pieterse AS, Milios J. Criteria for the diagnosis of primary endocrine carcinoma of the skin (Merkel cell carcinoma): a histological, immunohistochemical and ultrastructural study of 13 cases . Pathology . 1986;18:393-399.Crossref 6. Heenan PJ, Cole JM, Spagnolo DV. Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor) . Am J Dermatopathol . 1990;12:7-16.Crossref 7. Goepfert H, Remmler D, Silva E, Wheeler B. Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck . Arch Otolaryngol . 1984;110:707-712.Crossref 8. Tennvall J, Biorklund A, Johannsson L, Akerman M. Merkel cell carcinoma: management of primary, recurrent and metastatic disease: a clinicopathological study of 17 patients . Eur J Surg Oncol . 1989;15:1-9. 9. Pilotti S, Rilke F, Lombardi L. Neuroendocrine (Merkel cell) carcinoma of the skin . Am J Surg Pathol . 1982;6:243-254.Crossref 10. O'Brien PC, Denham JW, Leong S-Y. Merkel cell carcinoma: a review of behavior patterns and management strategies . Aust N Z J Surg . 1987;57: 847-850.Crossref 11. Silva EG, Mackay B, Goepfert H, Burgess MA, Fields RS. Endocrine carcinoma of the skin (Merkel cell carcinoma) . Pathol Annu . 1984;19:1-30. 12. George TK, Di Sant'Agnese PA, Bennett JM. Chemotherapy for metastatic Merkel cell carcinoma . Cancer . 1985;56:1034-1038.Crossref 13. Sibley RK, Dehner LP, Rosai J. Primary neuroendocrine (Merkel cell) carcinoma of the skin . Am J Surg Pathol . 1985;9:95-108.Crossref 14. Merkel F. Tastzellen und Tastkörprechen bei den Hausthieren und beim Menschen . Arch Mikrosc Anat . 1875;11:636-652.Crossref 15. Knox SJ, Kapp DS. Hyperthermia and radiation therapy in the treatment of recurrent Merkel cell tumors . Cancer . 1988;62:1479-1486.Crossref 16. Gould VE, DeLellis RA. The neuroendocrine system . In: Silverberg SG, ed. Principles and Practice of Surgical Pathology . New York, NY: Churchill Livingstone Inc; 1990:chap 48. 17. Tang CK, Toker C. Trabecular carcinoma of the skin . Cancer . 1978; 42:2311-2321.Crossref 18. Layfield L, Ulich T, Liao S, Barr R, Cheng L, Lewin KL. Neuroendocrine carcinoma of the skin: an immunohistochemical study of tumor markers and neuroendocrine products . J Cutan Pathol . 1986;13:268-273.Crossref 19. Visscher D, Cooper PH, Zarbo RJ, Crissman JD. Cutaneous neuroendocrine (Merkel cell) carcinoma: an immunophenotypic, clinicopathologic, and flow cytometric study . Mod Pathol . 1989;2:331-338. 20. Tang CK, Toker C. Trabecular carcinoma of the skin: further clinicopathologic and ultrastructural study . Mt Sinai J Med . 1979;46:516-523. 21. Pilotti S, Rilke F, Bartoli C, Grisotti A. Clinicopathologic correlation of cutaneous neuroendocrine Merkel cell carcinoma . J Clin Oncol . 1988;6: 1863-1873. 22. Shaw JHF, Rumball E. Merkel cell tumour: clinical behaviour and treatment . Br J Surg . 1991;78:138-142.Crossref 23. Hanke CW, Conner AC, Temofeew RK, Lingeman RE. Merkel cell carcinoma . Arch Dermatol . 1989;125:1096-1100.Crossref 24. Cotlar AM, Gates JO, Gibbs FA. Merkel cell carcinoma: combined surgery and radiation therapy . Am Surg . 1986;52:159-164. 25. Hitchcock CL, Bland KI, Laney RG III, Franzini D, Harris B, Copeland EM III. Neuroendocrine (Merkel cell) carcinoma of the skin . Ann Surg . 1988; 207:201-207.Crossref 26. Morrison WH, Peters LJ, Silva EG, Wendt CD, Ang KK, Goepfert H. The essential role of radiation therapy in securing locoregional control of Merkel cell carcinoma . Int J Radiat Oncol Biol Phys . 1990;19:583-591.Crossref 27. Feun LG, Savaraj N, Legha SS, Silva EG, Benjamin RS, Burgess MA. Chemotherapy for metastatic Merkel cell carcinoma . Cancer . 1988;62:683-685.Crossref 28. Wynne CJ, Kearsley JH. Merkel cell tumor . Cancer . 1988;62:28-31.Crossref 29. Crown J, Lipzstein R, Cohen S, et al. Chemotherapy of metastatic Merkel cell cancer . Cancer Invest . 1991;9:129-132.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Merkel Cell Tumor of the Head and Neck Five New Cases With Literature Review

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Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1993.01880190078016
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Abstract

