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EPIDEMIOLOGY SECTION EDITOR: LESLIE HYMAN, PhD Measuring Refraction in Adults in Epidemiological Studies Elizabeth M. Krantz, MS; Karen J. Cruickshanks, PhD; Barbara E. K. Klein, MD; Ronald Klein, MD; Guan-Hua Huang, PhD; F. Javier Nieto, PhD Objective: To compare refraction measured before and Results: The mean age was 48 years (range, 22-84 years). after pharmacologic cycloplegia. The mean difference in SE between measurements before and after cycloplegia was 0.29 D (95% confidence inter- val, 0.28-0.31). The difference decreased with age and var- Methods: This study used preliminary data from the Bea- ied by refractive status for participants younger than 50 ver Dam Offspring Study, which includes adult children years, with the largest differences observed among young of participants in the population-based Epidemiology of persons with hyperopic refractive errors. Across all age Hearing Loss Study of older adults living in Beaver Dam, groups, agreement on classifications of refraction was high Wisconsin. Data were available for 5018 eyes of 2529 par- (84%-92%). ticipants. Refraction was defined by the spherical equiva- lent (SE), using autorefractor readings. Differences were Conclusions: Overall, clinically inconsequential differences calculated as the SE after drops were administered minus were observed between SEs before and after pharmacologic the SE
JAMA Ophthalmology – American Medical Association
Published: Jan 1, 2010
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