Abstract Zimmerman1 presented evidence of a locally invasive, nonmalignant, primary melanotic tumor of the optic disc which arose from normal uveal melanocytes. This tumor was benign, over half of the reported cases were in Negroes, and it offered an excellent prognosis. The distinctive name melanocytoma was used to differentiate this tumor from choroidal melanomas which involved the nerve head. Over 30 melanocytomas of the optic disc have been reported. There have been no reports of metastasis, but the tumors have been found to be locally invasive, infiltrating posterior to the lamina cribrosa and into the adjacent choroid. The most important distinguishing feature of this tumor is its benign clinical course which is characterized by slow growth and rare decrease in the patient's visual acuity. These observations have made it clear that enucleation is not necessary. Cytologically the cells are remarkably uniform and heavily laden with pigment granules which appear morphologically References 1. Zimmerman, L. E.: Pigmented Tumors of Optic Nerve Head: 22nd Annual Lecture in Honor of the Late Dr. George E. DeSchweinitz, 1959. 2. Hogan, M. J., and Zimmerman, L. E.: Ophthalmic Pathology: Atlas and Textbook , Philadelphia: W. B. Saunders Company, 1962. 3. Rones, B., and Zimmerman, L. E.: Prognosis of Primary Tumors of Iris Treated by Iridectomy , AMA Arch Ophthal 60:193-205, 1958.Crossref 4. Stallard, H. B.: Surgery of Malignant Melanoma of Iris , Brit J Ophthal 35:774-783, 1951.Crossref 5. Stallard, H. B.: Partial Cyclectomy , Brit J Ophthal 45:797-802, 1961.Crossref 6. Garron, L. K., and Zimmerman, L. E.: Melanocytoma of Optic Disc , Int Ophthal Clin 2:431-440, 1962.Crossref
Archives of Ophthalmology – American Medical Association
Published: May 1, 1964
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