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Maternal Influenza Vaccination and Effect on Influenza Virus Infection in Young Infants

Maternal Influenza Vaccination and Effect on Influenza Virus Infection in Young Infants ARTICLE ONLINE FIRST Maternal Influenza Vaccination and Effect on Influenza Virus Infection in Young Infants Angelia A. Eick, PhD; Timothy M. Uyeki, MD, MPH, MPP; Alexander Klimov, PhD; Henrietta Hall, MS; Raymond Reid, MD; Mathuram Santosham, MD; Katherine L. O’Brien, MD, MPH Objective: To assess the effect of seasonal influenza vac- had only an ILI outpatient visit, and 555 (48%) had no cination during pregnancy on laboratory-confirmed in- ILI episodes. The ILI incidence rate was 7.2 and 6.7 per fluenza in infants to 6 months of age. 1000 person-days for infants born to unvaccinated and vaccinated women, respectively. There was a 41% re- Design: Nonrandomized, prospective, observational duction in the risk of laboratory-confirmed influenza vi- cohort study. rus infection (relative risk, 0.59; 95% confidence inter- val, 0.37-0.93) and a 39% reduction in the risk of ILI Setting: Navajo and White Mountain Apache Indian res- hospitalization (relative risk, 0.61; 95% confidence ervations, including 6 hospitals on the Navajo reserva- interval, 0.45-0.84) for infants born to influenza- tion and 1 on the White Mountain Apache reservation. vaccinated women compared with infants born to unvaccinated mothers. Infants born to influenza- Participants: A total of 1169 mother-infant pairs with vaccinated women had significantly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Maternal Influenza Vaccination and Effect on Influenza Virus Infection in Young Infants

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2010.192
pmid
20921345
Publisher site
See Article on Publisher Site

Abstract

ARTICLE ONLINE FIRST Maternal Influenza Vaccination and Effect on Influenza Virus Infection in Young Infants Angelia A. Eick, PhD; Timothy M. Uyeki, MD, MPH, MPP; Alexander Klimov, PhD; Henrietta Hall, MS; Raymond Reid, MD; Mathuram Santosham, MD; Katherine L. O’Brien, MD, MPH Objective: To assess the effect of seasonal influenza vac- had only an ILI outpatient visit, and 555 (48%) had no cination during pregnancy on laboratory-confirmed in- ILI episodes. The ILI incidence rate was 7.2 and 6.7 per fluenza in infants to 6 months of age. 1000 person-days for infants born to unvaccinated and vaccinated women, respectively. There was a 41% re- Design: Nonrandomized, prospective, observational duction in the risk of laboratory-confirmed influenza vi- cohort study. rus infection (relative risk, 0.59; 95% confidence inter- val, 0.37-0.93) and a 39% reduction in the risk of ILI Setting: Navajo and White Mountain Apache Indian res- hospitalization (relative risk, 0.61; 95% confidence ervations, including 6 hospitals on the Navajo reserva- interval, 0.45-0.84) for infants born to influenza- tion and 1 on the White Mountain Apache reservation. vaccinated women compared with infants born to unvaccinated mothers. Infants born to influenza- Participants: A total of 1169 mother-infant pairs with vaccinated women had significantly

Journal

JAMA PediatricsAmerican Medical Association

Published: Feb 1, 2011

References