Access the full text.
Sign up today, get DeepDyve free for 14 days.
Thompson RW Griffin JW (1971)
Lymphomatous leptomeningitisAnn J Med, 51
D. Dawson, D. Rosenthal, W. Moloney (1973)
Neurological complications of acute leukemia in adults: changing rate.Annals of internal medicine, 79 4
T. Herman, N. Hammond, S. Jones, J. Butler, G. Byrne, E. McKelvey (1979)
Involvement of the central nervous system by non‐Hodgkin's lymphoma. The southwest oncology group experienceCancer, 43
Jacquillat C Bernard J (1972)
Treatment of the acute leukemiasSemin Hematol, 9
R. West, J. Graham-Pole, R. Hardisty, M. Pike (1972)
Factors in Pathogenesis of Central-nervous-system LeukaemiaBritish Medical Journal, 3
Rich SR (1972)
A membrane filter technique of cerebrospinal fluid cytologyJ Neurosurg, 37
E. Sadar, R. Walton, H. Gossman (1972)
Neurological dysfunction in Paget's disease of the vertebral column.Journal of neurosurgery, 37 6
C. Pochedly (1977)
Leukemia and lymphoma in the nervous system
I. Law, J. Blom (1977)
Adult acute leukemia. Frequency of central nervous system involvement in long term survivorsCancer, 40
Blom J Law IP (1977)
Adult acute leukemiaCancer, 40
Kjellin KG Siden A (1977)
Isoelectric focusing of CSF and serum proteins in neurological disorders combined with benign and malignant proliferations of reticulocytes, lymphocytes and plasmocytesJ Neurol, 216
R. Aur, H. Hustu, M. Verzosa, A. Wood, J. Simone (1973)
Comparison of two methods of preventing central nervous system leukemia.Blood, 42 3
B. Drewinko, M. Sullivan, T. Martin (1973)
Use of the cytocentrifuge in the diagnosis of meningeal leukemiaCancer, 31
Rizzo SC Fontana G (1975)
Prophylaxis and therapy of neuromeningeal involvement of acute lymphoblastic leukemia: Case report and critical review of literatureHaematologica, 60
D. Enzmann, J. Krikorian, C. Yorke, R. Hayward (1978)
Computed tomography in leptomeningeal spread of tumor.Journal of computer assisted tomography, 2 4
Schwarzenberg L Pouillart P (1972)
Les m�ningites lymphoblastiques: Incidence, pr�vention et tratementPresse Med, 6
Edith Reske-Nielsen, Petersen Jh, Helmer Søgaard, Kaj Jensen (1974)
Letter: Leukaemia of the central nervous system.Lancet, 1 7850
G. Fontana, S. Rizzo, E. Ascari, G. Ricevuti, C. Balduini, G. Santagati (1975)
[Prophylaxis and therapy of neuro-meningeal involvement of acute lymphoblastic leukemia. Case reports and critical review of literature (author's transl)].Haematologica, 60 2
Spiers ASD (1972)
Chemotherapy of acute leukaemiaClin Hematol, 1
Hammond N Herman TS (1979)
Involvement of the central nervous system by non-Hodgkin's lymphomaCancer, 43
R. Wolk, S. Masse, R. Conklin, E. Freireich (1974)
The incidence of central nervous system leukemia in adults with acute leukemiaCancer, 33
C. Zachariah, H. Grünwald, F. Rosner (1978)
Prolonged meningeal leukemia. Occurrence during hematologic remission of acute myeloblastic leukemia.JAMA, 239 14
Hansen Hh, Bender Ra, Shelton Bj (1974)
The cyto-centrifuge and cerebrospinal fluid cytology.Acta Cytologica, 18
Clink HM McElwain JJ (1979)
CNS Complications of Malignant Disease
J. Gastaut, J. Gastaut, Y. Carcassonne (1978)
Computerized axial tomography in the study of intracranial complications in hematologyCancer, 41
T. Mcelwain, H. Clink, B. Jameson, H. Kay, R. Powles (1979)
Central Nervous System Involvement in Acute Myelogenous Leukaemia
Firth JL Spiers ASD (1972)
Treating the nervous system in acute leukemiaLancet, 1
J. Bernard (1962)
[Treatment of acute leukemias].Les Cahiers du College de medecine des hopitaux de Paris, 3
Grünwald HW Zachariah C (1978)
Prolonged meningeal leukemiaJAMA, 239
Lieberman M Fitzpatric KJ (1974)
Staging of acute leukemia and the relationship to CNS involvementCancer, 33
J. Fitzpatrick, N. Lieberman, L. Sinks (1974)
Staging of acute leukemia and the relationship to CNS involvement. Staging of all and CNS diseaseCancer, 33
A. Spiers (1972)
Chemotherapy of acute leukaemiaClinics in haematology, 1
Beard Me, Fairley Gh (1974)
Acute leukemia in adults.Seminars in Hematology, 11
Kay HEM (1982)
Recent Advances in Hematology
E. Getaz, Gary Miller (1979)
Spinal cord involvement in chronic lymphocytic leukemiaCancer, 43
Petersen JH Reske-Nielsen E (1974)
Leukaemia of the central nervous systemLancet, 9
