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- Publisher
- American Medical Association
- Copyright
- Copyright © 1976 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.1976.03270120003001
- Publisher site
- See Article on Publisher Site
Abstract
`Associated agent,' lymphotoxin among clues to multiple sclerosis More and more tantalizing clues are accumulating as increasingly sophisticated research probes the mystery of multiple sclerosis. In the East, investigators in Philadelphia have extended earlier work by others, indicating that serum and brain tissue from multiple sclerosis patients can harbor a "multiple sclerosis-associated agent," apparently a virus. In the West, researchers at the University of California, Irvine, College of Medicine are purifying and characterizing a "lymphotoxic factor" from the serum of multiple sclerosis patients. Both the multiple sclerosis-associated agent and the lymphotoxic factor seem to be easier to detect during periods when the disease is exacerbated. The Eastern investigators are Werner Henle, MD; Paul Koldovsky, MD, PhD; Ursula Koldovsky, PhD; Gertrude Henle, MD; Rudolf Ackermann, PhD; and Gunter Haase, MD, working at the Joseph Stokes Jr Research Institute, Children's Hospital of Philadelphia, and the University of Pennsylvania School of Medicine.
Journal
JAMA – American Medical Association
Published: Sep 13, 1976