Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Melanoacanthoma of the Lip

Melanoacanthoma of the Lip Abstract Melanoacanthoma is an extremely rare, benign, epidermal tumor characterized histologically by keratinocytes and numerous large, richly dendritic melanocytes. The majority of lesions are found on the head, neck, or upper extremities.1-3 A melanoacanthoma occurring on the lip has rarely, if ever, been reported. Report of a Case An 18-year-old black woman had had asymptomatic, hyperpigmented lesions on her upper lip for several months. The patient stated that her health was otherwise excellent. She denied taking any medications.Two black-brown, slightly raised, well-circumscribed plaques measuring 5 to 6 mm were present on the oral mucosa of the upper lip (Fig 1). There were no other abnormally pigmented lesions on the skin or mucous membranes.Hematoxylin-eosin sections of a biopsy specimen showed profuse numbers of dendritic melanocytes scattered throughout all levels of the acanthotic epidermis. Fontana's stain confirmed the presence of melanin within the melanocytes (Fig 2 and 3). Comment Melanoacanthomas References 1. Bloch B: Ueber benigne, nicht naevoide Melanoepitheliome der Haut nebst Bemerkungen über das Wesen und die Genese der Dendritenzellen . Arch Dermatol Syphilol 153:20-40, 1927.Crossref 2. Mishima Y, Pinkus H: Benign mixed tumor of melanocytes and Malpighian cells: Melanoacanthoma: Its relationship to Bloch's non-nevoid melanoepithelioma . Arch Dermatol 81:539-550, 1960.Crossref 3. Reaves CE: Melanoacanthoma: A case report and review of the literature . Bull Assoc Milit Dermatol 22:55-58, 1972. 4. Abulafia J, Grinspan D: Atypical melanoacanthoma . Med Cutan 3:125-130, 1968. 5. Rook A, Wilkinson DS, Ebling FJB: Textbook of Dermatology . Oxford, England, Blackwell Scientific Publications, 1972, p 1927. 6. Lever W, Schaumburg-Lever G: Histopathology of the Skin . Philadelphia, JB Lippincott Co, 1975, p 457. 7. Mevorah B, Mishima Y: Cellular response of seborrheic keratosis following croton oil irritation and surgical trauma . Dermatologica 131:452-464, 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Loading next page...
 
/lp/american-medical-association/melanoacanthoma-of-the-lip-3oghRc07T7
Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010090058027
Publisher site
See Article on Publisher Site

Abstract

Abstract Melanoacanthoma is an extremely rare, benign, epidermal tumor characterized histologically by keratinocytes and numerous large, richly dendritic melanocytes. The majority of lesions are found on the head, neck, or upper extremities.1-3 A melanoacanthoma occurring on the lip has rarely, if ever, been reported. Report of a Case An 18-year-old black woman had had asymptomatic, hyperpigmented lesions on her upper lip for several months. The patient stated that her health was otherwise excellent. She denied taking any medications.Two black-brown, slightly raised, well-circumscribed plaques measuring 5 to 6 mm were present on the oral mucosa of the upper lip (Fig 1). There were no other abnormally pigmented lesions on the skin or mucous membranes.Hematoxylin-eosin sections of a biopsy specimen showed profuse numbers of dendritic melanocytes scattered throughout all levels of the acanthotic epidermis. Fontana's stain confirmed the presence of melanin within the melanocytes (Fig 2 and 3). Comment Melanoacanthomas References 1. Bloch B: Ueber benigne, nicht naevoide Melanoepitheliome der Haut nebst Bemerkungen über das Wesen und die Genese der Dendritenzellen . Arch Dermatol Syphilol 153:20-40, 1927.Crossref 2. Mishima Y, Pinkus H: Benign mixed tumor of melanocytes and Malpighian cells: Melanoacanthoma: Its relationship to Bloch's non-nevoid melanoepithelioma . Arch Dermatol 81:539-550, 1960.Crossref 3. Reaves CE: Melanoacanthoma: A case report and review of the literature . Bull Assoc Milit Dermatol 22:55-58, 1972. 4. Abulafia J, Grinspan D: Atypical melanoacanthoma . Med Cutan 3:125-130, 1968. 5. Rook A, Wilkinson DS, Ebling FJB: Textbook of Dermatology . Oxford, England, Blackwell Scientific Publications, 1972, p 1927. 6. Lever W, Schaumburg-Lever G: Histopathology of the Skin . Philadelphia, JB Lippincott Co, 1975, p 457. 7. Mevorah B, Mishima Y: Cellular response of seborrheic keratosis following croton oil irritation and surgical trauma . Dermatologica 131:452-464, 1965.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1979

References