Abstract • Owing to improved therapy and lengthened life span, the incidence of neuromeningeal involvement in leukemia is increasing. Careful examination of the cerebrospinal fluid (CSF) is important for an early diagnosis. Among the available techniques, the use of cytocentrifugation enables us to demonstrate central nervous system leukemia even if the white blood cell count in the CSF is under 10/cu mm. We describe the results obtained by examining 631 CSF samples from 87 patients affected by acute leukemia; central nervous system luekemia was found in 22.7% of the patients suffering from acute lymphocytic leukemia and in 6.4% of those with acute nonlymphocytic leukemia (ANLL), but this ratio is higher in ANLL compared with the survival as measured in months (a ratio of 2.0 in ANLL compared with 0.50 in acute lymphocytic leukemia). A "leukemic" CSF was found in 51.5% of prophylactically treated patients and in 73.1% of the untreated ones. References 1. References 1, 3, 5, 7,10, 12-14, 18, 20. 2. References 1, 4, 5, 9, 12, 13, 15, 20, 22-24, 26. 3. Fitzpatric KJ, Lieberman M, Sinks LF: Staging of acute leukemia and the relationship to CNS involvement . Cancer 1974;33:1376-1381.Crossref 4. Law IP, Blom J: Adult acute leukemia . Cancer 1977;40:1304-1306.Crossref 5. McElwain JJ, Clink HM, Kay HEM, et al: Central nervous system involvement in acute myelogenous leukemia , in Whitehouse JMA, Kay HEM (eds): CNS Complications of Malignant Disease . New York, Macmillan Publishing Co Inc, 1979, pp 91-120. 6. Reske-Nielsen E, Petersen JH, Sogaard H, et al: Leukaemia of the central nervous system . Lancet 1974;9:211-212.Crossref 7. Zachariah C, Grünwald HW, Rosner F: Prolonged meningeal leukemia . JAMA 1978;239:1423-1424.Crossref 8. West R, Craham-Pole J, Hardisty H, et al: Factors in pathogenesis of central nervous system leukaemia . Br Med J 1972;3:311-314.Crossref 9. Wolk RW, Masse SR, Conklin R, et al: The incidence of central nervous system leukemia in adults with acute leukemia . Cancer 1974;33:863-869.Crossref 10. Beard ME, Hamilton-Fairley G: Acute leukemia in adults . Semin Hematol 1974;11:5-24. 11. Bernard J, Jacquillat C, Weil M: Treatment of the acute leukemias . Semin Hematol 1972;9:181-191. 12. Dawson DM, Rosenthal DS, Moloney WC: Neurological complications of acute leukemia in adults: Changing rate . Ann Intern Med 1973;79:541-544.Crossref 13. Gétaz EP, Miller GJ: Spinal cord involvement in chronic lymphocytic leukemia . Cancer 1979;43:1858-1861.Crossref 14. Griffin JW, Thompson RW, Mitchinson MJ, et al: Lymphomatous leptomeningitis . Ann J Med 1971;51:200-208.Crossref 15. Pochedly C, Maner AM: Leukemia and Lymphoma in the Nervous System . Springfield, Ill, Charles C Thomas Publishers, 1977, p 88. 16. Fontana G, Rizzo SC, Ascari E, et al: Prophylaxis and therapy of neuromeningeal involvement of acute lymphoblastic leukemia: Case report and critical review of literature . Haematologica 1975;60:207-229. 17. Gastaut JA, Gastaut JL, Cercassonne Y: Computerized axial tomography in the study of intracranial complications in hematology . Cancer 1978;41:487-501.Crossref 18. Kay HEM: Acute leukemia , in Hoffbrand AV (ed): Recent Advances in Hematology . New York, Churchill Livingstone Inc, 1982, pp 61-82. 19. Herman TS, Hammond N, Jones SE, et al: Involvement of the central nervous system by non-Hodgkin's lymphoma . Cancer 1979;43:390-397.Crossref 20. Fontana G, Rizzo SC, Ascari E, et al: Therapy and prophylaxis of leukaemic meningeal complication by intrathecal administration of the association methotrexate and Ara C. Read before the second meeting of II° Meeting of the European African Division of the International Society of Haematology, Prague. 21. Spiers ASD, Firth JL: Treating the nervous system in acute leukemia . Lancet 1972;1:433.Crossref 22. Aur RJA, Hustu HO, Verzosa MS, et al: Comparison of two methods of preventing central nervous system leukemia . Blood 1973;42:349-357. 23. Drewinko B, Sullivan M, Martin T: Use of the cytocentrifuge in the diagnosis of meningeal leukaemia . Cancer 1973;31:1331-1336.Crossref 24. Enzmann DR, Krikorian J, York C: Computed tomography in leptomeningeal spread of tumor . J Comput Assist Tomogr 1978;2:448-455.Crossref 25. Hansen HH, Bender AR, Shelton BJ: The cytocentrifuge and cerebrospinal fluid cytology . Acta Cytol 1974;18:259-263. 26. Rich SR: A membrane filter technique of cerebrospinal fluid cytology . J Neurosurg 1972;37:661-666.Crossref 27. Siden A, Kjellin KG: Isoelectric focusing of CSF and serum proteins in neurological disorders combined with benign and malignant proliferations of reticulocytes, lymphocytes and plasmocytes . J Neurol 1977;216:251-261.Crossref 28. Pouillart P, Schwarzenberg L, Schneider M, et al: Les méningites lymphoblastiques: Incidence, prévention et tratement . Presse Med 1972;6:387-390. 29. Spiers ASD: Chemotherapy of acute leukaemia . Clin Hematol 1972;1:127-165.Crossref
Archives of Neurology – American Medical Association
Published: May 1, 1986
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.