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Measurement of Blood-Retinal Barrier Function in Central Retinal Vein Occlusion

Measurement of Blood-Retinal Barrier Function in Central Retinal Vein Occlusion Abstract • Vitreous fluorophotometry was used to measure blood-retinal barrier permeability to fluorescein in eight patients (mean age, 42.9 years; range, 30 to 55 years) with central retinal vein occlusion (CRVO). Permeability coefficient was derived by fitting a mathematical model to the posterior vitreous fluorescence scan and plasma-free fluorescein concentration curve at 60 minutes after intravenous fluorescein sodium (14 mg · kg-1). A permeability index (PI) was estimated by dividing the area under the vitreous fluorescence scan by the area under the plasma-free fluorescein curve. The permeability coefficient and PI were comparable and highly correlated. Initial mean permeability coefficient was 28.78 × 10-7 cm · S-1 (range, 14.42 × 10-7 to 41.10 × 10-7) and 1.89 × 10-7 cm · s-2 (range, 0.96 × 10-7 to 2.76 × 10-7) in eight affected and seven unaffected eyes, respectively. The permeability coefficient and PI in unaffected eyes did not differ significantly from 18 eyes of ten normal subjects. After three to 12 months, permeability coefficient and PI in affected eyes approached the values in the contralateral eyes of four patients with mild and one patient with moderate CRVO but remained elevated in the remaining patients. The permeability coefficient and PI correlated well with changes in severity of retinal appearances on color photographs and fluorescein angiograms. Vitreous fluorophotometry quantitated changes in blood-retinal barrier permeability in CRVO. References 1. Cunha-Vaz JG: Site and function of the blood-retinal barriers , in Cunha-Vaz JG (ed): The Blood-Retinal Barriers . New York, Plenum Publishing Corp, 1980, pp 101-107. 2. Chahal P, Chowienczyk PJ, Kohner EM: Measurement of blood-retinal barrier permeability: A reproducibility study in normal eyes . Invest Ophthalmol Vis Sci 1985;26:977-982. 3. Zeimer RC, Blair NP, Cunha-Vaz JG: Vitreous fluorophotometry for clinical research: I. Description and evaluation of a new fluorophotometer . Arch Ophthalmol 1983;101:1753-1756.Crossref 4. Zeimer RC, Blair NP, Cunha-Vaz JG: Vitreous fluorophotometry for clinical research: II. Method of data acquisition and processing . Arch Ophthalmol 1983;101:1757-1761.Crossref 5. Chahal P, Neal M, Kohner EM: Rapid metabolism of fluorescein after intravenous administration . Invest Ophthalmol Vis Sci 1985; 26:764-768. 6. Larsen J, Lund-Anderson H, Krogsaa B: Transient transport across the blood-retinal barrier . Bull Math Biol 1983;45:749-759.Crossref 7. Kohner EM, Shilling JS: Retinal vein occlusion , in Rose FC (ed): Medical Ophthalmology . London, Chapman & Hall Ltd, 1976, pp 391-430. 8. Hayreh SS: Classification of central retinal vein occlusion . Ophthalmology 1983;90:458-474.Crossref 9. Williams BI, Gordon D, Peart WS: Abnormal variability of intraocular pressure and systemic arterial blood pressure in diabetes, hyper-tension, and retinal vein occlusion . Lancet 1981; 2:1255-1257.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Measurement of Blood-Retinal Barrier Function in Central Retinal Vein Occlusion

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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1986.01050160110024
Publisher site
See Article on Publisher Site

Abstract

Abstract • Vitreous fluorophotometry was used to measure blood-retinal barrier permeability to fluorescein in eight patients (mean age, 42.9 years; range, 30 to 55 years) with central retinal vein occlusion (CRVO). Permeability coefficient was derived by fitting a mathematical model to the posterior vitreous fluorescence scan and plasma-free fluorescein concentration curve at 60 minutes after intravenous fluorescein sodium (14 mg · kg-1). A permeability index (PI) was estimated by dividing the area under the vitreous fluorescence scan by the area under the plasma-free fluorescein curve. The permeability coefficient and PI were comparable and highly correlated. Initial mean permeability coefficient was 28.78 × 10-7 cm · S-1 (range, 14.42 × 10-7 to 41.10 × 10-7) and 1.89 × 10-7 cm · s-2 (range, 0.96 × 10-7 to 2.76 × 10-7) in eight affected and seven unaffected eyes, respectively. The permeability coefficient and PI in unaffected eyes did not differ significantly from 18 eyes of ten normal subjects. After three to 12 months, permeability coefficient and PI in affected eyes approached the values in the contralateral eyes of four patients with mild and one patient with moderate CRVO but remained elevated in the remaining patients. The permeability coefficient and PI correlated well with changes in severity of retinal appearances on color photographs and fluorescein angiograms. Vitreous fluorophotometry quantitated changes in blood-retinal barrier permeability in CRVO. References 1. Cunha-Vaz JG: Site and function of the blood-retinal barriers , in Cunha-Vaz JG (ed): The Blood-Retinal Barriers . New York, Plenum Publishing Corp, 1980, pp 101-107. 2. Chahal P, Chowienczyk PJ, Kohner EM: Measurement of blood-retinal barrier permeability: A reproducibility study in normal eyes . Invest Ophthalmol Vis Sci 1985;26:977-982. 3. Zeimer RC, Blair NP, Cunha-Vaz JG: Vitreous fluorophotometry for clinical research: I. Description and evaluation of a new fluorophotometer . Arch Ophthalmol 1983;101:1753-1756.Crossref 4. Zeimer RC, Blair NP, Cunha-Vaz JG: Vitreous fluorophotometry for clinical research: II. Method of data acquisition and processing . Arch Ophthalmol 1983;101:1757-1761.Crossref 5. Chahal P, Neal M, Kohner EM: Rapid metabolism of fluorescein after intravenous administration . Invest Ophthalmol Vis Sci 1985; 26:764-768. 6. Larsen J, Lund-Anderson H, Krogsaa B: Transient transport across the blood-retinal barrier . Bull Math Biol 1983;45:749-759.Crossref 7. Kohner EM, Shilling JS: Retinal vein occlusion , in Rose FC (ed): Medical Ophthalmology . London, Chapman & Hall Ltd, 1976, pp 391-430. 8. Hayreh SS: Classification of central retinal vein occlusion . Ophthalmology 1983;90:458-474.Crossref 9. Williams BI, Gordon D, Peart WS: Abnormal variability of intraocular pressure and systemic arterial blood pressure in diabetes, hyper-tension, and retinal vein occlusion . Lancet 1981; 2:1255-1257.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1986

References