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Melanocytoma of the Choroid Clinically Simulating a Malignant Melanoma

Melanocytoma of the Choroid Clinically Simulating a Malignant Melanoma Abstract A 46-year-old man was found on routine ophthalmoscopic examination to have a pigmented choroidal lesion that was suggestive of a malignant melanoma. Because of its clinical appearance, associated visual field defect, and the results of fluorescein angiography, the eye was enucleated. Histopathologically, the lesion proved to be a benign melanocytoma of the choroid. Although little is known about the fluorescein-angiographic characteristics of melanocytomas of the choroid, the fluorescein angiogram suggested a malignant melanoma. The advisability of a conservative approach to such small pigmented fundus lesions is reemphasized. References 1. Zimmerman LE, Garron LK: Melanocytoma of the optic disc . Int Ophthal Clin 2:431-440, 1962.Crossref 2. Zimmerman LE: Melanocytes, melanocytic nevi and melanocytomas . Invest Ophthal 4:11-41, 1965. 3. Naumann G, Yanoff M, Zimmerman LE: Histogenesis of malignant melanoma of the uvea: I. Histopathologic characteristics of nevi of the choroid and ciliary body . Arch Ophthal 76:784-796, 1966.Crossref 4. deVeer JA: Melanotic tumors of the optic nerve head: A pathologic study . Arch Ophthal 65:536-541, 1961.Crossref 5. Howard GM, Forrest AW: Incidence and location of melanocytomas . Arch Ophthal 77:61-66, 1967.Crossref 6. Bowers JF: Melanocytoma of the ciliary body . Arch Ophthal 71:649-652, 1964.Crossref 7. Scheie HG, Yanoff M: Pseudomelanoma of the ciliary body: Report of a patient . Arch Ophthal 77:81-83, 1967.Crossref 8. Thomas CI Purnell EW: Ocular melanocytoma . Amer J Ophthal 67:79-86, 1969. 9. Wessing A: Fluorescein Angiography of the Retina . St. Louis, CV Mosby Co, 1969. 10. Rosen ES: Fluorescence Photography of the Eye . New York, Appleton-Century-Crofts, 1969. 11. Shikano S, Shimizu K: Atlas of Fluorescence Fundus Angiography . Tokyo, Igaku Shoin, Ltd, 1968. 12. Norton EWD, Smith JL, Curtin VT, et al: Fluorescein fundus photography: An aid to the differential diagnosis of posterior ocular lesions . Trans Amer Acad Ophthal Otolaryng 68:755-765, 1964. 13. Pettit TH, Barton A, Foos RY, et al: Fluorescein angiography of choroidal melanomas . Arch Ophthal 83:27-38, 1970.Crossref 14. Snyder WB, Allen L, Frazier O: Fluorescence angiography of ocular tumors . Trans Amer Acad Ophthal Otolaryng 71:830-832, 1967. 15. Duke-Elder WS: Diseases of the uveal tract in System of Ophthalmology . St. Louis, CV Mosby Co, 1966, vol 9. 16. Reese AB: Tumors of the Eye . New York, Paul P Hoeber, 1951. 17. Dunphy EB, Forrest AW, Leopold IH, et al: The diagnosis and management of intraocular melanomas: A symposium . Trans Amer Acad Ophthal Otolaryng 62:517-555, 1958. 18. Naumann G, Zimmerman LE, Yanoff M: Visual field defect associated with choroidal nevus . Amer J Ophthal 62:914-917, 1966. 19. Flindall RJ, Drance SM: Visual field studies of benign choroidal melanomata . Arch Ophthal 81:41-44, 1969.Crossref 20. Naumann GOH, Hellner K, Naumann LR: Pigmented nevi of the choroid: Clinical study of secondary changes in the overlying tissues . Trans Amer Acad Ophthal Otolaryng 75:110-123, 1971. 21. Ferry AP: Lesions mistaken for malignant melanoma of the posterior uvea: A clinicopathologic analysis of 100 cases with ophthalmoscopically visible lesions . Arch Ophthal 72:463-469, 1964.Crossref 22. Zimmerman LE: Changing concepts concerning the malignancy of ocular tumors . Arch Ophthal 78:166-173, 1967.Crossref 23. Flocks M, Gerende JH, Zimmerman LE: The size and shape of malignant melanomas of the choroid and ciliary body in relation to the prognosis and histologic characteristics: A statistical study of 210 tumors . Trans Amer Acad Ophthal Otolaryng 59:740-758, 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Melanocytoma of the Choroid Clinically Simulating a Malignant Melanoma

