REVIEW Maternal Overweight and Obesity and the Risk of Congenital Anomalies A Systematic Review and Meta-analysis Katherine J. Stothard, PhD Context Evidence suggests an association between maternal obesity and some con- Peter W. G. Tennant, MSc genital anomalies. Ruth Bell, MD Objective To assess current evidence of the association between maternal over- weight, maternal obesity, and congenital anomaly. Judith Rankin, PhD Data Sources MEDLINE, EMBASE, CINAHL, and Scopus ( January 1966 through May 2008) were searched for English-language studies using a list of keywords. Reference BESITY IS A MAJOR PUBLIC lists from relevant review articles were also searched. health and economic con- Study Selection Observational studies with an estimate of prepregnancy or early cern. Worldwide, an esti- pregnancy weight or body mass index (BMI) and data on congenital anomalies were Omated 1.6 billion adults considered. Of 1944 potential articles, 39 were included in the systematic review and (aged 15 years and older) were over- 18 in the meta-analysis. weight (body mass index [BMI] Data Extraction and Synthesis Information was extracted on study design, 25-30, calculated as weight in kilo- quality, participants, congenital anomaly groups and subtypes, and risk estimates. grams divided by height in meters Pooled odds ratios (ORs)
JAMA – American Medical Association
Published: Feb 11, 2009
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