Abstract • Merkel cell carcinoma (MCC) of the skin is an uncommon, but highly aggressive neoplasm with a marked propensity for local and distant metastasis. Despite the fact that more than half of the 600 cases of MCC reported in the literature involved primary sites in the head and neck, MCC has rarely been discussed in otolaryngology publications. We present five new cases of MCC of the head and neck and summarize 89 additional cases from the literature in which detailed treatment and survival data were given. Our findings again emphasize the difficulty in making the initial histopathologic diagnosis of MCC and demonstrate the necessity of early diagnosis and multimodality treatment. (Arch Otolaryngol Head Neck Surg. 1993;119:782-786) References 1. Toker C. Trabecular carcinoma of the skin . Arch Dermatol . 1972;105: 107-110.Crossref 2. Sibley RK, Dahl D. Primary neuroendocrine (Merkel cell?) carcinoma of the skin: an immunocytochemical study of 21 cases . Am J Surg Pathol . 1985;9:109-116.Crossref 3. Taxy JB, Ettinger DS, Wharam MD. Primary small cell carcinoma of the skin . Cancer . 1980;46:2308-2311.Crossref 4. De Wolf-Peeters C, Marien K, Mebis J, Desmet V. A cutaneous APUDoma or Merkel cell tumor . Cancer . 1980;46:1810-1816.Crossref 5. Leong AS, Phillips GE, Pieterse AS, Milios J. Criteria for the diagnosis of primary endocrine carcinoma of the skin (Merkel cell carcinoma): a histological, immunohistochemical and ultrastructural study of 13 cases . Pathology . 1986;18:393-399.Crossref 6. Heenan PJ, Cole JM, Spagnolo DV. Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor) . Am J Dermatopathol . 1990;12:7-16.Crossref 7. Goepfert H, Remmler D, Silva E, Wheeler B. Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck . Arch Otolaryngol . 1984;110:707-712.Crossref 8. Tennvall J, Biorklund A, Johannsson L, Akerman M. Merkel cell carcinoma: management of primary, recurrent and metastatic disease: a clinicopathological study of 17 patients . Eur J Surg Oncol . 1989;15:1-9. 9. Pilotti S, Rilke F, Lombardi L. Neuroendocrine (Merkel cell) carcinoma of the skin . Am J Surg Pathol . 1982;6:243-254.Crossref 10. O'Brien PC, Denham JW, Leong S-Y. Merkel cell carcinoma: a review of behavior patterns and management strategies . Aust N Z J Surg . 1987;57: 847-850.Crossref 11. Silva EG, Mackay B, Goepfert H, Burgess MA, Fields RS. Endocrine carcinoma of the skin (Merkel cell carcinoma) . Pathol Annu . 1984;19:1-30. 12. George TK, Di Sant'Agnese PA, Bennett JM. Chemotherapy for metastatic Merkel cell carcinoma . Cancer . 1985;56:1034-1038.Crossref 13. Sibley RK, Dehner LP, Rosai J. Primary neuroendocrine (Merkel cell) carcinoma of the skin . Am J Surg Pathol . 1985;9:95-108.Crossref 14. Merkel F. Tastzellen und Tastkörprechen bei den Hausthieren und beim Menschen . Arch Mikrosc Anat . 1875;11:636-652.Crossref 15. Knox SJ, Kapp DS. Hyperthermia and radiation therapy in the treatment of recurrent Merkel cell tumors . Cancer . 1988;62:1479-1486.Crossref 16. Gould VE, DeLellis RA. The neuroendocrine system . In: Silverberg SG, ed. Principles and Practice of Surgical Pathology . New York, NY: Churchill Livingstone Inc; 1990:chap 48. 17. Tang CK, Toker C. Trabecular carcinoma of the skin . Cancer . 1978; 42:2311-2321.Crossref 18. Layfield L, Ulich T, Liao S, Barr R, Cheng L, Lewin KL. Neuroendocrine carcinoma of the skin: an immunohistochemical study of tumor markers and neuroendocrine products . J Cutan Pathol . 1986;13:268-273.Crossref 19. Visscher D, Cooper PH, Zarbo RJ, Crissman JD. Cutaneous neuroendocrine (Merkel cell) carcinoma: an immunophenotypic, clinicopathologic, and flow cytometric study . Mod Pathol . 1989;2:331-338. 20. Tang CK, Toker C. Trabecular carcinoma of the skin: further clinicopathologic and ultrastructural study . Mt Sinai J Med . 1979;46:516-523. 21. Pilotti S, Rilke F, Bartoli C, Grisotti A. Clinicopathologic correlation of cutaneous neuroendocrine Merkel cell carcinoma . J Clin Oncol . 1988;6: 1863-1873. 22. Shaw JHF, Rumball E. Merkel cell tumour: clinical behaviour and treatment . Br J Surg . 1991;78:138-142.Crossref 23. Hanke CW, Conner AC, Temofeew RK, Lingeman RE. Merkel cell carcinoma . Arch Dermatol . 1989;125:1096-1100.Crossref 24. Cotlar AM, Gates JO, Gibbs FA. Merkel cell carcinoma: combined surgery and radiation therapy . Am Surg . 1986;52:159-164. 25. Hitchcock CL, Bland KI, Laney RG III, Franzini D, Harris B, Copeland EM III. Neuroendocrine (Merkel cell) carcinoma of the skin . Ann Surg . 1988; 207:201-207.Crossref 26. Morrison WH, Peters LJ, Silva EG, Wendt CD, Ang KK, Goepfert H. The essential role of radiation therapy in securing locoregional control of Merkel cell carcinoma . Int J Radiat Oncol Biol Phys . 1990;19:583-591.Crossref 27. Feun LG, Savaraj N, Legha SS, Silva EG, Benjamin RS, Burgess MA. Chemotherapy for metastatic Merkel cell carcinoma . Cancer . 1988;62:683-685.Crossref 28. Wynne CJ, Kearsley JH. Merkel cell tumor . Cancer . 1988;62:28-31.Crossref 29. Crown J, Lipzstein R, Cohen S, et al. Chemotherapy of metastatic Merkel cell cancer . Cancer Invest . 1991;9:129-132.Crossref

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Jul 1, 1993

References