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1972.01000020398006
Publisher site
See Article on Publisher Site

Abstract

Abstract A 46-year-old man was found on routine ophthalmoscopic examination to have a pigmented choroidal lesion that was suggestive of a malignant melanoma. Because of its clinical appearance, associated visual field defect, and the results of fluorescein angiography, the eye was enucleated. Histopathologically, the lesion proved to be a benign melanocytoma of the choroid. Although little is known about the fluorescein-angiographic characteristics of melanocytomas of the choroid, the fluorescein angiogram suggested a malignant melanoma. The advisability of a conservative approach to such small pigmented fundus lesions is reemphasized. References 1. Zimmerman LE, Garron LK: Melanocytoma of the optic disc . Int Ophthal Clin 2:431-440, 1962.Crossref 2. Zimmerman LE: Melanocytes, melanocytic nevi and melanocytomas . Invest Ophthal 4:11-41, 1965. 3. Naumann G, Yanoff M, Zimmerman LE: Histogenesis of malignant melanoma of the uvea: I. Histopathologic characteristics of nevi of the choroid and ciliary body . Arch Ophthal 76:784-796, 1966.Crossref 4. deVeer JA: Melanotic tumors of the optic nerve head: A pathologic study . Arch Ophthal 65:536-541, 1961.Crossref 5. Howard GM, Forrest AW: Incidence and location of melanocytomas . Arch Ophthal 77:61-66, 1967.Crossref 6. Bowers JF: Melanocytoma of the ciliary body . Arch Ophthal 71:649-652, 1964.Crossref 7. Scheie HG, Yanoff M: Pseudomelanoma of the ciliary body: Report of a patient . Arch Ophthal 77:81-83, 1967.Crossref 8. Thomas CI Purnell EW: Ocular melanocytoma . Amer J Ophthal 67:79-86, 1969. 9. Wessing A: Fluorescein Angiography of the Retina . St. Louis, CV Mosby Co, 1969. 10. Rosen ES: Fluorescence Photography of the Eye . New York, Appleton-Century-Crofts, 1969. 11. Shikano S, Shimizu K: Atlas of Fluorescence Fundus Angiography . Tokyo, Igaku Shoin, Ltd, 1968. 12. Norton EWD, Smith JL, Curtin VT, et al: Fluorescein fundus photography: An aid to the differential diagnosis of posterior ocular lesions . Trans Amer Acad Ophthal Otolaryng 68:755-765, 1964. 13. Pettit TH, Barton A, Foos RY, et al: Fluorescein angiography of choroidal melanomas . Arch Ophthal 83:27-38, 1970.Crossref 14. Snyder WB, Allen L, Frazier O: Fluorescence angiography of ocular tumors . Trans Amer Acad Ophthal Otolaryng 71:830-832, 1967. 15. Duke-Elder WS: Diseases of the uveal tract in System of Ophthalmology . St. Louis, CV Mosby Co, 1966, vol 9. 16. Reese AB: Tumors of the Eye . New York, Paul P Hoeber, 1951. 17. Dunphy EB, Forrest AW, Leopold IH, et al: The diagnosis and management of intraocular melanomas: A symposium . Trans Amer Acad Ophthal Otolaryng 62:517-555, 1958. 18. Naumann G, Zimmerman LE, Yanoff M: Visual field defect associated with choroidal nevus . Amer J Ophthal 62:914-917, 1966. 19. Flindall RJ, Drance SM: Visual field studies of benign choroidal melanomata . Arch Ophthal 81:41-44, 1969.Crossref 20. Naumann GOH, Hellner K, Naumann LR: Pigmented nevi of the choroid: Clinical study of secondary changes in the overlying tissues . Trans Amer Acad Ophthal Otolaryng 75:110-123, 1971. 21. Ferry AP: Lesions mistaken for malignant melanoma of the posterior uvea: A clinicopathologic analysis of 100 cases with ophthalmoscopically visible lesions . Arch Ophthal 72:463-469, 1964.Crossref 22. Zimmerman LE: Changing concepts concerning the malignancy of ocular tumors . Arch Ophthal 78:166-173, 1967.Crossref 23. Flocks M, Gerende JH, Zimmerman LE: The size and shape of malignant melanomas of the choroid and ciliary body in relation to the prognosis and histologic characteristics: A statistical study of 210 tumors . Trans Amer Acad Ophthal Otolaryng 59:740-758, 1955.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1972

References