Abstract Three cases of malignant melanoma resembling spindle and epithelioid cell nevus histologically are presented. Lesions having histologic features of spindle and epithelioid cell nevus (Spitz nevus or juvenile melanoma) at or after puberty should be regarded with caution, particularly when they are heavily melanized. Such lesions are in a histologic "gray zone" and may be malignant. (Arch Dermatol 115:1416-1420, 1979) References 1. Spitz S: Spindle and epithelioid cell nevi in the adult . Am J Pathol 25:591-609, 1948. 2. Echevarria R, Ackerman LV: Spindle and epithelioid cell nevi in the adult . Cancer 20:175-189, 1967.Crossref 3. Kernen JA, Ackerman LV: Spindle cell nevi and epithelioid cell nevi (so-called juvenile melanomas) in children and adults: A clinicopathological study of 27 cases . Cancer 13:612-625, 1960.Crossref 4. Helwig B: Malignant melanoma in children , in Freitag SB, Culhane DL, Demec JC (eds): Neoplasms of the Skin and Malignant Melanoma . Chicago, Year Book Medical Publishers Inc, 1976, p 19. 5. Paniago-Pereira C, Maize JC, Ackerman AB: Nevus of large spindle and/or epithelioid cells (Spitz's nevus) . Arch Dermatol 114:1811-1823, 1978.Crossref 6. Lever WF, Schaumburg-Lever G: Histopathology of the Skin . Philadelphia, JB Lippincott Co, 1975, p 671. 7. Okun M, Edelstein L: Gross and Microscopic Pathology of the Skin . Boston, Dermatopathology Foundation Press, 1976, vol 2, pp 958, 985. 8. McGovern V: Malignant Melanoma: Clinical and Histologic Diagnosis . New York, John Wiley & Sons Inc, 1976, p 149.
Archives of Dermatology – American Medical Association
Published: Dec 1, 1979
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