Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Markers for Edmonston Measles Virus

Markers for Edmonston Measles Virus Abstract Preceding reports at this conference have already considered many aspects of the question of markers for the measles virus. Table 1 recapitulates some of these markers that have already been discussed. Two more will have to be added in the light of the report by Dr. Buynak, Dr. Hilleman, and co-workers1 describing the plaques produced by the attenuated Edmonston strain in cultures of chick embryo and grivet kidney cells and the neuropathology produced by the virulent Edmonston strain after thalamic inoculation in the monkey. Virulent early kidney-cell-passage virus does not seem to grow in chick cells, where as the attenuated does. In one stable amnion cell line, developed at the Sterling-Winthrop Company laboratories, the 20th passage of the human kidney line induces few or no cytopathic effects. Virus from the 30th passage level in this medium does, however, cause extensive changes. The attenuated agent grows well in this line References 1. Buynak, E. B.; Peck, H. M.; Creamer, A. A.; Goldner, H., and Hilleman, M. R.: Differentiation of Virulent from Avirulent Measles Strains , Amer. J. Dis. Child. 103: this issue, page 460. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Loading next page...
 
/lp/american-medical-association/markers-for-edmonston-measles-virus-cS0hns0LOL
Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1962.02080020485066
Publisher site
See Article on Publisher Site

Abstract

Abstract Preceding reports at this conference have already considered many aspects of the question of markers for the measles virus. Table 1 recapitulates some of these markers that have already been discussed. Two more will have to be added in the light of the report by Dr. Buynak, Dr. Hilleman, and co-workers1 describing the plaques produced by the attenuated Edmonston strain in cultures of chick embryo and grivet kidney cells and the neuropathology produced by the virulent Edmonston strain after thalamic inoculation in the monkey. Virulent early kidney-cell-passage virus does not seem to grow in chick cells, where as the attenuated does. In one stable amnion cell line, developed at the Sterling-Winthrop Company laboratories, the 20th passage of the human kidney line induces few or no cytopathic effects. Virus from the 30th passage level in this medium does, however, cause extensive changes. The attenuated agent grows well in this line References 1. Buynak, E. B.; Peck, H. M.; Creamer, A. A.; Goldner, H., and Hilleman, M. R.: Differentiation of Virulent from Avirulent Measles Strains , Amer. J. Dis. Child. 103: this issue, page 460.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1962

References