Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Massive Doses of Vitamin B12 in Treatment of Schizophrenia

Massive Doses of Vitamin B12 in Treatment of Schizophrenia Abstract During the past few years vitamin B12 has been used successfully in the treatment of various disorders of the nervous system, especially various painful neuropathies. When solutions of greater potency became available, it was found that doses of 1000γ daily would relieve the pain in many cases of trigeminal neuralgia. The exact mode of action is obscure, but it does not appear to be on a simple replacement basis.1 An effect on the "deranged intrinsic nerve metabolism" has been suggested.3 Because of these encouraging reports, it was decided to try massive doses of vitamin B12 in treatment of schizophrenic patients, who might also be said to have an obscure disorder of the nervous system. Since the medication appears to have no harmful effects, this was considered to be a sufficient indication for such a clinical trial. METHOD Twenty patients diagnosed as showing schizophrenic reactions were References 1. The Vitamin B12 for this study was supplied by Merck & Company, Inc. 2. Fields, W. S., and Hoff, H. E.: Relief of Pain in Trigeminal Neuralgia by Crystalline Vitamin B12 , Neurology 2:131-139 ( (March-April) ) 1952.Crossref 3. Surtees, S. J., and Hughes, R. R.: Treatment of Trigeminal Neuralgia with Vitamin B12 , Lancet 1:439-441 ( (Feb. 27) ) 1954.Crossref 4. Sancetta, S. M.; Ayres, P. R., and Scott, R. W.: Use of Vitamin B12 in the Management of the Neurologic Manifestations of Diabetes Mellitus, with Notes on the Administration of Massive Doses , Ann. Int. Med. 35:1028-1048 ( (Nov.) ) 1951.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Massive Doses of Vitamin B12 in Treatment of Schizophrenia

Loading next page...
 
/lp/american-medical-association/massive-doses-of-vitamin-b12-in-treatment-of-schizophrenia-askJ103dqp
Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1955.02330090091012
Publisher site
See Article on Publisher Site

Abstract

Abstract During the past few years vitamin B12 has been used successfully in the treatment of various disorders of the nervous system, especially various painful neuropathies. When solutions of greater potency became available, it was found that doses of 1000γ daily would relieve the pain in many cases of trigeminal neuralgia. The exact mode of action is obscure, but it does not appear to be on a simple replacement basis.1 An effect on the "deranged intrinsic nerve metabolism" has been suggested.3 Because of these encouraging reports, it was decided to try massive doses of vitamin B12 in treatment of schizophrenic patients, who might also be said to have an obscure disorder of the nervous system. Since the medication appears to have no harmful effects, this was considered to be a sufficient indication for such a clinical trial. METHOD Twenty patients diagnosed as showing schizophrenic reactions were References 1. The Vitamin B12 for this study was supplied by Merck & Company, Inc. 2. Fields, W. S., and Hoff, H. E.: Relief of Pain in Trigeminal Neuralgia by Crystalline Vitamin B12 , Neurology 2:131-139 ( (March-April) ) 1952.Crossref 3. Surtees, S. J., and Hughes, R. R.: Treatment of Trigeminal Neuralgia with Vitamin B12 , Lancet 1:439-441 ( (Feb. 27) ) 1954.Crossref 4. Sancetta, S. M.; Ayres, P. R., and Scott, R. W.: Use of Vitamin B12 in the Management of the Neurologic Manifestations of Diabetes Mellitus, with Notes on the Administration of Massive Doses , Ann. Int. Med. 35:1028-1048 ( (Nov.) ) 1951.Crossref

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1955

References