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Megaloblastic Anemia in Infancy and Childhood in Djakarta

Megaloblastic Anemia in Infancy and Childhood in Djakarta Abstract Since the publications on megaloblastic anemia in infants in 1946 by Zuelzer and Ogden in the United States1 and by Amato in Italy2 in 1947, many cases have been added.3-9 This disease seems to be not uncommon in childhood, especially with malnutrition or kwashiorkor10,11; sporadic cases have been described previously by several authors.12-17 Inasmuch as the diagnosis of megaloblastic anemia is based on the finding of megaloblasts in the bone marrow, our purpose was to determine the incidence of megaloblastic anemia in children admitted to our pediatric clinic during the last four years on whom bone marrow punctures were done. It was our purpose also to investigate the pathogenesis of megaloblastic anemia and the clinical symptoms in these children. Materials and Methods During the years 1954 to 1957, a total of 1,200 bone marrow punctures were done on 800 children for the following indications: Hemoglobin References 1. Zuelzer, W. W., and Ogden, F. N.: Megaloblastic Anemia in Infancy: A Common Syndrome Responding Specifically to Folic Acid Therapy , Am. J. Dis. Child. 71:211-243 ( (March) ) 1946.Crossref 2. Amato, M.: Tentativi di impiego terapeutico di dose unica massiva di estratto epatico nelle anemie megaloblastiche della prima infancia , Riv. clin. pediat. 45:53 ( (Jan.) ) 1947. 3. Aldrich, R. A., and Nelson, E. N.: Megaloblastic Anemia in Infants , Journal-Lancet 67:399-402 ( (Nov.) ) 1947. 4. Luhby, A., and Wheeler, W. E.: Megaloblastic Anemia of Infancy: II. Failure of Response to Vitamin B12 and the Metabolic Role of Folic Acid and Vitamin C , Health Center J. Ohio State Univ. 3:1, 1949. 5. Sturgeon, P., and Carpenter, G.: Megaloblastic Anemia of Infancy: Response to Vitamin B12 , Blood 5:458-467 ( (May) ) 1950. 6. Pecorella, F.; Burgio, G. R., and Aversa, T.: Osserviazioni cliniche ed etiopathogenetiche su 18 casi di anemie perniciosforme megaloblastica nel lattante , Riv. clin. pediat. 45:65-107 ( (Feb.) ) 1947. 7. Veeneklaas, G. M. H.: Megalocytic Deficiency Anemia Cured by Small Amounts of Fresh Endive , Arch. Dis. Childhood 27:209-213 ( (June) ) 1952.Crossref 8. Launay, C., and Bernard, J.: Anémie mégaloblastique grave due au lait de chévre: Echec de la vitamine B12; guérison par l'acide folique , Arch. franç. pédiat. 8:90-92, 1951. 9. Zuelzer, W. W., and Rutzky, J.: Megaloblastic Anemia of Infancy , Advances Pediat. 6:243, 1953. 10. Walt, F.; Holman, S., and Hendrickse, R. G.: Megaloblastic Anaemia of Infancy in Kwashiorkor and Other Diseases , Brit. M. J. 4977:1199-1203 ( (May 26) ) 1956.Crossref 11. Kho L-K.; Poesponegoro, S. F., and Poey S-H.: The Bone Marrow Picture of Kwashiorkor in Djakarta , Docum. med. geog. et trop. 9:69-83 ( (March) ) 1957. 12. Faber, H. K.: Value of Liver Extract (343) in Identifying and in Treating Certain Anemias of Infancy and of Childhood: Report of Case of Probable Primary Anemia in Infant 9½ Months Old , Am. J. Dis. Child. 36:1121-1135 ( (Dec.) ) 1928.Crossref 13. Parsons, L. G., and Hawksley, J. F.: Studies in Anaemias of Infancy and Early Childhood: Anhaematopoietic Anaemias (Deficiency Diseases of the Erythron), Nutritional Anaemia, and Anaemias of Prematurity, Scurvy and Coeliac Disease , Arch. Dis. Childhood 8:117-144 ( (April) ) 1933.Crossref 14. Parsons, L. G.: Studies in Anaemias of Infancy and Early Childhood: Introduction , Arch. Dis. Childhood 8:85-94 ( (April) ) 1933.Crossref 15. Bachman, A. L.: Macrocytic Hyperchromic Anemia in Early Infancy: Report of Case and Review of Literature , Am. J. Dis. Child. 52:633-647 ( (Sept.) ) 1936.Crossref 16. Veeneklaas, G. M. H.: Über megalozytare Mangelanamien bei Kleinkindern , Folia haemat. 65:303, 1942. 17. Davis, L. J.: Macrocytic Anaemia in Children, with a Report of 3 Cases Showing Megaloblastic Erythropoiesis , Arch. Dis. Childhood 19: 147-154 ( (Dec.) ) 1944.Crossref 18. Kho L-K.: Erythroblastopenia with Giant Pro-Erythroblasts in Kwashiorkor , Blood 12:171-182 ( (Feb.) ) 1957. 19. Trowell, H. C.: Dimorphic Anaemia: Deficiency of Iron Associated with Nutritional Macrocytic Anaemia , Tr. Roy. Soc. Trop. Med. & Hyg. 37:19-40 ( (July) ) 1943. 20. Poey S-H.: Kwashiorkor in Djakarta and Environments , Djakarta, Indonesia, University Press, 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Megaloblastic Anemia in Infancy and Childhood in Djakarta

