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Medical Management of Genital Herpes: Advances in Antiviral Treatment

Medical Management of Genital Herpes: Advances in Antiviral Treatment Abstract It is estimated that 5 to 20 million persons in the United States have genital herpes, with 260,000 to 500,000 new cases occurring each year. The need for effective agents for treatment, prevention, and cure is obvious, but the psychosocial morbidity associated with genital herpes infections is less well appreciated. A new era in the treatment of genital herpes infections has begun with the advent of effective antiviral chemotherapy. Physicians have been frustrated by a lack of specific therapy for this trouble some and sometimes devastating skin disease for centuries. In his excellent review and clinical classification of herpes skin infections, Ferdinand Hebra1 in 1866 took the following position in response to the toxic treatments popular in his day: "the fact... herpes terminates within a tolerably short time is sufficient to show that any special treatment of this disease is unnecessary." He goes on to say, "Experience, then, teaches that an expectant treatment is References 1. Hebra F: Treatment of herpes , in On Diseases of the Skin . London, The New Sydenham Society, 1869, vol 1, p 382. 2. Kaposi M: Lecture XIX , in Pathology and Treatment of Diseases of the Skin . New York, William Wood and Co, 1895, p 251. 3. Luby ED, Klinge V: Genital herpes: A pervasive psychosocial disorder . Arch Dermatol 1985;121:494-497.Crossref 4. Richman D, Schmidt N, Plotkin S; et al: Summary of a workshop on new and useful methods in rapid viral diagnosis . J Infect Dis 1984;150:941-951.Crossref 5. Casey S, Crumpacker C: Direct diagnosis of HSV-1 and HSV-2 infection by immunofluorescence employing viral specific monoclonal antibodies, abstract 360 . Program and abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, Oct 8-10, 1984 . 6. Redfield DC, Richman DD, Albanil S, et al: Detection of herpes simplex virus in clinical specimens by DNA hybridization . Diagn Microbiol Infect Dis 1983;1:117-128.Crossref 7. Bernstein DI, Lovett MA, Bryson YJ: Serologic analysis of first-episode nonprimary genital herpes simplex virus infections . Am J Med 1984;77:1055-1060.Crossref 8. Corey L, Fife KH, Benedetti JK, et al: Intravenous acyclovir for the treatment of primary genital herpes . Ann Intern Med 1983;98:914-921.Crossref 9. Bryson YJ, Dillon M, Lovett M, et al: Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir . N Engl J Med 1983;308:916.Crossref 10. Nilsen AE, Aasen R, Halsos AM, et al: Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes . Lancet 1982;2:571-573.Crossref 11. Corey L, Nahmias AJ, Guinan ME, et al: A trial of topical acyclovir in genital herpes simplex virus infections . N Engl J Med 1982;306:1313-1319.Crossref 12. Reichman RC, Badger GJ, Guinan ME, et al: Topically administered acyclovir in the treatment of recurrent herpes simplex infection: A controlled trial . J Infect Dis 1983;147:336-340.Crossref 13. Luby JP, Gnann JW, Alexander WJ, et al: A collaborative study of patient-initiated treatment of recurrent genital herpes with topical acyclovir or placebo . J Infect Dis 1984;150:1-6.Crossref 14. Reichman RC, Badger GJ, Mertz GJ, et al: Treatment of recurrent genital herpes simplex infections with oral acyclovir . JAMA 1984;251:2103-2107.Crossref 15. Douglas JM, Critchlow C, Benedetti J, et al: A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection . N Engl J Med 1984;310:1551-1556.Crossref 16. Straus SE, Takiff HE, Seidlin M, et al: Suppression of frequently recurring genital herpes: A placebo-controlled doubleblind trial of oral acyclovir . N Engl J Med 1984;310:1546-1550.Crossref 17. Mindel A, Faherty A, Hindley D, et al: Prophylactic oral acyclovir in recurrent genital herpes . Lancet 1984;2:57-59.Crossref 18. Crumpacker C: Resistance of herpes simplex virus to antiviral agents: Is it clinically important? Drugs 1983;26:373-377.Crossref 19. Parris DS, Harrington JE: Herpes simplex virus variants resistant to high concentrations of acyclovir exist in clinical isolates . Antimicrob Agents Chemother 1982;22:71-77.Crossref 20. Ellis MN, Keller PM, Straus SE, et al: Characterization of an HSV-2 clinical isolate containing an ACV-resistant mutant which produces a thymidine kinase with altered substrate specificity . Programs and abstracts of the Ninth International Herpesvirus Workshop, Seattle, Aug 24-29, 1984 . 21. Field HJ, Anderson J, Wildy P: Atypical patterns of neural infection in mice by drug resistant strains of herpes simplex virus . J Gen Virol 1982;59:91-99.Crossref 22. McLaren C, Corey L, Dekket C, et al: In vitro sensitivity to acyclovir in gential herpes simplex viruses from acyclovir-treated patients . J Infect Dis 1983;148:868-875.Crossref 23. Marlowe S, Kowalsky P, Schnipper L, et al: Sensitivity of HSV clinical isolates after topical and intravenous acyclovir and correlation with a plaque autoradiography method for the identification of HSV TK- mutants, abstract 568 . Programs and abstracts of the 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas, Oct 24-26, 1983 . 24. Marlowe S, Douglas J, Corey L, et al: Sensitivity of HSV genital isolates after oral acyclovir, abstract 1253 . Programs and abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, Oct 8-10, 1984 . 25. Corey L, Holmes KK: Genital herpes simplex virus infections: Current concepts in diagnosis, therapy and prevention . Ann Intern Med 1983;98:973-983.Crossref 26. Bierman SM, Kirkpatrick W, Fernandez H: Clinical efficacy of ribavirin in the treatment of genital herpes simplex virus infection . Chemotherapy 1981;27:139-145.Crossref 27. Pazin GJ, Armstrong JA, Lam MT, et al: Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root . N Engl J Med 1978;301:225-230.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Medical Management of Genital Herpes: Advances in Antiviral Treatment

