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References (6)
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H. Popper (1958)
Liver: Structure and FunctionDiabetes, 7
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M. Mills, C. Dragstedt (1938)
REMOVAL OF INTRAVENOUSLY INJECTED BROMSULPHALEIN FROM THE BLOOD STREAM OF THE DOG: A COMPARISON OF THE REMOVAL OF INTRAVENOUSLY INJECTED BILIRUBIN AND THAT OF BROMSULPHALEINJAMA Internal Medicine, 62
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D. Cook, C. Lawler, L. Calvin, D. Green (1952)
Mechanisms of bile formation.The American journal of physiology, 171 1
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R. Brauer, R. Pessotti, J. Krebs (1955)
The distribution and excretion of S35-labeled sulfobromophthalein-sodium administered to dogs by continuous infusion.The Journal of clinical investigation, 34 1
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W. Andrews, B. Maegraith, T. Richards (1956)
The effect upon bromsulphalein extraction of the rate and distribution of blood flow in the perfused canine liverThe Journal of Physiology, 131
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R. Brauer, G. Leong, R. Holloway (1954)
Mechanics of bile secretion; effect of perfusion pressure and temperature on bile flow and bile secretion pressure.The American journal of physiology, 177 1
- Publisher
- American Medical Association
- Copyright
- Copyright © 1959 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.1959.03000300058011
- Publisher site
- See Article on Publisher Site
Abstract
The formation of bile in the liver is a complicated process. One group (A) of substances appears in bile in the same concentrations as in blood; this includes glucose and the chlorides of sodium and potassium. A second group (B) appears in bile concentrated as much as hundredfold; this group includes the bile salts, bile pigments, and certain test substances like sulfobromophthalein. A third group (C) is retained in the blood and appears in the bile only in very low concentrations, if at all. Groups A and B are controlled independently of each other, and substances of group B are transferred from blood to bile by an active secretory process. The transfer of sulfobromophthalein involves some active secretion, some storage, and some chemical conversion with other phenomena in addition. Since better understanding of these processes is essential to the interpretation of functional tests and the planning of treatment, further fundamental research is needed.
Journal
JAMA – American Medical Association
Published: Mar 28, 1959