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1959.02070010211010
Publisher site
See Article on Publisher Site

Abstract

Abstract Since the publications on megaloblastic anemia in infants in 1946 by Zuelzer and Ogden in the United States1 and by Amato in Italy2 in 1947, many cases have been added.3-9 This disease seems to be not uncommon in childhood, especially with malnutrition or kwashiorkor10,11; sporadic cases have been described previously by several authors.12-17 Inasmuch as the diagnosis of megaloblastic anemia is based on the finding of megaloblasts in the bone marrow, our purpose was to determine the incidence of megaloblastic anemia in children admitted to our pediatric clinic during the last four years on whom bone marrow punctures were done. It was our purpose also to investigate the pathogenesis of megaloblastic anemia and the clinical symptoms in these children. Materials and Methods During the years 1954 to 1957, a total of 1,200 bone marrow punctures were done on 800 children for the following indications: Hemoglobin References 1. Zuelzer, W. W., and Ogden, F. N.: Megaloblastic Anemia in Infancy: A Common Syndrome Responding Specifically to Folic Acid Therapy , Am. J. Dis. Child. 71:211-243 ( (March) ) 1946.Crossref 2. Amato, M.: Tentativi di impiego terapeutico di dose unica massiva di estratto epatico nelle anemie megaloblastiche della prima infancia , Riv. clin. pediat. 45:53 ( (Jan.) ) 1947. 3. Aldrich, R. A., and Nelson, E. N.: Megaloblastic Anemia in Infants , Journal-Lancet 67:399-402 ( (Nov.) ) 1947. 4. Luhby, A., and Wheeler, W. E.: Megaloblastic Anemia of Infancy: II. Failure of Response to Vitamin B12 and the Metabolic Role of Folic Acid and Vitamin C , Health Center J. Ohio State Univ. 3:1, 1949. 5. Sturgeon, P., and Carpenter, G.: Megaloblastic Anemia of Infancy: Response to Vitamin B12 , Blood 5:458-467 ( (May) ) 1950. 6. Pecorella, F.; Burgio, G. R., and Aversa, T.: Osserviazioni cliniche ed etiopathogenetiche su 18 casi di anemie perniciosforme megaloblastica nel lattante , Riv. clin. pediat. 45:65-107 ( (Feb.) ) 1947. 7. Veeneklaas, G. M. H.: Megalocytic Deficiency Anemia Cured by Small Amounts of Fresh Endive , Arch. Dis. Childhood 27:209-213 ( (June) ) 1952.Crossref 8. Launay, C., and Bernard, J.: Anémie mégaloblastique grave due au lait de chévre: Echec de la vitamine B12; guérison par l'acide folique , Arch. franç. pédiat. 8:90-92, 1951. 9. Zuelzer, W. W., and Rutzky, J.: Megaloblastic Anemia of Infancy , Advances Pediat. 6:243, 1953. 10. Walt, F.; Holman, S., and Hendrickse, R. G.: Megaloblastic Anaemia of Infancy in Kwashiorkor and Other Diseases , Brit. M. J. 4977:1199-1203 ( (May 26) ) 1956.Crossref 11. Kho L-K.; Poesponegoro, S. F., and Poey S-H.: The Bone Marrow Picture of Kwashiorkor in Djakarta , Docum. med. geog. et trop. 9:69-83 ( (March) ) 1957. 12. Faber, H. K.: Value of Liver Extract (343) in Identifying and in Treating Certain Anemias of Infancy and of Childhood: Report of Case of Probable Primary Anemia in Infant 9½ Months Old , Am. J. Dis. Child. 36:1121-1135 ( (Dec.) ) 1928.Crossref 13. Parsons, L. G., and Hawksley, J. F.: Studies in Anaemias of Infancy and Early Childhood: Anhaematopoietic Anaemias (Deficiency Diseases of the Erythron), Nutritional Anaemia, and Anaemias of Prematurity, Scurvy and Coeliac Disease , Arch. Dis. Childhood 8:117-144 ( (April) ) 1933.Crossref 14. Parsons, L. G.: Studies in Anaemias of Infancy and Early Childhood: Introduction , Arch. Dis. Childhood 8:85-94 ( (April) ) 1933.Crossref 15. Bachman, A. L.: Macrocytic Hyperchromic Anemia in Early Infancy: Report of Case and Review of Literature , Am. J. Dis. Child. 52:633-647 ( (Sept.) ) 1936.Crossref 16. Veeneklaas, G. M. H.: Über megalozytare Mangelanamien bei Kleinkindern , Folia haemat. 65:303, 1942. 17. Davis, L. J.: Macrocytic Anaemia in Children, with a Report of 3 Cases Showing Megaloblastic Erythropoiesis , Arch. Dis. Childhood 19: 147-154 ( (Dec.) ) 1944.Crossref 18. Kho L-K.: Erythroblastopenia with Giant Pro-Erythroblasts in Kwashiorkor , Blood 12:171-182 ( (Feb.) ) 1957. 19. Trowell, H. C.: Dimorphic Anaemia: Deficiency of Iron Associated with Nutritional Macrocytic Anaemia , Tr. Roy. Soc. Trop. Med. & Hyg. 37:19-40 ( (July) ) 1943. 20. Poey S-H.: Kwashiorkor in Djakarta and Environments , Djakarta, Indonesia, University Press, 1957.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1959

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