Archives of Dermatology , Volume 121 (4) – Apr 1, 1985

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660040051010
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Abstract

Abstract It is estimated that 5 to 20 million persons in the United States have genital herpes, with 260,000 to 500,000 new cases occurring each year. The need for effective agents for treatment, prevention, and cure is obvious, but the psychosocial morbidity associated with genital herpes infections is less well appreciated. A new era in the treatment of genital herpes infections has begun with the advent of effective antiviral chemotherapy. Physicians have been frustrated by a lack of specific therapy for this trouble some and sometimes devastating skin disease for centuries. In his excellent review and clinical classification of herpes skin infections, Ferdinand Hebra1 in 1866 took the following position in response to the toxic treatments popular in his day: "the fact... herpes terminates within a tolerably short time is sufficient to show that any special treatment of this disease is unnecessary." He goes on to say, "Experience, then, teaches that an expectant treatment is References 1. Hebra F: Treatment of herpes , in On Diseases of the Skin . London, The New Sydenham Society, 1869, vol 1, p 382. 2. Kaposi M: Lecture XIX , in Pathology and Treatment of Diseases of the Skin . New York, William Wood and Co, 1895, p 251. 3. Luby ED, Klinge V: Genital herpes: A pervasive psychosocial disorder . Arch Dermatol 1985;121:494-497.Crossref 4. Richman D, Schmidt N, Plotkin S; et al: Summary of a workshop on new and useful methods in rapid viral diagnosis . J Infect Dis 1984;150:941-951.Crossref 5. Casey S, Crumpacker C: Direct diagnosis of HSV-1 and HSV-2 infection by immunofluorescence employing viral specific monoclonal antibodies, abstract 360 . Program and abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, Oct 8-10, 1984 . 6. Redfield DC, Richman DD, Albanil S, et al: Detection of herpes simplex virus in clinical specimens by DNA hybridization . Diagn Microbiol Infect Dis 1983;1:117-128.Crossref 7. Bernstein DI, Lovett MA, Bryson YJ: Serologic analysis of first-episode nonprimary genital herpes simplex virus infections . Am J Med 1984;77:1055-1060.Crossref 8. Corey L, Fife KH, Benedetti JK, et al: Intravenous acyclovir for the treatment of primary genital herpes . Ann Intern Med 1983;98:914-921.Crossref 9. Bryson YJ, Dillon M, Lovett M, et al: Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir . N Engl J Med 1983;308:916.Crossref 10. Nilsen AE, Aasen R, Halsos AM, et al: Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes . Lancet 1982;2:571-573.Crossref 11. Corey L, Nahmias AJ, Guinan ME, et al: A trial of topical acyclovir in genital herpes simplex virus infections . N Engl J Med 1982;306:1313-1319.Crossref 12. Reichman RC, Badger GJ, Guinan ME, et al: Topically administered acyclovir in the treatment of recurrent herpes simplex infection: A controlled trial . J Infect Dis 1983;147:336-340.Crossref 13. Luby JP, Gnann JW, Alexander WJ, et al: A collaborative study of patient-initiated treatment of recurrent genital herpes with topical acyclovir or placebo . J Infect Dis 1984;150:1-6.Crossref 14. Reichman RC, Badger GJ, Mertz GJ, et al: Treatment of recurrent genital herpes simplex infections with oral acyclovir . JAMA 1984;251:2103-2107.Crossref 15. Douglas JM, Critchlow C, Benedetti J, et al: A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection . N Engl J Med 1984;310:1551-1556.Crossref 16. Straus SE, Takiff HE, Seidlin M, et al: Suppression of frequently recurring genital herpes: A placebo-controlled doubleblind trial of oral acyclovir . N Engl J Med 1984;310:1546-1550.Crossref 17. Mindel A, Faherty A, Hindley D, et al: Prophylactic oral acyclovir in recurrent genital herpes . Lancet 1984;2:57-59.Crossref 18. Crumpacker C: Resistance of herpes simplex virus to antiviral agents: Is it clinically important? Drugs 1983;26:373-377.Crossref 19. Parris DS, Harrington JE: Herpes simplex virus variants resistant to high concentrations of acyclovir exist in clinical isolates . Antimicrob Agents Chemother 1982;22:71-77.Crossref 20. Ellis MN, Keller PM, Straus SE, et al: Characterization of an HSV-2 clinical isolate containing an ACV-resistant mutant which produces a thymidine kinase with altered substrate specificity . Programs and abstracts of the Ninth International Herpesvirus Workshop, Seattle, Aug 24-29, 1984 . 21. Field HJ, Anderson J, Wildy P: Atypical patterns of neural infection in mice by drug resistant strains of herpes simplex virus . J Gen Virol 1982;59:91-99.Crossref 22. McLaren C, Corey L, Dekket C, et al: In vitro sensitivity to acyclovir in gential herpes simplex viruses from acyclovir-treated patients . J Infect Dis 1983;148:868-875.Crossref 23. Marlowe S, Kowalsky P, Schnipper L, et al: Sensitivity of HSV clinical isolates after topical and intravenous acyclovir and correlation with a plaque autoradiography method for the identification of HSV TK- mutants, abstract 568 . Programs and abstracts of the 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas, Oct 24-26, 1983 . 24. Marlowe S, Douglas J, Corey L, et al: Sensitivity of HSV genital isolates after oral acyclovir, abstract 1253 . Programs and abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, Oct 8-10, 1984 . 25. Corey L, Holmes KK: Genital herpes simplex virus infections: Current concepts in diagnosis, therapy and prevention . Ann Intern Med 1983;98:973-983.Crossref 26. Bierman SM, Kirkpatrick W, Fernandez H: Clinical efficacy of ribavirin in the treatment of genital herpes simplex virus infection . Chemotherapy 1981;27:139-145.Crossref 27. Pazin GJ, Armstrong JA, Lam MT, et al: Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root . N Engl J Med 1978;301:225-230.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1985

References